Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Most medicines, including insulin and semaglutide (the weight loss drug), are made using DNA cloning. However, E.

DNA 79

DNA RNA Laboratories Research 79

Codon

AUGUST 26, 2024

In 2011, research groups at the MIT Lincoln Laboratory and Boston University fused together two different proteins to make broad antivirals: one protein binds to double-stranded RNA, and the other triggers apoptosis, or cell death. In fact, the innate immune system uses double-stranded RNA as a key signal that an infection is underway.

RNA 99

RNA Virus DNA Vaccine 99

Drug Target Review

DECEMBER 7, 2023

In an infected animal, cGAS senses viral DNA in cytoplasm whilst in an uninfected organism, DNA is confined in the nucleus. Bacteria must take a different approach as they do not have nuclei and if CBASS reacted to the presence of DNA, it would cause autoimmunity or the bacterium to attack itself, Banh said. Phages in nature.

RNA 59

RNA Immune Response DNA Molecular Biology 59

Broad Institute

AUGUST 25, 2023

Together, our researchers and collaborators have harnessed and advanced DNA mapping and sequencing technologies, and have assembled the world’s largest collection of DNA samples in psychiatric research — including samples for schizophrenia, bipolar disorder, other psychiatric disorders, and healthy control samples.

Research 52

Research DNA International Disease 52

Drug Target Review

JULY 24, 2023

In addition, we have concluded that the gene product is an apicpolast RNA polymerase sigma factor because of the localisation of the gene product, ApSIGMA, in the apicoplast interaction with apicoplast promoter DNA sequences, and the activity of an ApSIGMA- E.coli _RpoS chimeric sigma factor protein.

RNA 98

RNA Regulations Bioinformatics Laboratories 98

Drug Target Review

JULY 5, 2023

After binding, the transposase enzyme will excise the flanked section of DNA (termed the transposon) and insert it into sites in the genome at specific target sequences. An example of the former includes a report in the journal Nature of a new tool that can increase the amount of DNA that can be inserted using CRISPR-Cas9 technology.

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Engineering DNA Laboratories Production 105

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer.

Research 137

Research Immune Response Clinical Trials Therapies 137

BMG Labtech

OCTOBER 4, 2023

These numbers reflect impressive developments in DNA sequencing technologies but in most cases represent the immediate costs of consumables on the sequencing instrument. 2 DNA sequencing is also reliant on sample processing and DNA library preparation before sequencing as well as bioinformatics and data analysis after sequencing.

DNA 52

DNA RNA Bioinformatics Research 52

Codon

MAY 22, 2023

And experiments at Tune Therapeutics showed that CRISPR epigenome editing — which doesn’t cut DNA at all, but merely silences genes by adding chemical groups to them — can curb “bad cholesterol” by more than 50% in monkeys. These tools do not cut or nick DNA, and so they may be safer than other options.

DNA 57

DNA Engineering Science Trials 57

Codon

MAY 22, 2023

And experiments at Tune Therapeutics showed that CRISPR epigenome editing — which doesn’t cut DNA at all, but merely silences genes by adding chemical groups to them — can curb “bad cholesterol” by more than 50% in monkeys. These tools do not cut or nick DNA, and so they may be safer than other options.

DNA 52

DNA Engineering Science Trials 52

PLOS: DNA Science

SEPTEMBER 21, 2023

I attended the first meeting of H3Africa/ (Human Heredity and Health in Africa) in 2011, in Cape Town. What steps should researchers take when attempting to acquire DNA samples from modern descendants? The post The Festival of Genomics and Biodata 2023 Comes to Boston appeared first on DNA Science. From people who have died?”

DNA 52

DNA Science Medical Schools Government 52

The Pharma Data

FEBRUARY 22, 2022

After ten years at Sony France as Chief Financial Officer (2000-2002), and then General Secretary, she was appointed Chief Financial Officer of Europacorp Group in 2011. She began her career in 1992 at PricewaterhouseCoopers where she worked as an auditor and then a financial advisor.

Clinical Trials 52

Clinical Trials DNA Science Clinical Development 52

Codon

MARCH 19, 2024

Most cells (excluding T-cells and B cells after V(D)J recombination) in our body contain the same DNA but appear and behave in distinct ways: A neuron looks and acts very differently from a hepatocyte. While DNA is relatively stable , the epigenome is not; it has to orchestrate changes in cell state, cell type, and more.

DNA 57

DNA Small Molecule Regulations Laboratories 57

Codon

SEPTEMBER 19, 2024

In 1998, a Japanese group discovered the causative genes by using transposons, or small DNA sequences that insert themselves into genes, to randomly disrupt genetic functions inside cyanobacteria cells. In 2011, Chinese researchers found that cyanobacteria growing at 30°C quickly die off if they are dipped in 5°C water.

