Covalent Modifiers

NOVEMBER 18, 2024

In this review, we introduce the biological functions of IDH, describe the tumorigenesis mechanisms of IDH variants, and review the structure-based drug discovery of clinical inhibitors during 2012-2024. We also find successful applications of covalent strategy in the development of irreversible IDH inhibitors.

Drugs 58

Drugs Research 58

Drugs.com

MARCH 7, 2024

new report of data from 2012 through 2021 finds a. THURSDAY, March 7, 2024 -- As more Americans pop over-the-counter melatonin to help them sleep, their young children are increasingly showing up in ERs after accidentally ingesting the supplements.A

98

98

Common Sense for Drug Policy Blog

NOVEMBER 15, 2024

Cathinones first appeared in our sample in 2010 but predominated from 2012–2016, when they were detected in more than one-sixth (17 %) of samples. Pseudo/ephedrine detections peaked in 2004 (17 %) but practically disappeared after 2006, when the federal ban on over-the-counter pseudoephedrine sales took effect ( Rigdon, 2012 ).

Marketing 52

Marketing Pharmaceuticals Drugs 52

Drugs.com

NOVEMBER 7, 2023

Rates of congenital syphilis soared 10-fold between 2012 and 2022, according. TUESDAY, Nov. 7, 2023 -- An old scourge, syphilis, is returning with a vengeance in the United States, affecting not only adults but also the most vulnerable -- newborns.

105

105

Common Sense for Drug Policy Blog

OCTOBER 21, 2024

2012 ; Ruiz-Colón et al., 2012 ; Rodríguez et al., Xylazine in the Unregulated Drug Supply "Xylazine is a veterinary tranquilizer, which is not approved for human use in the United States, but is commonly used for sedating large animals ( Reyes et al., 2008 ; Torruella, 2011 ).

Drugs 52

Drugs 52

Common Sense for Drug Policy Blog

NOVEMBER 8, 2024

The number of allegations rose 121% from 2013 to 2016, which was partly attributable to correctional authorities’ continuing response to the 2012 release of the National Standards to Prevent, Detect, and Respond to Prison Rape. dwf_admin Fri, 11/08/2024 - 12:11 Source Emily D.

52

52

NIOSH Science Blog: Drugs

JANUARY 10, 2024

Unintentional overdose from the nonmedical use of drugs resulted in 388 worker deaths in 2020, an increase of nearly 500 percent from 2012. The drug overdose epidemic is occurring in and impacting workplaces.

Treatment 92

Treatment Drugs 92

SCIENMAG: Medicine & Health

MARCH 4, 2024

According to the National Health Insurance Service report covering the years from 2012 to 2022, there has been a 22.8% Degenerative arthritis is no longer exclusive to the elderly population. increase in the prevalence of degenerative arthritis among people in their 20s and 30s.

69

69

Broad Institute

MARCH 8, 2024

Hung (2010 - 2011 awardee) James Bradner Jake Jaffe 2011 - 2012 Awardees Feng Zhang John Rinn Mitchell Guttman Anne Carpenter 2010 - 2011 Awardees Deborah T. Any questions about the Next Generation Awards program can be directed to Jacob Herman at jherman@broadinstitute.org.

Research 52

Research 52

Drug Hunter

MAY 21, 2023

One notable example comes from an HIV reverse transcriptase program led by Andy Peat, then at GSK, in 2012. This tour-de-force review from Yoshihiro Ishihara of Vividion Therapeutics and Debora Chiodi at Scripps compiles examples of chlorine atoms exerting outsized effects on SAR.

Trials 144

Trials Drugs 144

Agency IQ

JUNE 21, 2024

While this policy has been in place since 2012 for drug facilities, the same authority was only extended to FDA’s oversight of medical devices in 2017. The FDA has now finalized a revision to its guidance on the subject to provide more examples and incorporate device considerations.

FDA 59

FDA Production Drugs 59

NIOSH Science Blog: Drugs

MARCH 27, 2024

Future Day was first celebrated worldwide on March 1, 2012 as a forward-looking reflection on all the possibilities the future holds for humanity.1 1 Just two years later, the global think tank Millennium Project helped expand the unofficial holiday into what is now recognized as World Futures Day.2

International 67

International 67

Science Daily: Pharmacology News

SEPTEMBER 15, 2023

An antibody developed in 2012 to target only the toxic protein while leaving its healthy counterpart unscathed is currently undergoing clinical trials in human patients suffering from traumatic brain injury and Alzheimer's Disease. Experts pinpointed a toxic protein named cis P-tau in the blood and placenta of individuals with preeclampsia.

