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FDA Authorizes Phase 1 Trial of ImmunityBio’s Novel COVID-19 Vaccine Candidate hAd5; Dual Construct is Designed to Drive Both T Cell and Antibody Immunity

The Pharma Data

“While there are a number of vaccine candidates in development, we believe most are limited by their sole focus on antibody responses to the monovalent spike protein, which may be insufficient to activate the full potential of the immune system to fight the coronavirus,” said Dr. Patrick Soon-Shiong, Chairman and CEO of ImmunityBio. “By

Vaccine 40
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Not all neoantigens are created equal

Drug Target Review

These neoantigens are identified by T cells of the immune system as foreign proteins and thus trigger an immune response. Recognition of bacteria, viruses and fungal invaders as ‘foreign’ makes sense, but how does the immune system recognise cancer cells as a threat?

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Codon Digest: Seeing Colors After Gene Therapy

Codon

a lower risk of immune responses. reports Cas9 proteins that can penetrate into the central nervous system without being packaged into an adeno-associated virus, all while causing a lower immune response than a prior version of the same technology. ” The tool was crafted with a virus, called GIL16.

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Codon Digest: Seeing Colors After Gene Therapy

Codon

a lower risk of immune responses. reports Cas9 proteins that can penetrate into the central nervous system without being packaged into an adeno-associated virus, all while causing a lower immune response than a prior version of the same technology. ” The tool was crafted with a virus, called GIL16.

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AvantGen Announces Licensing of Its Anti-SARS-CoV-2 Antibodies to IGM Biosciences for COVID-19 Therapy Development

The Pharma Data

Upon binding, the antibodies block the spike protein from interacting with ACE2 and thereby prevent virus-induced cell-killing, also known as cytopathic effect. Since 2010, IGM Biosciences has worked to overcome the manufacturing and protein engineering hurdles that have limited the therapeutic use of IgM antibodies.

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The Dangers of Mirrored Life

Codon

It would also be undetectable by key parts of the human immune system. Some scientists even think it had a virus defense system; “researchers say LUCA likely housed 19 CRISPR genes, which bacteria use to slice up viral threats,” reports Quanta Magazine. In 2010, researchers at the J. Not all pathogens spread quickly.

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The Quest for Universal Flu Vaccines

Codon

The influenza virus was not isolated until 1933, when an epidemic in London enabled British researchers Wilson Smith, Christopher Andrewes, and Patrick Laidlaw to collect human influenza virus from patients’ throat washings. The inoculated eggs were incubated, allowing the virus to multiply. Subscribe to Asimov Press!

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