Drugs.com

FEBRUARY 14, 2025

million, between 2011 and 2022, a. FRIDAY, Feb. 14, 2025 A growing numbers of family members now provide care for older adults who live at home or in residential care settings, a new study shows.Their ranks increased 32%, from 18.2 million to 24.1

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Drugs.com

JULY 18, 2024

THURSDAY, July 18, 2024 -- Alix Popham played in two rugby World Cups and won a Six Nations Grand Slam before retiring in 2011 as a professional in the rough-and-tumble game. By 2020, he had already been diagnosed with early onset dementia and.

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Broad Institute

JANUARY 14, 2025

When I received my genetic test report in 2011, the world had never heard of base editing. The findings appear in Nature Medicine. As a patient scientist, I think often about how lucky we are to be coming at this problem now, said Vallabh. Its a huge privilege to have the opportunity to point these powerful new tools at our disease.

Disease 144

Disease DNA Protein Production Treatment 144

Covalent Modifiers

FEBRUARY 6, 2024

However, there has been a resurgence in covalent drug design following the success of several covalent drugs such as boceprevir (2011), ibrutinib (2013), neratinib (2017), dacomitinib (2018), zanubrutinib (2019), and many others.

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Drugs Research 182

NIOSH Science Blog: Drugs

APRIL 10, 2024

From 2011 to 2022, there were 1,462 fatal occupational injuries that occurred at road construction sites.[1] Struck-by injuries are the leading cause of nonfatal injuries and second most common cause of fatalities among construction workers.

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International 113

SCIENMAG: Medicine & Health

OCTOBER 31, 2023

AMES, Iowa – Since 2011, roughly 10,000 people in the U.S. Credit: Photo by Ryan Riley/Iowa State University AMES, Iowa – Since 2011, roughly […] have turned 65 every day. The Baby Boomer generation and those born before 1946 make up the country’s fastest growing age group, which is on track to outnumber children by 2035.

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Antidote

JANUARY 29, 2024

Jamie received a diagnosis of stage IV melanoma in 2011, only 11 weeks after giving birth to her child. Not only will patients be able to gain access to potential new treatments, but they will also be directly contributing to research that can save lives — something that Jamie Troil Goldfarb has experienced firsthand.

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Clinical Trials Trials Doctors Treatment 122

Drug Patent Watch

DECEMBER 30, 2024

Pharmaceutical Regulations in Japan 2020. Retrieved from [link] Pharmaceuticals and Medical Devices Agency. Regulatory System on Generic Drugs in Japan. Retrieved from [link] Raflzadeh-Kabe, J. Japanese Pharmaceutical and Regulatory Environment. Journal of Clinical Pharmacology , 51(3), 531538.

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Drug Development Clinical Pharmacology Clinical Trials Pharmaceutical Companies 52

FDA Law Blog: Biosimilars

NOVEMBER 14, 2024

However, it’s fair to say that FDA’s food program has focused primarily on implementation of the many mandates in the Food Safety Modernization Act of 2011. More recently, the agency invested significant efforts in modernizing nutrition labeling requirements and implementing a sodium reduction initiative.

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FDA Disease Regulations Production 64

SCIENMAG: Medicine & Health

JANUARY 24, 2024

The Fukushima Daiichi nuclear disaster, triggered by the earthquake and tsunami on March 11, 2011, resulted in a severe release of radioactive materials, including cesium, from the damaged nuclear reactors.

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SCIENMAG: Medicine & Health

MARCH 22, 2024

There were multiple unsafe sleep practices at play in more than three-quarters of Sudden Unexpected Infant Deaths reported in 23 jurisdictions between 2011 and 2020, a new study reveals. The researchers say the findings underscore the need for more comprehensive safe-sleep education for new parents, including from healthcare providers.

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Research 72

SCIENMAG: Medicine & Health

JULY 5, 2023

But a study published by The BMJ today finds that less than half of approved first indications for new drugs in the US and Europe between 2011 and 2020 add substantial therapeutic value over existing treatments […]

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Treatment Drugs Disease 67

Sygnature Discovery

FEBRUARY 12, 2025

Since 2011, Sygnature Discovery has delivered 50 novel pre-clinical and 30 clinical compounds, with its scientists named on over 170 patents. Additional sites are located in Alderley Park, Macclesfield, and Glasgow (UK), as well as Montreal and Quebec City (Canada).

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Disease Science Marketing Drugs 52

PLOS: DNA Science

MARCH 21, 2024

A Long and Winding Diagnostic Road The story begins in 2011, with Alessandra Biffi, MD, head of the clinical trial for MLD at the San Raffaele Telethon Institute for Gene Therapy in Milan. The boy was accepted into the clinical trial in Italy and received the gene therapy in 2011, but it was too late for Liviana.