Laboratories 103

Laboratories Research DNA Science 103

Drug Target Review

JUNE 19, 2024

The other powerful benefit is that our cell lines can become any of the cell types of the human body – these cells have within their DNA the capability to become any of the more than 200 human cell types which you might want to manufacture. This provides some regulatory advantages, and of course, significant cost advantages.

Therapies 84

Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

The Pharma Data

JANUARY 24, 2021

Pamer joined the University of Chicago from Memorial Sloan Kettering Cancer Center in New York City, where he served as head of the Division of Subspecialty Medicine from 2011 to 2018 and director of the Center for Microbes, Inflammation and Cancer from 2010 to 2019.

Research 40

Research Bioinformatics Laboratories International 40

LifeSciVC

JULY 1, 2024

The central dogma of molecular biology is that information generally (with few exceptions) flows from DNA to RNA to Protein. In my own career, starting to write a blog was one of my most impactful “Friday afternoon experiments” – I even called it an experiment in my very first blogpost back in March 2011. Remember life’s Central Dogma.

Science 86

Science Immune Response Molecular Biology RNA 86

Agency IQ

APRIL 12, 2024

Draft guidance on potency assays for CGT products garners extensive stakeholder input Late last year, the FDA published a draft update to its 2011 guidance on potency assays for cell and gene therapy products, unveiling a major shift in approach to the issue. As a result, the 2011 guidance was generally seen as basic and outdated.

Production 40

Production FDA Therapies Biochemical Assays 40

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

The Pharma Data

DECEMBER 21, 2020

2011:29;2121-27. With seven new medicines launched between 2014 and 2020, and a broad pipeline of small molecules and biologics in development, the Company is committed to advance oncology as a key growth driver for AstraZeneca focused on lung, ovarian, breast and blood cancers. J Clin Oncol. Ellison G, et al. J Clin Pathol. 2013:66;79-89.

Treatment 52

Treatment Trials Disease FDA 52

New Drug Approvals

JANUARY 9, 2024

CDK7 also plays a role in transcription and possibly in DNA repair. The trimeric Cak complex CDK7/CyclinH/MATl is also a component of TFIIH, the general transcription/DNA repair factor IIH (Morgan, DO., Genes Dev.Oct 15;25(20):2158-72, 2011). 13, 261-91, 1997). Oct 1 5;24(20):2303-16, 2010; Blazek et al., Konig et al.,

Production 62

Production DNA RNA Regulations 62

Codon

OCTOBER 6, 2024

By combining mammoth DNA recovered from ancient permafrost with stem cells of the species’ closest living ancestor, the Asian elephant, the company aims to make hybrid embryos. 4 In 2011 a group of Russian and Japanese scientists claimed a woolly mammoth would be born within five years.

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FDA Hospitals Engineering Research 113

PLOS: DNA Science

MAY 2, 2024

Will an effort to determine the sex chromosome constitutions of nearly 600,000 men whose DNA is being analyzed in the Million Veteran Program provide helpful health information – or highlight another possible source of genetic judgment? It launched in 2011. appeared first on DNA Science.

DNA 52

DNA Engineering Disease Hospitals 52

Agency IQ

MARCH 29, 2024

Similarly, the Group I and II Polymers and Resins NESHAP were most recently updated when the agency conducted its RTR on December 16, 2008, and April 21, 2011. The HON standards were most recently updated when the agency conducted a residual risk and technology review (RTR) on December 21, 2006.

Regulations 40

Regulations Compliance Production Government 40

Sygnature Discovery

JANUARY 23, 2025

Additionally, he provided leadership on the successful technology transfer and implementation of DNA-encoded library screening at AstraZeneca, while playing a key role in building a targeted degradation platform. He has led teams in expressing and purifying protein targets for use in hundreds of drug discovery projects.

Science 52

Science DNA Disease International 52

Codon

MARCH 16, 2025

Today, decades after the invention of DNA sequencing, it is easy to take the accessibility of genomic data for granted. But in the early 1990s, when Guilford’s group began collecting blood and tumor samples from the MacLeods, DNA sequencing technology was still costly and unwieldy.

DNA 114

DNA Disease Medical Schools Hospitals 114

Codon

AUGUST 10, 2023

Nature (2011). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link Recent advances in DNA assembly technologies , by Chao R.

DNA 97

DNA Cell Biology Molecular Biology Engineering 97

Codon

AUGUST 10, 2023

Nature (2011). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link Recent advances in DNA assembly technologies , by Chao R.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Drug & Device Law

DECEMBER 19, 2022

604, 620 (2011) (“The question for ‘impossibility’ is whether the private party could independently do under federal law what state law requires of it.”). See PLIVA, Inc. Mensing , 564 U.S. 2) These changes include, but are not limited to: * * * *.

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FDA Regulations Production Drugs 59