PLOS: DNA Science

MAY 25, 2023

Father and daughter died within weeks of each other in early 2010. Targeting Treatment Monoclonal antibody technology was born in the 1970s, and short interfering RNAs (siRNAs) described in 1999. The post Experimental Myotonic Dystrophy Treatment Teams Monoclonal Antibody and siRNA appeared first on DNA Science.

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Broad Institute

JANUARY 25, 2024

“This could potentially help with disease prevention — if we know from someone’s retinal image that they are at high risk of developing glaucoma or cardiovascular disease in the future, we could refer them for follow-up screening or preventative treatment.”

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New Drug Approvals

SEPTEMBER 6, 2024

US10071079, Example 15 Ref WO2018005586 [link] The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention that are useful for the treatment of conditions related to TLR modulation, such as inflammatory and autoimmune diseases, and methods of inhibiting the activity of TLRs in a mammal.

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Drug Target Review

JUNE 19, 2024

Our goal is to stand on the shoulders of giants and advance this exciting and new field of medicine, so that it can deliver valuable treatments to patients. How do you envision the future of cell therapy and its potential impact on medical treatments and healthcare? Could you give us an overview of the Lineage platform?

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Common Sense for Drug Policy Blog

AUGUST 26, 2024

dwf_admin Mon, 08/26/2024 - 12:56 Source Global status report on alcohol and health and treatment of substance use disorders. . "• Globally, an estimated 400 million people, or 7% of the world’s population aged 15 years and older, live with alcohol use disorders, and an estimated 209 million (3.7% Geneva: World Health Organization; 2024.

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The Pharma Data

JANUARY 12, 2021

12, 2021 — You have probably seen the social media posts: Your good friend’s co-worker is raising money online to help pay for cancer treatments or another friend needs funds to pay medical bills after a car crash. TUESDAY, Jan. Suveen Angraal, an internal medicine resident physician at the University of Missouri-Kansas City.

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Eye on FDA

JUNE 14, 2023

The latest letter was issued for a website that promoted a treatment for hypercortisolemia in patients with Cushings Disease. It was the second letter for this company, the first having been issued in August, 2020 for a TV advertisement. Of those without boxed warnings (9 in number), only 2 had Warning Letters.

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Drug Target Review

NOVEMBER 1, 2023

The mission of the CCDD is to discover novel small-molecule therapeutics for the treatment of cancer and progress them to hypothesis testing phase 1 clinical trials. I work in the Centre for Cancer Drug Discovery (CCDD) at The Institute of Cancer Research in London, which is an academic drug discovery centre.

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The Pharma Data

DECEMBER 2, 2020

At the 2016 UN High-level Meeting on ending AIDS, member states committed to a 75% reduction of TB deaths among people living with HIV by 2020, compared with 2010. TB preventive treatment (TPT) among people living with HIV has been shown to significantly reduce the risk of developing TB and dying from it. Source link.

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Conversations in Drug Development Trends

FEBRUARY 28, 2023

95% of rare diseases don’t have a treatment approved and won’t anytime soon. Back in 2010, Rob Long was a 22-year-old football player at Syracuse University on the path towards his dream career of becoming a punter in the NFL. Miraculously, there was an approved treatment. Uplifting Athletes (UA) is on a mission to change that.

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The Pharma Data

DECEMBER 30, 2020

30, 2020 — Women with advanced breast cancer who undergo surgery to remove the tumor after chemotherapy or another type of systemic treatment may live longer than those who don’t have surgery, a new study suggests. WEDNESDAY, Dec. The database also included information about their hormonal and HER2 cancer status.

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Drug Hunter

AUGUST 21, 2023

In 2010 , Pfizer developed a CNS-specific “MPO score” based on pK a , TPSA, and HBD count, but also lipophilicity measures of calculated partition coefficient (CLogP), calculated distribution coefficient (CLogD), and molecular weight (MW). 2010 , 1 (6), 435-449. ” ACS Chem. link] (Pfizer) Wager, T.T.; Verhoest, P.R.;

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The Pharma Data

JUNE 26, 2021

The FDA also approved Pradaxa oral pellets to prevent recurrent clots among patients 3 months to less than 12 years old who completed treatment for their first venous thromboembolism. Pradaxa was originally approved in 2010 to reduce the risk of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation.

