Broad Institute

MARCH 8, 2024

Hung (2010 - 2011 awardee) James Bradner Jake Jaffe 2011 - 2012 Awardees Feng Zhang John Rinn Mitchell Guttman Anne Carpenter 2010 - 2011 Awardees Deborah T. Any questions about the Next Generation Awards program can be directed to Jacob Herman at jherman@broadinstitute.org.

Research 52

Research 52

NIOSH Science Blog: Drugs

JANUARY 10, 2024

Unintentional overdose from the nonmedical use of drugs resulted in 388 worker deaths in 2020, an increase of nearly 500 percent from 2012. The drug overdose epidemic is occurring in and impacting workplaces.

Treatment 86

Treatment Drugs 86

Drug Hunter

MAY 21, 2023

One notable example comes from an HIV reverse transcriptase program led by Andy Peat, then at GSK, in 2012. This tour-de-force review from Yoshihiro Ishihara of Vividion Therapeutics and Debora Chiodi at Scripps compiles examples of chlorine atoms exerting outsized effects on SAR.

Trials 144

Trials Drugs 144

NIOSH Science Blog: Drugs

MARCH 27, 2024

Future Day was first celebrated worldwide on March 1, 2012 as a forward-looking reflection on all the possibilities the future holds for humanity.1 1 Just two years later, the global think tank Millennium Project helped expand the unofficial holiday into what is now recognized as World Futures Day.2

International 65

International 65

Common Sense for Drug Policy Blog

DECEMBER 14, 2023

Notably, no major changes were apparent in the distribution of substances, on average, between 2012 and 2019, as reported in the literature. Specifically, the category of prescription drugs decreased in proportion, becoming the second smallest proportion of listings, from over 20% between 2012 and 2019 to under 5% between 2022 and 2023.

Marketing 40

Marketing Drugs Science 40

Drug Discovery World

NOVEMBER 13, 2023

Typhi samples obtained from people with confirmed typhoid fever from 2012 to 2019, plus an extra 10 from clinical infections in the UK that were associated with travel to Zimbabwe. Working with local health authorities in Harare, they sequenced the genomes of 85 S.

Vaccine 130

Vaccine International Treatment Disease 130

Science Daily: Pharmacology News

SEPTEMBER 15, 2023

An antibody developed in 2012 to target only the toxic protein while leaving its healthy counterpart unscathed is currently undergoing clinical trials in human patients suffering from traumatic brain injury and Alzheimer's Disease. Experts pinpointed a toxic protein named cis P-tau in the blood and placenta of individuals with preeclampsia.

Research 84

Research Clinical Trials Trials Treatment 84

Drug Discovery World

DECEMBER 7, 2022

In the first 10 months of 2022, there were more than 225 new trials, compared with 125 in 2012. A new report reveals steadily growing interest in the clinical applications of collagen over the last 10 years. . Data analytics company Phesi analysed 2,358 clinical trials involving collagen.

Clinical Trials 130

Clinical Trials Trials Clinical Research Clinical Development 130

Common Sense for Drug Policy Blog

AUGUST 9, 2023

Age-period-cohort decomposition found rapid increases in mortality since 2012 in men and women, with higher mortality risk in cohorts born after 1990.

Drugs 52

Drugs 52

Drug Discovery World

AUGUST 30, 2022

Emily Whitehead became the first child in the world to receive the revolutionary cell therapy treatment named CAR-T in 2012 as a last hope to cure her of leukaemia – she remains in remission 10 years later. Here are a few of many discussions and events to earmark. How CAR-T became synonymous with commercial success.

Therapies 246

Therapies Hospitals Clinical Trials Clinical Development 246

Common Sense for Drug Policy Blog

SEPTEMBER 8, 2023

When examining the historical trends of annual prevalence, we found a declining trend in reports of drug seizure from 7% in 2009 to 3% in 2012, while the prevalence between June 2019 and mid-March 2020 and between June and November of 2021 (4–5%) remained essentially the same as the annual prevalence in 2011–2012.

Drugs 52

Drugs Marketing 52

Chemical Biology and Drug Design

APRIL 16, 2023

Among numerous vesicular systems, concept of transethosomes (TEs) introduced in 2012 are being tested for drug delivery to the dermis. The formulation scientist has developed a vesicular system to enhance the skin's absorption of bioactive substances. When transferosomes and ethosomes interact, TEs are produced.

Compliance 100

Compliance Drugs Research Marketing 100

Agency IQ

JANUARY 26, 2024

In 2012, the EPA issued its first official Scientific Integrity Policy (2012 SIP). The agency also appointed its first Scientific Integrity Official (SIO) in the wake of the 2012 SIP. The policy will replace the 2012 SIP and reaffirm the role of the EPA’s SIO and deputy SIOs around the agency.

