The Pharma Data

JANUARY 24, 2021

Pamer joined the University of Chicago from Memorial Sloan Kettering Cancer Center in New York City, where he served as head of the Division of Subspecialty Medicine from 2011 to 2018 and director of the Center for Microbes, Inflammation and Cancer from 2010 to 2019.

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Research Bioinformatics Laboratories International 40

LifeSciVC

JULY 1, 2024

The central dogma of molecular biology is that information generally (with few exceptions) flows from DNA to RNA to Protein. In my own career, starting to write a blog was one of my most impactful “Friday afternoon experiments” – I even called it an experiment in my very first blogpost back in March 2011. Remember life’s Central Dogma.

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Science Immune Response Molecular Biology RNA 86

Agency IQ

APRIL 12, 2024

Draft guidance on potency assays for CGT products garners extensive stakeholder input Late last year, the FDA published a draft update to its 2011 guidance on potency assays for cell and gene therapy products, unveiling a major shift in approach to the issue. As a result, the 2011 guidance was generally seen as basic and outdated.

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Production FDA Therapies Biochemical Assays 40

Broad Institute

JANUARY 14, 2025

The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60 percent. When I received my genetic test report in 2011, the world had never heard of base editing. The findings appear in Nature Medicine.

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Disease DNA Protein Production Treatment 144

New Drug Approvals

JANUARY 9, 2024

CDK7 also plays a role in transcription and possibly in DNA repair. The trimeric Cak complex CDK7/CyclinH/MATl is also a component of TFIIH, the general transcription/DNA repair factor IIH (Morgan, DO., Genes Dev.Oct 15;25(20):2158-72, 2011). 13, 261-91, 1997). Oct 1 5;24(20):2303-16, 2010; Blazek et al., Konig et al.,

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Production DNA RNA Regulations 62

Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Most medicines, including insulin and semaglutide (the weight loss drug), are made using DNA cloning. However, E.

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DNA RNA Laboratories Research 82

PLOS: DNA Science

JUNE 27, 2024

The animals also tolerated conditions aboard the International Space Station in 2011, and seemed to have survived a crash into the moon from a probe in 2019. After all, they can reproduce even under radiation levels 1,000 times that which would kill a human, possessing admirable DNA repair skills.

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DNA Vaccine Research International 98

Drug Target Review

SEPTEMBER 4, 2023

5 Cytology-based profiling can facilitate antibiotic discovery efforts and, these assays assess cell cycle progression, nuclear and mitochondrial DNA content, mitochondrial DNA replication, nuclear DNA damage, mitochondrial membrane potential, and lysosome structure and function. link] Ojewale Kayode (2018). and Margaret, A.

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Drugs RNA DNA Disease 111

PLOS: DNA Science

MARCH 21, 2024

The history of gene therapy for MLD is compelling – DNA Science covered it for Rare Disease Day in 2021, here. A Long and Winding Diagnostic Road The story begins in 2011, with Alessandra Biffi, MD, head of the clinical trial for MLD at the San Raffaele Telethon Institute for Gene Therapy in Milan. She passed away in 2013.

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Therapies Clinical Trials DNA Trials 97

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer.

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Research Immune Response Clinical Trials Therapies 137

Drug Target Review

JULY 24, 2023

In addition, we have concluded that the gene product is an apicpolast RNA polymerase sigma factor because of the localisation of the gene product, ApSIGMA, in the apicoplast interaction with apicoplast promoter DNA sequences, and the activity of an ApSIGMA- E.coli _RpoS chimeric sigma factor protein.

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RNA Regulations Bioinformatics Laboratories 98

PLOS: DNA Science

SEPTEMBER 21, 2023

I attended the first meeting of H3Africa/ (Human Heredity and Health in Africa) in 2011, in Cape Town. What steps should researchers take when attempting to acquire DNA samples from modern descendants? The post The Festival of Genomics and Biodata 2023 Comes to Boston appeared first on DNA Science. From people who have died?”

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DNA Science Medical Schools Government 52

Codon

SEPTEMBER 19, 2024

In 1998, a Japanese group discovered the causative genes by using transposons, or small DNA sequences that insert themselves into genes, to randomly disrupt genetic functions inside cyanobacteria cells. In 2011, Chinese researchers found that cyanobacteria growing at 30°C quickly die off if they are dipped in 5°C water.

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Laboratories Research DNA Science 103

Codon

MARCH 19, 2024

Most cells (excluding T-cells and B cells after V(D)J recombination) in our body contain the same DNA but appear and behave in distinct ways: A neuron looks and acts very differently from a hepatocyte. While DNA is relatively stable , the epigenome is not; it has to orchestrate changes in cell state, cell type, and more.

