National Institute on Drug Abuse: Nora's Blog

FEBRUARY 8, 2023

Pregnant People With Substance Use Disorders Need Treatment, Not Criminalization mfleming Wed, 02/08/2023 - 15:33 Nora's Blog February 15, 2023 Image ©Getty Images/ Caia Image This blog was also published in STAT on February 8, 2023. People seeking treatment for addictions face additional obstacles, especially if they have children.

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The Pharma Data

OCTOBER 14, 2021

COBRA study subgroups results presented at the 37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS). There’s historically limited clinical safety data for babies who are breastfed by maters witnessing treatment for MS including during the gestation period. NYSE and TASE TEVA) andSt.

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Drug Target Review

NOVEMBER 27, 2023

In cancer, the eIF4F complex becomes dysregulated, leading to the excessive production of these proteins, which contribute to tumour formation and resistance to treatment. STRIs represent a fundamentally different approach to cancer therapy compared to traditional treatments like chemotherapy, radiation therapy, and targeted therapies.

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Drug Target Review

DECEMBER 1, 2023

The advancement could have great impact in making treatments using MSCs more accessible and efficient, for osteoarthritis, autoimmune and infectious diseases, and neurological disorders. “This will significantly accelerate the development of cutting-edge treatments and improve accessibility for cell therapy.”

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The Pharma Data

MAY 14, 2021

Product Name: Hives Urticaria & Angioedema Treatment Protocol | Cure & Relief. Hives Urticaria & Angioedema Treatment Protocol | Cure & Relief is backed with a 60 Day No Questions Asked Money Back Guarantee. They try every known cure, treatment, and medically accepted idea — yet NOTHING works!

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New Drug Approvals

NOVEMBER 13, 2023

WO 2017/208267A1, WO 2020/250133 Al and WO 2022/024072A1, which are hereby incorporated by reference, disclose methods of use of the compound of Formula I for the treatment of Parkinson’s disease, synucleinopathies and Alzheimer’s disease (AD) respectively. amcrasto@amcrasto /////////// Ref [1]. amcrasto@amcrasto /////////// Ref [1].

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Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. His mother had a presentation of the disease that suggested her immune system was already on the job.

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SCIENMAG: Medicine & Health

SEPTEMBER 27, 2023

In advanced cases, the only treatment is an organ transplant. Credit: Copyright © 2011 Michael Bonert […] Over time, accumulating scarring distorts the liver, interferes with its blood supply and may progressively lead to worsening consequences, from cirrhosis to liver failure to liver cancer.

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New Drug Approvals

SEPTEMBER 8, 2024

5 On August 14, 2024, seladelpar was granted accelerated approval by the FDA for the treatment of primary biliary cholangitis, 6 which is a condition associated with aberrant bile acid metabolism. July 2024). “Seladelpar treatment reduces IL-31 and pruritus in patients with primary biliary cholangitis” Hepatology.

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Drug Target Review

JULY 24, 2023

The study suggests that this regulatory system could be a potential target for future malaria treatments, offering hope for combatting this deadly disease that affects millions worldwide. With this newfound knowledge, there is renewed hope in the pursuit of effective malaria treatments alleviating the suffering of millions affected.

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The Pharma Data

DECEMBER 21, 2020

21 December 2020 — AstraZeneca’s Tagrisso ( osimertinib ) has been approved in the US for the adjuvant treatment of adult patients with early-stage epidermal growth factor receptor-mutated (EGFRm) non-small cell lung cancer (NSCLC) after tumour resection with curative intent. 0.23; p<0.0001).

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The Pharma Data

AUGUST 17, 2021

In the Opdivo plus Yervoy arm, patients received treatment with Opdivo 3 mg/kg every 2 weeks and Yervoy 1 mg/kg every 6 weeks up to 24 months or until disease progression or unacceptable toxicity. By harnessing the body’s own immune system to fight cancer, Opdivo has become an important treatment option across multiple cancers.

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Common Sense for Drug Policy Blog

JANUARY 5, 2024

This estimate is more than 5 times the most recent US estimate of ∼774,000 from 2011 [ 25 ]. Much of this increase is likely attributable to increases in IDU, but it is important to consider methodological differences in the creation of this 2018 estimate vs the 2011 estimate. during the past decade.