Science 40

Science Government Production International 40

Science Daily: Pharmacology News

JUNE 8, 2023

gigatonnes (or billion metric tonnes) of carbon dioxide being released into the atmosphere on average every year over the last decade (2012-2021). The analysis also found that greenhouse gas emissions were 'at an all-time high', with human activity resulting in the equivalent of 54 (+/-5.3)

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Agency IQ

SEPTEMBER 22, 2023

Regulatory background Biocides are regulated primarily by the Biocidal Products Regulation (BPR) (528/2012/EU). It appears the issue is largely the result of unclear labeling for biocidal disinfectants, an aspect French regulators may flag in future market authorization evaluations for these products.

Regulations 59

Regulations Production Marketing 59

Common Sense for Drug Policy Blog

SEPTEMBER 8, 2023

In 2009–2012, 67.8% Odds of drug seizure were not significantly different between the two time periods (2019–2021 vs. 2009–2012) (AOR: 0.93; 95% CI: 0.64–1.35)." In multivariable analyses, factors significantly associated with drug seizure included: homelessness (adjusted odds ratio [AOR]: 1.98; 95% confidence interval [CI] 1.09–3.61),

Drugs 40

Drugs Marketing 40

Drug Target Review

APRIL 4, 2024

Nicholas continued to serve as CEO of NeuroSearch Sweden through 2012. Nicholas served as the CEO of IRLAB Sweden between 2012 and 2022 and for IRLAB therapeutics 2016-2022. In 2010 he was appointed Executive Vice President, Research at NeuroSearch. In 2013, Nicholas co-founded IRLAB Sweden.

Disease 105

Disease Treatment Licensing Licensing 105

Agency IQ

SEPTEMBER 1, 2023

Regulatory background The Prior Informed Consent Regulation (EU) 649/2012 (PIC) is the main act on the export and import of hazardous chemicals between the European Union and third countries.

Regulations 52

Regulations International 52

Perficient: Drug Development

AUGUST 15, 2023

Prior to Windows Server 2012, there were a couple of challenges when it comes to hosting secure sites: SSL Scalability: In a multi-tenanted environment, such as a shared hosting, there is a limitation as to how many secure sites can be hosted on Windows Server, resulting in a low site-density.

Production 96

Production 96

Common Sense for Drug Policy Blog

DECEMBER 5, 2023

residents of all ages) was down 26% from yearend 2012 (480 per 100,000) but up 1% from yearend 2021 (350 per 100,000). "ƒ In 2022, states and the BOP admitted 469,200 persons to prison, which was 20,800 more than they released that year (448,400) and 48,200 more than they admitted the year before (421,000)."

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The Pharma Data

JANUARY 15, 2021

15, 2021 — After publication of the 2012 guidelines defining vasectomy success as either azoospermia or rare nonmotile sperm, men undergoing vasectomy had a lower risk for requiring any repeat postvasectomy semen analysis, according to a study published online Jan. Professional. FRIDAY, Jan. 12 in Urology Practice. Tony Chen, M.D.,

Research 52

Research 52

Drug Target Review

OCTOBER 26, 2023

Alipogene tiparvovec and voretigene neparvovec-rzyl, two recombinant AAV-based gene therapy products, were approved by the European Medicines Agency (EMA) to treat lipoprotein lipase deficiency in 2012 2 and by the US Food and Drug Administration (FDA) to treat inherited retinal dystrophy in 2017, respectively. Nature 578 , 229-236 (2020).

Engineering 104

Engineering Virus Therapies Immune Response 104

Agency IQ

SEPTEMBER 1, 2023

BY SCOTT STEPHENS, MPAAUG 30, 2023 3:38 PM CDT Regulatory background The Prior Informed Consent Regulation (EU) 649/2012 (PIC) is the main act on the export and import of hazardous chemicals between the European Union and third countries.

Regulations 40

Regulations Production International 40

FDA Law Blog: Biosimilars

AUGUST 10, 2023

Section 704(a)(4) was added to the FDCA by the Food and Drug Administration Safety and Innovation Action (FDASIA) in July 2012. Despite FDA having the authority to conduct paper inspections since the statutory provision was added to the FDCA by FDASIA in 2012, FDA did not issue a warning letter citing Section 704(a)(4) until January 2021.

FDA 52

FDA Drugs Production 52

The Pharma Data

DECEMBER 3, 2020

3, 2020 — From 2012 to 2016, there was an increase in the percentage of Medicare beneficiaries on long-term dialysis who were aligned to an accountable care organization (ACO), with a reduction in spending seen for ACO-aligned beneficiaries, according to a study published online Nov. Professional. THURSDAY, Dec.