Research 87

Research Clinical Trials Trials Treatment 87

Common Sense for Drug Policy Blog

DECEMBER 14, 2023

Notably, no major changes were apparent in the distribution of substances, on average, between 2012 and 2019, as reported in the literature. Specifically, the category of prescription drugs decreased in proportion, becoming the second smallest proportion of listings, from over 20% between 2012 and 2019 to under 5% between 2022 and 2023.

Marketing 40

Marketing Drugs Science 40

Common Sense for Drug Policy Blog

AUGUST 9, 2023

Age-period-cohort decomposition found rapid increases in mortality since 2012 in men and women, with higher mortality risk in cohorts born after 1990.

Drugs 52

Drugs 52

Chemical Biology and Drug Design

APRIL 16, 2023

Among numerous vesicular systems, concept of transethosomes (TEs) introduced in 2012 are being tested for drug delivery to the dermis. The formulation scientist has developed a vesicular system to enhance the skin's absorption of bioactive substances. When transferosomes and ethosomes interact, TEs are produced.

Drugs 100

Drugs Compliance Research Marketing 100

Agency IQ

JANUARY 26, 2024

In 2012, the EPA issued its first official Scientific Integrity Policy (2012 SIP). The agency also appointed its first Scientific Integrity Official (SIO) in the wake of the 2012 SIP. The policy will replace the 2012 SIP and reaffirm the role of the EPA’s SIO and deputy SIOs around the agency.

Science 40

Science Government Production International 40

Science Daily: Pharmacology News

JUNE 8, 2023

gigatonnes (or billion metric tonnes) of carbon dioxide being released into the atmosphere on average every year over the last decade (2012-2021). The analysis also found that greenhouse gas emissions were 'at an all-time high', with human activity resulting in the equivalent of 54 (+/-5.3)

75

75

Agency IQ

SEPTEMBER 22, 2023

Regulatory background Biocides are regulated primarily by the Biocidal Products Regulation (BPR) (528/2012/EU). It appears the issue is largely the result of unclear labeling for biocidal disinfectants, an aspect French regulators may flag in future market authorization evaluations for these products.

Regulations 59

Regulations Production Marketing 59

Agency IQ

JULY 26, 2024

EU executive consults on proposed update to PIC chemical lists Regulation (EU) 649/2012 (PIC Regulation) is the main act on the export and import of hazardous chemicals between the European Union and third countries.

Regulations 40

Regulations International Packaging Compliance 40

Agency IQ

SEPTEMBER 1, 2023

Regulatory background The Prior Informed Consent Regulation (EU) 649/2012 (PIC) is the main act on the export and import of hazardous chemicals between the European Union and third countries.

Regulations 52

Regulations International 52

Perficient: Drug Development

AUGUST 15, 2023

Prior to Windows Server 2012, there were a couple of challenges when it comes to hosting secure sites: SSL Scalability: In a multi-tenanted environment, such as a shared hosting, there is a limitation as to how many secure sites can be hosted on Windows Server, resulting in a low site-density.

Production 96

Production 96

The Pharma Data

JANUARY 15, 2021

15, 2021 — After publication of the 2012 guidelines defining vasectomy success as either azoospermia or rare nonmotile sperm, men undergoing vasectomy had a lower risk for requiring any repeat postvasectomy semen analysis, according to a study published online Jan. Professional. FRIDAY, Jan. 12 in Urology Practice. Tony Chen, M.D.,

Research 52

Research 52

Drug Target Review

APRIL 4, 2024

Nicholas continued to serve as CEO of NeuroSearch Sweden through 2012. Nicholas served as the CEO of IRLAB Sweden between 2012 and 2022 and for IRLAB therapeutics 2016-2022. In 2010 he was appointed Executive Vice President, Research at NeuroSearch. In 2013, Nicholas co-founded IRLAB Sweden.

Disease 105

Disease Treatment Licensing Licensing 105

Common Sense for Drug Policy Blog

DECEMBER 5, 2023

residents of all ages) was down 26% from yearend 2012 (480 per 100,000) but up 1% from yearend 2021 (350 per 100,000). "ƒ In 2022, states and the BOP admitted 469,200 persons to prison, which was 20,800 more than they released that year (448,400) and 48,200 more than they admitted the year before (421,000)."