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Therapies Clinical Trials DNA Trials 98

Agency IQ

APRIL 12, 2024

BY RACHEL COE, MSC Late last year, the FDA published a draft update to its 2011 guidance on potency assays for cell and gene therapy products, unveiling a major shift in approach to the issue. Now, the deadline for feedback to that draft guidance has passed, and AgencyIQ has an analysis of the comments here.

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Production Laboratories FDA Regulations 59

Perficient: Drug Development

AUGUST 31, 2023

Kotlin is a programming language introduced by JetBrains in 2011. Our Kotlin tutorial includes. What is Kotlin? Pre-Requisites Features of Kotlin Kotlin Architecture What is Kotlin? Kotlin is free, has been free and will remain free. It is developed under the Apache 2.0 Google announced Kotlin is an official language for android development.

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Licensing Licensing International 105

The Pharma Data

DECEMBER 7, 2020

older adults who reported owning and using hearing aids increased from 2011 to 2018, according to a research letter published online Dec. percent in 2011, 2015, and 2018, respectively. MONDAY, Dec. 7, 2020 — The proportion of U.S. 7 in JAMA Internal Medicine. Nicholas S. Reed, Au.D., percent).

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International Research 52

Common Sense for Drug Policy Blog

DECEMBER 12, 2023

Total Adult Community Supervision Population in the US "From yearend 2011 to yearend 2021, the total adult community supervision population fell 22%, from 4,818,300 to 3,745,000 (table 1). Between 2011 and 2019, the U.S. Most of this decrease was due to a decline of 25% (1 million) in the number of adults on probation.

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Broad Institute

MARCH 8, 2024

Hung (2010 - 2011 awardee) James Bradner Jake Jaffe 2011 - 2012 Awardees Feng Zhang John Rinn Mitchell Guttman Anne Carpenter 2010 - 2011 Awardees Deborah T. Any questions about the Next Generation Awards program can be directed to Jacob Herman at jherman@broadinstitute.org. Hung Bradley Bernstein Tarjei Mikkelsen

Research 52

Research 52

National Drug & Alcohol Research Centre Blog

FEBRUARY 12, 2024

The study, published in Drug and Alcohol Review, examined deaths from acute alcohol poisoning in Australia, 2011–2022. A new study led by researchers at the National Drug and Alcohol Research Centre (NDARC), UNSW Sydney, has explored the circumstances of death and characteristics of fatal alcohol poisoning cases.

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Disease Treatment Drugs Research 110

SCIENMAG: Medicine & Health

OCTOBER 11, 2023

However, the Great Atlantic Sargassum Belt (GASB) that emerged in 2011 has since then caused unprecedented inundations of this brown seaweed on Caribbean coastlines, with harmful effects on ecosystems while posing challenges […] 11, 2023) — Under normal conditions, the floating macroalgae Sargassum spp.

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SCIENMAG: Medicine & Health

SEPTEMBER 27, 2023

Credit: Copyright © 2011 Michael Bonert […] Over time, accumulating scarring distorts the liver, interferes with its blood supply and may progressively lead to worsening consequences, from cirrhosis to liver failure to liver cancer. In advanced cases, the only treatment is an organ transplant.

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Treatment 52

FDA Law Blog: Biosimilars

AUGUST 12, 2024

Patent and Trademark Office consulted with FDA on the appropriate timelines, FDA claimed that the INAD, and thereby the testing phase, was not effective until August 4, 2011 because no NCIE was submitted until then. Thus, the Agency concluded, the June 2011 date should stand. On August 8, 2024, the Court granted Nissan et al.’s

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FDA Regulations FDA Approval Drugs 59

Broad Institute

MARCH 14, 2024

In the new study, the researchers used a system called phage-assisted continuous evolution (PACE), first developed in Liu’s lab at Harvard in 2011, to generate a degron that might work with PT-179. PACE allows researchers to rapidly evolve new proteins that have useful features.

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Targeted Protein Degradation Small Molecule Medical Schools Science 141

New Drug Approvals

NOVEMBER 13, 2023

amcrasto@amcrasto /////////// Ref [1]. amcrasto@amcrasto /////////// Ref [1].

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Treatment Disease Therapies Production 62

Drug Target Review

FEBRUARY 12, 2024

In 2007, I was involved in a ‘management buy-in’, before selling the company to Ipca Laboratories in 2011. I became a Director in 2005, responsible for the business’s continued growth from 7 initial founding members to 110 employees today.

