Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. When I began my PhD I completely switched my focus, and I haven’t looked back,” said Manguso.

Research 137

Research Immune Response Clinical Trials Therapies 137

Codon

APRIL 9, 2024

Department of Defense administered mefloquine, the synthetic drug developed at Walter Reed in the U.S., only issued “the strongest ‘black box’ warning” against the drug in 2013. Miller and Su published an article on Tu’s story in Cell in 2011. Nobody had an answer.

Drugs 129

Drugs Science Research Doctors 129

NIH Director's Blog: Drug Development

SEPTEMBER 20, 2018

While researchers had solved the structure of a GPCR bound to another class of G proteins, known as stimulatory G proteins (G s ) in 2011[3], the image you see above represents the first such glimpse of a GPCR bound to any G i protein. 2011 Jul 19;477(7366):549-55.

Laboratories 52

Laboratories Research Regulations Drugs 52

New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

Production 62

Production DNA RNA Regulations 62