Drug Target Review

NOVEMBER 1, 2023

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. The Journal of Cell Biology. 2011 Jul 14;54(13):4619–26. Umezu-Goto M, Kishi Y, Taira A, et al. 2002 Jul 22;158(2):227–33. Valdés-Rives SA, González-Arenas A. Mediators of Inflammation. 2017;2017:1–15.

Clinical Trials 134

Clinical Trials Trials Small Molecule Disease 134

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. When I began my PhD I completely switched my focus, and I haven’t looked back,” said Manguso.

Research 137

Research Immune Response Clinical Trials Therapies 137

NIH Director's Blog: Drug Development

SEPTEMBER 20, 2018

While researchers had solved the structure of a GPCR bound to another class of G proteins, known as stimulatory G proteins (G s ) in 2011[3], the image you see above represents the first such glimpse of a GPCR bound to any G i protein. 2011 Jul 19;477(7366):549-55.

Laboratories 52

Laboratories Research Drugs Regulations 52

Codon

OCTOBER 22, 2024

Another example of an erroneous “big idea” concerns data reported in 2011 by researchers at CERN, purporting to show neutrinos (a kind of subatomic particle) traveling faster than light. Enormous amounts of resources were wasted chasing LK-99 that could have been saved by heeding a council of experts.

Science 108

Science Research Government Cell Biology 108

New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

Production 62

Production DNA RNA Regulations 62

Codon

APRIL 9, 2024

When Louis Miller, now Chief of Malaria Cell Biology at the NIH, attended a malaria conference in Shanghai in 2008, he asked: Who discovered artemisinin? Miller and Su published an article on Tu’s story in Cell in 2011. Nobody had an answer.

Drugs 137

Drugs Science Research Doctors 137

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). Nature (2011).

DNA 97

DNA Cell Biology Molecular Biology Engineering 97