Drug Target Review

NOVEMBER 1, 2023

We often screen using a biochemical assay, but we can conduct cell-based screening as well. For fragment screening, we can screen with biophysical methods, such as thermal shift assays or, you may have heard about Surface Plasmon Resonance (SPR) which is a very sensitive biophysical technique used for fragment screening.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

Agency IQ

APRIL 12, 2024

Draft guidance on potency assays for CGT products garners extensive stakeholder input Late last year, the FDA published a draft update to its 2011 guidance on potency assays for cell and gene therapy products, unveiling a major shift in approach to the issue.

Production 40

Production FDA Therapies Biochemical Assays 40

Drug Discovery World

OCTOBER 14, 2022

Wagner, MALDI imaging mass spectrometry: Bridging biology and chemistry in drug development, Bioanalysis, 2011, 3: 2427–2441, [link]. Trapped ion mobility spectrometry: Improving the specificity of MALDI-MS-based HTS . Castellino, M.R. Groseclose and D. Ritorto, R. Perez-Oliva, A. Knebel, S.J. Buhrlage, M. Wightman, S.M. Kelly, N.T.

Synthetic Chemistry 130

Synthetic Chemistry Cell Based Assays Biochemical Assays Analytical Chemistry 130