Research 52

Research Disease 52

Common Sense for Drug Policy Blog

JANUARY 1, 2024

Our projection of medical cost savings of $229,800 is substantially lower than the previous estimate of $303,100 in 2004 US dollars ($361,400 in 2012 US dollars) [ 7 ] for several reasons. First, we now account for medical costs that would have been incurred in the absence of an HIV infection.

Treatment 40

Treatment Drugs 40

Drug Target Review

JANUARY 8, 2024

Shinya Yamanaka, who was awarded the Nobel prize in 2012, discovered that four transcription factors Oct4, Sox2, Klf4 and c-Myc could reprogram mature, differentiated cells back into stem cells. The epigenome drifts with age, leading to dysregulated gene expression.

Science 145

Science Disease FDA Approval DNA 145

Drug Discovery World

OCTOBER 27, 2022

Panellists discussed what they were hoping to achieve a decade ago, what they anticipate for the future, and the inflection points along the way.

Therapies 130

Therapies Hospitals Disease Trials 130

Policy Prescription

JANUARY 31, 2022

Despite the law requiring the reporting of suspicious orders, the Gazette-Mail reported that between 2001-2012 the board received only two reports , both from Cardinal Health. In West Virginia, by 2012 big wholesaler pharmacies were under investigation by the state attorney general: and then the suspicious order reports began to come in.

Pharmacy 52

Pharmacy Regulations Doctors Drugs 52

LifeSciVC

APRIL 26, 2024

This has long been a feature of biopharma (see 2012 and 2016 posts on oncology and immune-oncology , respectively), but has been exacerbated by the creation of so many new companies. Third, with the proliferation of startups, we’ve seen incredible crowding in hyper-competitive therapeutic categories and modalities.

DNA 112

DNA Science Marketing Clinical Trials 112

Agency IQ

JUNE 21, 2024

While this policy has been in place since 2012 for drug facilities, the same authority was only extended to FDA’s oversight of medical devices in 2017. The FDA has now finalized a revision to its guidance on the subject to provide more examples and incorporate device considerations.

FDA 40

FDA Production International Drugs 40

The Pharma Data

SEPTEMBER 27, 2021

The number of dispensed prescriptions for opioid analgesics has been steadily declining from a peak of 84 prescriptions per 100 residents in 2012 to 43 prescriptions per 100 residents in 2020. A wide sort of interventions intended to scale back inappropriate or unnecessary prescribing, including prescriber education initiatives.

FDA 52

FDA Treatment Research Drugs 52

The Pharma Data

JANUARY 24, 2021

Established in 2012, Samsung Bioepis has rapidly grown to have five biologic products in immunology and oncology with more than 215,000 patients treated with the company’s immunology products in Europe alone. Established in 2012, Samsung Bioepis is a biopharmaceutical company committed to realizing healthcare that is accessible to everyone.

Biosimilars 52

Biosimilars Laboratories Production 52

Drug Discovery World

NOVEMBER 20, 2023

mAbs, 2012, 4, 445-457.   Wang et al., Therapeutic monoclonal antibodies approved or in review in the EU or US. date accessed 5 September 2023).   Ducancel & Muller, Molecular engineering of antibodies for therapeutic and diagnostic purposes. Optimization of therapeutic antibodies. Antibody Therapeutics, 2021, 4, 45-54.  

DNA 173

DNA Engineering Vaccine Therapies 173

FDA Law Blog: Biosimilars

MAY 13, 2024

Based on a review of premarket submissions made in 2012 through 2019, FDA identified 90 examples of 510(k)s, De Novos, HDEs, and PMAs approved/cleared which utilized RWE in support of regulatory decision-making. During this period the estimated total number of such submissions was approximately 26,121.

FDA 111

FDA Production Trials Pharmacy 111

Agency IQ

OCTOBER 6, 2023

Codes starting with 3 are for facilities conducting activities covered by the EU’s Industrial Emissions Directive (EU) 2010/75 (IED), and codes starting with 4 are for facilities with substances covered by the Seveso III Directive 2012/18/EU.

Pharmaceuticals 40

Pharmaceuticals Regulations Production Packaging 40

Common Sense for Drug Policy Blog

DECEMBER 14, 2023

To offer insight into and characterize Dark Web markets, we conducted a study of the substances available on the Dark Web, both historically—between 2012 and 2019—and at present, between 2022 and 2023. The substances, in addition to the markets themselves, that are available on the Dark Web at any given time are difficult to predict.

Marketing 40

Marketing Drugs Science Treatment 40