How to Get Drugs Into the Brain
Drug Hunter
AUGUST 21, 2023
In 2010 , Pfizer developed a CNS-specific “MPO score” based on pK a , TPSA, and HBD count, but also lipophilicity measures of calculated partition coefficient (CLogP), calculated distribution coefficient (CLogD), and molecular weight (MW). A) Progression of a Novartis HAT program from a screening hit to brain-penetrant leads.
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