Drugs.com

MARCH 7, 2024

new report of data from 2012 through 2021 finds a. THURSDAY, March 7, 2024 -- As more Americans pop over-the-counter melatonin to help them sleep, their young children are increasingly showing up in ERs after accidentally ingesting the supplements.A

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Science Daily: Pharmacology News

FEBRUARY 12, 2025

Surveys of college students conducted in 2012 and in 2022 found many similarities in their expectations about romantic relationships; however, they are now taking diverse paths through those relationships.

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Science Daily: Pharmacology News

SEPTEMBER 15, 2023

An antibody developed in 2012 to target only the toxic protein while leaving its healthy counterpart unscathed is currently undergoing clinical trials in human patients suffering from traumatic brain injury and Alzheimer's Disease. Experts pinpointed a toxic protein named cis P-tau in the blood and placenta of individuals with preeclampsia.

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Research Clinical Trials Trials Treatment 222

BioPharma Drive: Drug Pricing

FEBRUARY 10, 2025

Stuart Arbuckle, who’s been with Vertex since 2012, plans to retire from his role in July. His departure comes as Vertex launches two important new medicines.

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Science Daily: Pharmacology News

JUNE 8, 2023

gigatonnes (or billion metric tonnes) of carbon dioxide being released into the atmosphere on average every year over the last decade (2012-2021). The analysis also found that greenhouse gas emissions were 'at an all-time high', with human activity resulting in the equivalent of 54 (+/-5.3)

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Broad Institute

JANUARY 14, 2025

A long-awaited strategy Vallabh and Minikel have been studying prion disease since 2012, after Vallabhs mother passed away from a form of the disease called fatal familial insomnia and Vallabh found out that she had inherited the disease-causing mutation. This has the potential to be a really promising strategy.

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Disease DNA Protein Production Treatment 144

Drug Patent Watch

JULY 21, 2024

The Patent Trial and Appeal Board (PTAB) is a crucial component of the United States Patent and Trademark Office (USPTO), established in 2012 by the Leahy-Smith America Invents Act (AIA).

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Trials 105

Drug Hunter

MAY 21, 2023

One notable example comes from an HIV reverse transcriptase program led by Andy Peat, then at GSK, in 2012. This tour-de-force review from Yoshihiro Ishihara of Vividion Therapeutics and Debora Chiodi at Scripps compiles examples of chlorine atoms exerting outsized effects on SAR.

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Trials Drugs 144

ASPET

JUNE 5, 2012

The following manuscript was published as a Fast Forward article on February 29, 2012: Sullivan TJ, Dairaghi DJ, Krasinski A, Miao Z, Wang Y, Zhao BN, Baumgart T, Berahovich R, Ertl LS, Pennell A, Seitz L, Miao S, Ungashe S, Wei Z, Johnson D, Boring L, Tsou C-L, Charo IF, Bekker P, Schall TJ, and Jaen JC, Characterization of CCX140-B, an orally bioavailable (..)

Treatment 100

Treatment 100

Chemical Biology and Drug Design

JUNE 15, 2012

© 2012 John Wiley & Sons A/S Analogue 20l having pentyl and methyl substituents on tricycle showed promising activities against all pathogens. However, none was found active against HIV-1. Our study demonstrated that the tricyclic guanidine compounds provide new structral class for broad spectrum activity.

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NIOSH Science Blog: Drugs

JANUARY 10, 2024

Unintentional overdose from the nonmedical use of drugs resulted in 388 worker deaths in 2020, an increase of nearly 500 percent from 2012. The drug overdose epidemic is occurring in and impacting workplaces.

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Treatment Drugs 85

Drug Channels

DECEMBER 14, 2021

Since 2012, Drug Channels has examined commercial drug spending using the annual trend reports published by the largest PBMs. This week, I’m rerunning some popular posts while I prepare for this Friday’s live video webinar: Drug Channels Outlook 2022. Click here to see the original post and comments from July 2021.

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Pharmacy Drugs 98

Chemical Biology and Drug Design

APRIL 16, 2023

Among numerous vesicular systems, concept of transethosomes (TEs) introduced in 2012 are being tested for drug delivery to the dermis. The formulation scientist has developed a vesicular system to enhance the skin's absorption of bioactive substances. When transferosomes and ethosomes interact, TEs are produced.

