Drug Target Review
NOVEMBER 1, 2023
So that is a wide range of techniques to look at the protein-ligand interactions, all with the aim to guide the optimisation of our first screening hits to potent inhibitors that hopefully are cell-active at some point.
Drug Hunter
AUGUST 21, 2023
In 2010 , Pfizer developed a CNS-specific “MPO score” based on pK a , TPSA, and HBD count, but also lipophilicity measures of calculated partition coefficient (CLogP), calculated distribution coefficient (CLogD), and molecular weight (MW). A) Progression of a Novartis HAT program from a screening hit to brain-penetrant leads.
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