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International Science Laboratories Pharmaceuticals 111

New Drug Approvals

SEPTEMBER 8, 2024

September 2011). “MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin” The Journal of Clinical Endocrinology and Metabolism. . ^ Bays HE, Schwartz S, Littlejohn T, Kerzner B, Krauss RM, Karpf DB, et al.

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FDA Licensing Licensing FDA Approval 62

Common Sense for Drug Policy Blog

JANUARY 5, 2024

This estimate is more than 5 times the most recent US estimate of ∼774,000 from 2011 [ 25 ]. Much of this increase is likely attributable to increases in IDU, but it is important to consider methodological differences in the creation of this 2018 estimate vs the 2011 estimate. during the past decade.

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Drugs Treatment Disease Therapies 40

Drug Target Review

NOVEMBER 1, 2023

2011 Jul 14;54(13):4619–26. Molecular Neurobiology. 2020 Jan 1;57(1):372–92. Albers HMHG, Hendrickx LJD, van Tol RJP, et al. Structure-Based Design of Novel Boronic Acid-Based Inhibitors of Autotaxin. Journal of Medicinal Chemistry. Keune WJ, Potjewyd F, Heidebrecht T, et al. J Med Chem. 2017 Mar 9;60(5):2006–17.

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Clinical Trials Trials Small Molecule Disease 134

FDA Law Blog: Biosimilars

MAY 27, 2024

Jennifer was with the firm from 2011-2017, before leaving for in-house roles at Apple, Abbott Laboratories, and Cognito Therapeutics. “Jennifer’s return adds depth and breadth to our device practice and her strong relationships from her earlier time at the firm has made for a seamless reentry,” said J.P. Ellison, Managing Director at HPM.

Laboratories 59

Laboratories Compliance FDA Regulations 59

Drug Target Review

NOVEMBER 9, 2023

Physiological Reviews [Internet] 2011 April 1 [2023 November 9]; 91(2):555-602. This could be leveraged to find new therapeutic approaches for neurodegenerative diseases.” This study was published in Molecular & Cellular Proteomics. References 1 Alcaraz G, Campanac E, Carlier E, et al. Axon Physiology. Available from: [link]

RNA 98

RNA Disease Science Research 98

Broad Institute

AUGUST 31, 2023

To optimize the reverse transcriptase domain of prime editors in a more directed way, Liu’s group turned to PACE (phage-assisted continuous evolution), a directed evolution approach developed by Liu in 2011. Only those expressing gene variants with specified desirable traits can survive by replicating faster than they are diluted.

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DNA RNA Engineering Laboratories 145

Drug Target Review

DECEMBER 1, 2023

2011 February 1 [2023 November 15]; 20(1):5-14. He concluded: “This breakthrough, driven by our commitment to advancing scientific frontiers, heralds a milestone in the realm of cellular studies.” This study was published in Lab on a Chip. Reference 1 Ding DC, Lin SZ, Shyu WC. Mesenchymal Stem Cells. Cell Transplantation.

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Therapies Engineering Treatment Disease 105

Common Sense for Drug Policy Blog

OCTOBER 21, 2024

2008 ; Torruella, 2011 ). Although human intoxication with xylazine has been reported sporadically over the past several decades in a number of case studies ( Ruiz-Colón et al., 2014 ; Forrester, 2016 ), it was first described as a more prevalent additive in the unregulated drug supply of Puerto Rico ( Reyes et al., 2012 ; Rodríguez et al.,

Drugs 52

Drugs 52

Drug Target Review

JULY 24, 2023

Between May 2011 and March 2016, he was Professor, Chemical Resources Laboratory at the Tokyo Institute of Technology. Meanwhile, the relationship of apicoplast to the parasite’s intrinsic oscillation has not been known, therefore, the present finding may provide novel drug targets disturbing the apicoplast-related intracellular signalling.

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RNA Regulations Bioinformatics Laboratories 98

The Pharma Data

NOVEMBER 17, 2020

31, 2011, to examine the impact of antibiotic exposure in the first two years of life. Zaira Aversa, M.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues conducted a population-based cohort study involving children born in Olmsted County, Minnesota, between Jan. 1, 2003, and Dec.

Therapies 52

Therapies Doctors Disease Research 52

The Pharma Data

OCTOBER 21, 2020

Melike Yildirim, from the Georgia Institute of Technology in Atlanta, and colleagues used patient data from Medicaid Analytic eXtract files to identify patients with persistent asthma in 2010 and 2011 from New York and Michigan.

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Vaccine Government Research 52