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Drugs Compliance Research Marketing 100

SCIENMAG: Medicine & Health

MARCH 4, 2024

According to the National Health Insurance Service report covering the years from 2012 to 2022, there has been a 22.8% Degenerative arthritis is no longer exclusive to the elderly population. increase in the prevalence of degenerative arthritis among people in their 20s and 30s.

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Drug Target Review

APRIL 4, 2024

Nicholas continued to serve as CEO of NeuroSearch Sweden through 2012. Nicholas served as the CEO of IRLAB Sweden between 2012 and 2022 and for IRLAB therapeutics 2016-2022. In 2010 he was appointed Executive Vice President, Research at NeuroSearch. In 2013, Nicholas co-founded IRLAB Sweden.

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Disease Treatment Licensing Licensing 105

Perficient: Drug Development

AUGUST 15, 2023

Prior to Windows Server 2012, there were a couple of challenges when it comes to hosting secure sites: SSL Scalability: In a multi-tenanted environment, such as a shared hosting, there is a limitation as to how many secure sites can be hosted on Windows Server, resulting in a low site-density.

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Production 96

Agency IQ

JUNE 21, 2024

While this policy has been in place since 2012 for drug facilities, the same authority was only extended to FDA’s oversight of medical devices in 2017. The FDA has now finalized a revision to its guidance on the subject to provide more examples and incorporate device considerations.

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FDA Production Drugs 59

NIOSH Science Blog: Drugs

MARCH 27, 2024

Future Day was first celebrated worldwide on March 1, 2012 as a forward-looking reflection on all the possibilities the future holds for humanity.1 1 Just two years later, the global think tank Millennium Project helped expand the unofficial holiday into what is now recognized as World Futures Day.2

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International 65

Drug Target Review

OCTOBER 26, 2023

Alipogene tiparvovec and voretigene neparvovec-rzyl, two recombinant AAV-based gene therapy products, were approved by the European Medicines Agency (EMA) to treat lipoprotein lipase deficiency in 2012 2 and by the US Food and Drug Administration (FDA) to treat inherited retinal dystrophy in 2017, respectively. Nature 578 , 229-236 (2020).

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Drug Target Review

JANUARY 8, 2024

Shinya Yamanaka, who was awarded the Nobel prize in 2012, discovered that four transcription factors Oct4, Sox2, Klf4 and c-Myc could reprogram mature, differentiated cells back into stem cells. The epigenome drifts with age, leading to dysregulated gene expression.

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Science Disease FDA Approval Clinical Trials 145

Broad Institute

MARCH 8, 2024

Hung (2010 - 2011 awardee) James Bradner Jake Jaffe 2011 - 2012 Awardees Feng Zhang John Rinn Mitchell Guttman Anne Carpenter 2010 - 2011 Awardees Deborah T. Any questions about the Next Generation Awards program can be directed to Jacob Herman at jherman@broadinstitute.org.

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Research 52

The Pharma Data

JANUARY 15, 2021

15, 2021 — After publication of the 2012 guidelines defining vasectomy success as either azoospermia or rare nonmotile sperm, men undergoing vasectomy had a lower risk for requiring any repeat postvasectomy semen analysis, according to a study published online Jan. Professional. FRIDAY, Jan. 12 in Urology Practice. Tony Chen, M.D.,

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Research 52

Common Sense for Drug Policy Blog

AUGUST 9, 2023

Age-period-cohort decomposition found rapid increases in mortality since 2012 in men and women, with higher mortality risk in cohorts born after 1990.

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Drugs 52

Common Sense for Drug Policy Blog

OCTOBER 21, 2024

2012 ; Ruiz-Colón et al., 2012 ; Rodríguez et al., Xylazine in the Unregulated Drug Supply "Xylazine is a veterinary tranquilizer, which is not approved for human use in the United States, but is commonly used for sedating large animals ( Reyes et al., 2008 ; Torruella, 2011 ).

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Drugs 52

Broad Institute

JULY 13, 2023

Nature Methods, 2012]. Nature Methods, 2012]. Credit: Image set BBBC033v1 from Rivron et al. 2018, available from the Broad Bioimage Benchmark Collection [Ljosa et al., Human red blood cells imaged using differential interference contrast microscopy. Previous Next What inspired you all to create the guide?