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The Pharma Data

NOVEMBER 30, 2020

30, 2020 — For colon cancer patients, Medicaid expansion is associated with earlier diagnosis, enhanced access to treatment, and improved surgical care, according to a study published online Nov. Medicaid and uninsured patients aged 40 to 64 years were compared preexpansion (2011 to 2012) and postexpansion (2015 to 2016).

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Broad Institute

AUGUST 31, 2023

The editing molecules are also smaller, potentially making it easier to deliver them into cells in key parts of the body as new disease treatments. The method involves growing a diversity of rapidly evolving bacteriophages — the viruses that infect bacteria — in laboratory “lagoons” that undergo continuous dilution.

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The Pharma Data

JANUARY 4, 2021

from Texas Children’s Hospital and Baylor College of Medicine in Houston, and colleagues conducted a comparative cross-sectional study using electronic health records from a tertiary care hospital between 2011 and 2016 to characterize anxiety, depression, and ADHD among youth with versus without CHD. Gonzalez, M.D.,

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Drug Target Review

NOVEMBER 1, 2023

The mission of the CCDD is to discover novel small-molecule therapeutics for the treatment of cancer and progress them to hypothesis testing phase 1 clinical trials. 2011) D67, 386-394) using PDB ID 4GV1 which was published as part of Addie et al. Although we are an academic centre we work very much like industry. Acta Cryst.

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Drug Target Review

SEPTEMBER 4, 2023

Plants are not well exploited for the treatment of infectious agents, and inter-species biochemical processes and infectious agents habitat interaction are not well studied. 2011): State of the Art in African Trypanosome Drug Discovery, Current topic of medical chemistry. Deadly sniper-treated beans: Matters arising, TheGuardian.

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Broad Institute

AUGUST 25, 2023

Thanks to the generous funding from Ted and Vada Stanley, and the collaborative environment of the Broad Institute, researchers at the Stanley Center have made strides toward understanding severe psychiatric disease with the goal of contributing to new understandings of pathogenesis, the identification of biomarkers, and above all, new treatments.

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The Pharma Data

NOVEMBER 2, 2020

adults by using blood pressure (BP) thresholds from the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC7) and the 2017 American College of Cardiology-American Heart Association (ACC-AHA) BP guidelines.

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Pharmaceuticals Treatment Disease Research 52

The Pharma Data

JANUARY 20, 2021

20, 2021 — In what may signal a seismic shift in the treatment of methamphetamine addiction, a pair of prescription drugs appears to help patients significantly reduce their stimulant use, or quit altogether. Standard behavioral treatment for meth addiction typically involves highly structured group therapy, Volkow explained.

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New Drug Approvals

AUGUST 21, 2023

5] Medical uses Palovarotene is indicated for the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva. [4] 19] In January 2023, the European Medicines Agency (EMA) recommended the refusal of the marketing authorization for palovarotene for the treatment of fibrodysplasia ossificans progressiva. [20]

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FDA Clinical Trials Treatment Pharmaceuticals 52

The Pharma Data

JANUARY 14, 2021

The approval was based on data from Study ADVL0912, a multicenter, single-arm, open-label trial in 121 patients ranging in ages from one to 21, and included 26 patients with r/r/, systemic ALK-positive ALCL after at least one systemic treatment. The data showed an objective response rate of 88%. Most Read Today. Source link.

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Codon

AUGUST 26, 2024

In 2011, research groups at the MIT Lincoln Laboratory and Boston University fused together two different proteins to make broad antivirals: one protein binds to double-stranded RNA, and the other triggers apoptosis, or cell death. This exponential infection dynamic poses a challenge for existing broad-spectrum antiviral treatments.

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Drug Target Review

JUNE 19, 2024

Our goal is to stand on the shoulders of giants and advance this exciting and new field of medicine, so that it can deliver valuable treatments to patients. How do you envision the future of cell therapy and its potential impact on medical treatments and healthcare? Could you give us an overview of the Lineage platform?