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Drug Target Review

FEBRUARY 28, 2024

Over the past 25 years, T-cell therapies have gained significant ground in the treatment of cancer. Prior to that, Mr Ho was at New Leaf Venture Partners, a leading healthcare venture capital firm, where he launched and managed the public investments and cross-over portfolio, and served as its Public Investment Director from 2010 to 2014.

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FDA Law Blog: Biosimilars

JULY 11, 2023

As a result of the Biologics Price Competition and Innovation Act (BPCIA) passed in 2010, the definition of a “biological product” expanded to include “proteins.” To set the stage for this case, we need to go back to March 2020 , when a new definition of “biological product” threw the world of protein products into a tizzy.

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Drug Target Review

APRIL 23, 2024

As a result, drug developers can expedite the path to clinical and commercial stages, meaning patients will receive essential treatments at accelerated rates. Rob joined Cresset as CEO in 2010 and now also serves as Chairman of Cresset. Having this insight before ‘wet lab’ testing can help introduce significant time and cost savings.

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Agency IQ

OCTOBER 20, 2023

FDA’s newest draft guidance lays out considerations for developing treatments for diabetic foot infections In a new draft guidance document released within weeks of a related clinical practice guideline, the FDA provides considerations for developing therapies to treat diabetic foot infections, focusing on Phase 3 efficacy trials.

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The Pharma Data

APRIL 27, 2021

Roche announces five new intended uses for key cardiac biomarkers to help identify cardiovascular risk, better diagnose patients and support early treatment. Early diagnosis and treatment can contribute to saving or improving people’s lives and could help healthcare systems save money.

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The Pharma Data

OCTOBER 14, 2020

Food and Drug Administration (FDA) has approved WAKIX® (pitolisant) for the treatment of cataplexy in adult patients with narcolepsy. WAKIX is the first and only treatment approved by the FDA for people with excessive daytime sleepiness or cataplexy associated with narcolepsy that is not scheduled as a controlled substance by the U.S.

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The Pharma Data

NOVEMBER 27, 2020

Moreover, opioid overdose deaths involving stimulants increased 351% between 2010 and 2018. They also found that stimulants such as cocaine and crystal methamphetamine are the non-opioid substances most commonly involved in opioid overdose deaths in young people. Hadland is a pediatrician and addiction specialist at the hospital.

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Common Sense for Drug Policy Blog

JULY 8, 2023

It has been criticized, for example, on the ground that there is a contradiction between the ideas of consent to treatment and the obligation to go to Commissions which, in turn, can apply sanctions (to people who do not have a substance use disorder) [ 6 ].

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Drug Target Review

FEBRUARY 26, 2024

Rather than solely identifying tumour-associated mutations which can be specifically targeted for effective treatment, we now need to consider how non-mutational events play into both the development of the primary tumour and the development of therapy resistance.

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Common Sense for Drug Policy Blog

DECEMBER 20, 2023

DCRs are intended to complement existing prevention, harm reduction and treatment interventions, and are known by various names (see Box 1). Importantly, they aim to offer hygienic conditions, often supervision by medically trained staff, and a safe environment where people can use drugs without fear of arrest or legal repercussions.

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Codon

JANUARY 21, 2024

yellow fever, malaria, and dengue), evaluating new drugs or treatments, and studying pathogenesis, the process by which a disease develops. Scientists studied black men infected with syphilis for several decades while withholding known treatments. You can do a challenge trial with deadly diseases, but you need a “rescue therapy.”