52

52

Drug Channels

DECEMBER 14, 2021

Since 2012, Drug Channels has examined commercial drug spending using the annual trend reports published by the largest PBMs. This week, I’m rerunning some popular posts while I prepare for this Friday’s live video webinar: Drug Channels Outlook 2022. Click here to see the original post and comments from July 2021.

Pharmacy 82

Pharmacy Drugs 82

Drug Target Review

OCTOBER 26, 2023

Alipogene tiparvovec and voretigene neparvovec-rzyl, two recombinant AAV-based gene therapy products, were approved by the European Medicines Agency (EMA) to treat lipoprotein lipase deficiency in 2012 2 and by the US Food and Drug Administration (FDA) to treat inherited retinal dystrophy in 2017, respectively. Nature 578 , 229-236 (2020).

Engineering 105

Engineering Virus Therapies Immune Response 105

Agency IQ

SEPTEMBER 1, 2023

BY SCOTT STEPHENS, MPAAUG 30, 2023 3:38 PM CDT Regulatory background The Prior Informed Consent Regulation (EU) 649/2012 (PIC) is the main act on the export and import of hazardous chemicals between the European Union and third countries.

Regulations 40

Regulations Production International 40

The Pharma Data

DECEMBER 3, 2020

3, 2020 — From 2012 to 2016, there was an increase in the percentage of Medicare beneficiaries on long-term dialysis who were aligned to an accountable care organization (ACO), with a reduction in spending seen for ACO-aligned beneficiaries, according to a study published online Nov. Professional. THURSDAY, Dec.

Research 52

Research Disease 52

FDA Law Blog: Biosimilars

AUGUST 10, 2023

Section 704(a)(4) was added to the FDCA by the Food and Drug Administration Safety and Innovation Action (FDASIA) in July 2012. Despite FDA having the authority to conduct paper inspections since the statutory provision was added to the FDCA by FDASIA in 2012, FDA did not issue a warning letter citing Section 704(a)(4) until January 2021.

FDA 52

FDA Drugs Production 52

Elrig

SEPTEMBER 26, 2024

Zero Waste-to-Landfill: ExCeL has had a zero-waste-to-landfill policy since 2012, with 71% of waste recycled and the rest used to create refuse-derived fuels. Water Conservation: Their waterless urinals save enough water annually to fill 6 Olympic-sized swimming pools.

Drugs 40

Drugs 40

Perficient: Drug Development

AUGUST 24, 2023

Understanding GraphQL: At its core, GraphQL is a query language and runtime for APIs that was developed by Facebook in 2012 and later open-sourced in 2015. In this comprehensive exploration, we’ll dive deep into the essence of GraphQL, its core principles, benefits, and real-world applications.

Production 98

Production 98

Drug Channels

JULY 14, 2021

Since 2012, Drug Channels has examined commercial drug spending using the annual trend reports published by the largest PBMs. This year, we review 2020 data on commercial plan sponsor clients of CVS Health and Express Scripts along with two smaller PBMs—Navitus and WellDyne.

Pharmacy 52

Pharmacy Drugs 52

Broad Institute

JULY 13, 2023

Nature Methods, 2012]. Nature Methods, 2012]. Credit: Image set BBBC033v1 from Rivron et al. 2018, available from the Broad Bioimage Benchmark Collection [Ljosa et al., Human red blood cells imaged using differential interference contrast microscopy. Previous Next What inspired you all to create the guide?

Molecular Biology 98

Molecular Biology Laboratories Research 98

Policy Prescription

JANUARY 31, 2022

Despite the law requiring the reporting of suspicious orders, the Gazette-Mail reported that between 2001-2012 the board received only two reports , both from Cardinal Health. In West Virginia, by 2012 big wholesaler pharmacies were under investigation by the state attorney general: and then the suspicious order reports began to come in.

Pharmacy 52

Pharmacy Regulations Doctors Drugs 52

Common Sense for Drug Policy Blog

JANUARY 1, 2024

Our projection of medical cost savings of $229,800 is substantially lower than the previous estimate of $303,100 in 2004 US dollars ($361,400 in 2012 US dollars) [ 7 ] for several reasons. First, we now account for medical costs that would have been incurred in the absence of an HIV infection.

Treatment 40

Treatment Drugs 40

Agency IQ

AUGUST 30, 2024

the public classification and labeling (C&L) inventory, cost elements in data sharing under REACH, compliance with the CLP when manufacturing candles); and (3) “ Guidance in a nutshell ,” which, as the title implies, presents a concise rundown of various chemicals legislation features.

Compliance 40

Compliance Regulations Packaging Production 40