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Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

Drug Target Review

APRIL 23, 2024

As a result, drug developers can expedite the path to clinical and commercial stages, meaning patients will receive essential treatments at accelerated rates. Having this insight before ‘wet lab’ testing can help introduce significant time and cost savings. – MatchTrial, accessed 26 February 2024, from: [link] Hughes, J. Kalindjian, S.

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The Pharma Data

AUGUST 11, 2020

We look forward to engaging health authorities worldwide with the goal of bringing this immunotherapy-based treatment option to patients as soon as possible.”. All patients continued treatment for two years or until disease progression, unacceptable toxicity or withdrawal of consent. Waxman, M.D., About Esophageal Cancer.

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New Drug Approvals

SEPTEMBER 13, 2024

2] Like other kappa opioid antagonists currently under clinical investigation for the treatment of major depression, its efficacy may be compromised by the countervailing activation of pro-inflammatory cytokines in microglia within the CNS. [7] 2] It first appeared in the scientific literature in 2010 or 2011. [16] nM vs. 24.0

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The Pharma Data

NOVEMBER 30, 2020

It’s a simple concept: After a health care provider explains various details on treatment plans, medications and how to manage the disease at home, they then ask the patient to repeat back the information. Data came from the 2011-2016 Medical Expenditure Panel Survey administered by the U.S.

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The Pharma Data

APRIL 27, 2023

We are encouraged by the CHMP’s positive recommendation, which puts us one step closer to offering patients in the EU a first-in-class treatment for obstructive HCM, and reinforces our commitment to delivering transformative cardiovascular therapies to patients worldwide.”

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FDA Law Blog: Biosimilars

SEPTEMBER 15, 2024

The PREVAIL Act In short, the PREVAIL Act is intended to, among other things, reform the Inter Partes Review (“IPR”) process created by the 2011 Leahy-Smith America Invents Act. 2220, the Promoting and Respecting Economically Vital American Innovation Leadership Act (“ PREVAIL Act ”); and (2) S. inventors to compete.

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The Pharma Data

DECEMBER 16, 2020

The FDA first approved Benlysta for lupus in 2011. Effective treatment can greatly improve health outcomes and reduce the long-term costs associated with managing lupus-related kidney disease.” Up to 60 percent of people with lupus will develop lupus nephritis. Gibson , president and CEO, Lupus Foundation of America.

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The Pharma Data

JANUARY 14, 2021

The biggest obstacle to getting prompt treatment is delay before patients call the ambulance, the researchers said. ” For the study, the researchers collected data on more than 3,100 heart attack patients who had angioplasties between 2002 and 2011. Patients were followed for a median of about a year. © 2021 HealthDay.

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The Pharma Data

DECEMBER 13, 2020

We will continue to work closely with the Agency to potentially bring margetuximab as a treatment option to patients with HER2-positive metastatic breast cancer.”. The biosimilar is a collaboration between Amgen and Allergan, which was formed when Allergan was Watson Pharmaceuticals in December 2011. The drug is an anti-CD20 antibody.

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The Pharma Data

FEBRUARY 22, 2022

After ten years at Sony France as Chief Financial Officer (2000-2002), and then General Secretary, she was appointed Chief Financial Officer of Europacorp Group in 2011. She began her career in 1992 at PricewaterhouseCoopers where she worked as an auditor and then a financial advisor. Sanofi is listed on EURONEXT: SAN and NASDAQ: SNY.

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Clinical Trials DNA Science Clinical Development 52

Drug Target Review

JUNE 21, 2023

4 For the treatment of rare genetic disorders especially, drugs with genetically supported targets are more than twice as likely to be approved 5 , thereby indicating genetics and genomics can empower companies to develop better drugs. Nature 477 , 220–224 (2011). 2009 Nov 27;326(5957):1231-5. doi: 10.1126/science.1178955.

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The Pharma Data

NOVEMBER 10, 2020

Hydrogen-Oxygen Inhalation for Treatment of COVID-19, a monograph concluding China’s experience in the fight against COVID-19, reports that Hydrogen Oxygen Generator with Nebulizer is effective in treating patients with COVID-19 coronavirus. SHANGHAI , Nov.

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