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The Pharma Data

MARCH 16, 2021

By combining our expertise, we hope to make significant steps forward to finding solutions for patients for which there currently is no treatment.”. Hugh Marston, Ph.D., Head of Department CNS Diseases Research at Boehringer Ingelheim. “By The Lieber Institute for Brain Development.

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Codon

APRIL 9, 2024

In response to the precipitous rise in incidence, governments on both sides of the Pacific began a systematized search for antimalarial treatments. Over the course of 12 years, the Walter Reed Army Institute of Research (WRAIR) screened more than 250,000 compounds in search of an efficacious treatment. Nobody had an answer.

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Drug Target Review

AUGUST 9, 2024

Inhalers are useful in respiratory conditions, whereas topical treatments can be applied directly to the skin for localised treatment. Developing the correct formulation for these treatments will be key to ensure they are effective. For other compounds, it can be beneficial to target the drug more precisely to the affected area.

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The Pharma Data

DECEMBER 20, 2020

Interventional treatment for mitral regurgitation is considered to be one of the most challenging areas in the field of structural heart disease, yet also represents huge market potential. “We remain committed to bringing the best treatment option for the broadest patient population to market. About HighLife.

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The Pharma Data

MARCH 5, 2021

Food and Drug Administration (FDA) approved Actemra ® /RoActemra ® (tocilizumab) subcutaneous injection for slowing the rate of decline in pulmonary function in adult patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD), a debilitating condition with limited treatment options. 1-3 SSc affects about 2.5

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The Pharma Data

JUNE 18, 2021

. “We are encouraged by these promising results, which indicate ibrutinib and venetoclax combined has the potential to serve as an important chemotherapy-free, fixed-duration treatment option for people living with CLL,” said Dr. Paolo Ghia , M.D., 95% irrespective of subsequent randomized treatment ( Wierda, ASH 2020 ).

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Drug Target Review

MAY 11, 2023

In 2010, Professor Wolf-Dietrich Heyer and Kowalczykowski’s research teams at UC Davis were able to isolate and purify the BRCA2 protein and demonstrate its critical role in DNA repair. Secondly, several cancer treatment drugs work by inducing DNA damage.

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The Pharma Data

JULY 15, 2021

Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time. UK Biobank recruited 500,000 people aged between 40-69 years in 2006-2010 from across the UK.

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The Pharma Data

OCTOBER 25, 2020

GMA 301 is the first antibody drug for PAH treatment. About Gmax Biopharm LLC: Gmax is a clinical stage company established in 2010 and headquartered in Hangzhou, China. HANGZHOU, China , Oct. In the phase 1A trial, it demonstrated superior safety profile in a single dose of 75, 200, 500, and 1000 mg, with a half-life of 500-570 hours.

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The Pharma Data

APRIL 4, 2023

1*† CoolMonth activities encourage people who are considering a non-invasive body contouring treatment to have a conversation with a trusted healthcare provider and an open dialogue about what is realistic for their body contouring goals. In addition, 92% of people would like help getting their body ready for summer.

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The Pharma Data

MARCH 29, 2022

Global Head of Research and Development, Sanofi “We look forward to this collaboration with IGM Biosciences, a pioneer in a new class of antibody medicines for the treatment of cancer, immunology , and inflammatory diseases. John Reed, M.D., About IGM Biosciences, Inc. Source link: [link].

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The Pharma Data

MARCH 30, 2021

PPH is one of the most common complications of birth, resulting in pharmacologic treatment in up to 10% of mothers and potentially resulting in emergency intervention such as hysterectomy and blood transfusions, and, in some cases, maternal death. Alydia Health was represented by Guggenheim Securities as financial advisor. and globally.

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The Pharma Data

JANUARY 12, 2021

From 2010 to 2020, Dr Graham was VP of Strategic Program Direction, Immunology and Inflammation at Regeneron Pharmaceuticals, Inc., The company is accelerating development of anti-Interleukin 6 receptor (IL6R) mAb, a fully human monoclonal antibody for treatment of IL6-induced inflammation, especially for treatment of COVID-19 patients.

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