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DNA Small Molecule Regulations Laboratories 56

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

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DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

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DNA Therapies Engineering Clinical Trials 52

PLOS: DNA Science

MAY 2, 2024

Will an effort to determine the sex chromosome constitutions of nearly 600,000 men whose DNA is being analyzed in the Million Veteran Program provide helpful health information – or highlight another possible source of genetic judgment? It launched in 2011. appeared first on DNA Science.

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DNA Engineering Disease Hospitals 52

The Pharma Data

FEBRUARY 22, 2022

After ten years at Sony France as Chief Financial Officer (2000-2002), and then General Secretary, she was appointed Chief Financial Officer of Europacorp Group in 2011. She began her career in 1992 at PricewaterhouseCoopers where she worked as an auditor and then a financial advisor.

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Clinical Trials DNA Science Clinical Development 52

Broad Institute

MAY 14, 2024

I've always been interested in solving problems,” Studier told Brookhaven National Laboratory in a 2011 profile. Studier realized that the protein, called the T7 RNA polymerase, might be able to quickly and efficiently produce RNA from not only T7 DNA, but also from the genes of any organism. My interest is in basic research."

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RNA Production Molecular Biology Laboratories 84

The Pharma Data

DECEMBER 21, 2020

2011:29;2121-27. With seven new medicines launched between 2014 and 2020, and a broad pipeline of small molecules and biologics in development, the Company is committed to advance oncology as a key growth driver for AstraZeneca focused on lung, ovarian, breast and blood cancers. J Clin Oncol. Ellison G, et al. J Clin Pathol. 2013:66;79-89.

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Treatment Trials Disease FDA 52

Codon

MAY 22, 2023

And experiments at Tune Therapeutics showed that CRISPR epigenome editing — which doesn’t cut DNA at all, but merely silences genes by adding chemical groups to them — can curb “bad cholesterol” by more than 50% in monkeys. These tools do not cut or nick DNA, and so they may be safer than other options.

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DNA Engineering Science Trials 58

Codon

MAY 22, 2023

And experiments at Tune Therapeutics showed that CRISPR epigenome editing — which doesn’t cut DNA at all, but merely silences genes by adding chemical groups to them — can curb “bad cholesterol” by more than 50% in monkeys. These tools do not cut or nick DNA, and so they may be safer than other options.

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DNA Engineering Science Trials 52

Codon

OCTOBER 6, 2024

By combining mammoth DNA recovered from ancient permafrost with stem cells of the species’ closest living ancestor, the Asian elephant, the company aims to make hybrid embryos. 4 In 2011 a group of Russian and Japanese scientists claimed a woolly mammoth would be born within five years.

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Codon

AUGUST 26, 2024

In 2011, research groups at the MIT Lincoln Laboratory and Boston University fused together two different proteins to make broad antivirals: one protein binds to double-stranded RNA, and the other triggers apoptosis, or cell death. In fact, the innate immune system uses double-stranded RNA as a key signal that an infection is underway.

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RNA Virus DNA Vaccine 99

Sygnature Discovery

JANUARY 23, 2025

Additionally, he provided leadership on the successful technology transfer and implementation of DNA-encoded library screening at AstraZeneca, while playing a key role in building a targeted degradation platform. He has led teams in expressing and purifying protein targets for use in hundreds of drug discovery projects.

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Science DNA Disease International 52

Agency IQ

MARCH 29, 2024

Similarly, the Group I and II Polymers and Resins NESHAP were most recently updated when the agency conducted its RTR on December 16, 2008, and April 21, 2011. The HON standards were most recently updated when the agency conducted a residual risk and technology review (RTR) on December 21, 2006.

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Regulations Compliance Production Government 40

Codon

AUGUST 10, 2023

Nature (2011). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link Recent advances in DNA assembly technologies , by Chao R.

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DNA Cell Biology Molecular Biology Engineering 98

Codon

AUGUST 10, 2023

Nature (2011). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link Recent advances in DNA assembly technologies , by Chao R.

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DNA Cell Biology Engineering Molecular Biology 52

Codon

MARCH 16, 2025

Today, decades after the invention of DNA sequencing, it is easy to take the accessibility of genomic data for granted. But in the early 1990s, when Guilford’s group began collecting blood and tumor samples from the MacLeods, DNA sequencing technology was still costly and unwieldy.

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DNA Disease Medical Schools Hospitals 112

Drug & Device Law

DECEMBER 19, 2022

604, 620 (2011) (“The question for ‘impossibility’ is whether the private party could independently do under federal law what state law requires of it.”). See PLIVA, Inc. Mensing , 564 U.S. 2) These changes include, but are not limited to: * * * *.

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FDA Regulations Production Drugs 59