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Molecular Biology Laboratories Research 98

Perficient: Drug Development

AUGUST 24, 2023

Understanding GraphQL: At its core, GraphQL is a query language and runtime for APIs that was developed by Facebook in 2012 and later open-sourced in 2015. In this comprehensive exploration, we’ll dive deep into the essence of GraphQL, its core principles, benefits, and real-world applications.

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Production 98

Common Sense for Drug Policy Blog

SEPTEMBER 8, 2023

When examining the historical trends of annual prevalence, we found a declining trend in reports of drug seizure from 7% in 2009 to 3% in 2012, while the prevalence between June 2019 and mid-March 2020 and between June and November of 2021 (4–5%) remained essentially the same as the annual prevalence in 2011–2012.

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Drugs Marketing 52

The Pharma Data

DECEMBER 3, 2020

3, 2020 — From 2012 to 2016, there was an increase in the percentage of Medicare beneficiaries on long-term dialysis who were aligned to an accountable care organization (ACO), with a reduction in spending seen for ACO-aligned beneficiaries, according to a study published online Nov. Professional. THURSDAY, Dec.

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Research Disease 52

LifeSciVC

APRIL 26, 2024

This has long been a feature of biopharma (see 2012 and 2016 posts on oncology and immune-oncology , respectively), but has been exacerbated by the creation of so many new companies. Third, with the proliferation of startups, we’ve seen incredible crowding in hyper-competitive therapeutic categories and modalities.

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DNA Science Marketing Clinical Trials 112

Drug Target Review

MARCH 4, 2025

Prior to founding Naia, Mark served as CEO of GenturaDx until its successful sale to Luminex Corporation in 2012. Prior to joining Health2047, Mark co-founded and served as COO of Naia Rare Diseases, a company focused on rare gastrointestinal disorders. GenturaDxs technology is the basis of Luminexs acclaimed Aries platform.

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Therapies Treatment Clinical Trials Science 52

Common Sense for Drug Policy Blog

DECEMBER 14, 2023

Notably, no major changes were apparent in the distribution of substances, on average, between 2012 and 2019, as reported in the literature. Specifically, the category of prescription drugs decreased in proportion, becoming the second smallest proportion of listings, from over 20% between 2012 and 2019 to under 5% between 2022 and 2023.

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Marketing Drugs Science 40

Drug Target Review

MARCH 3, 2025

” The advent of stem cell technology, especially the groundbreaking work of Shinya Yamanaka who won the Nobel Prize in 2012 for developing iPSCs, marked a pivotal moment. But it turned out I was completely wrong. It’s incredibly complex.”

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Disease Treatment Therapies Cell Biology 52

FDA Law Blog: Biosimilars

NOVEMBER 27, 2023

According to the government, these companies knew as early as 2012 that their dehumidifiers were defective, in that they could overheat and catch fire. (the “Gree Companies”), an appliance manufacturer and two of its subsidiaries that were involved in the manufacturing, marketing, and sale of dehumidifiers.

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Drug Target Review

NOVEMBER 1, 2023

2012 Feb 1;40(1):31–6. J Med Chem. 2016 Jun 23;59(12):5604–21. Gotoh M, Fujiwara Y, Yue J, et al. Controlling cancer through the autotaxin–lysophosphatidic acid receptor axis. Biochemical Society Transactions. Lee D, Suh DS, Lee SC, et al. Role of autotaxin in cancer stem cells. Cancer Metastasis Rev. 2018 Sep;37(2–3):509–18.

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Clinical Trials Trials Small Molecule Disease 134

Broad Institute

JANUARY 19, 2024

The Gal-Mor group had previously analyzed bacterial samples gathered from more than 48,000 people in Israel with salmonellosis between 1995 and 2012. percent of the cases became persistent infections that lingered for months to years.

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Immune Response Treatment Disease Research 119

FDA Law Blog: Biosimilars

MAY 13, 2024

Based on a review of premarket submissions made in 2012 through 2019, FDA identified 90 examples of 510(k)s, De Novos, HDEs, and PMAs approved/cleared which utilized RWE in support of regulatory decision-making. During this period the estimated total number of such submissions was approximately 26,121.

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Drug Channels

JULY 14, 2021

Since 2012, Drug Channels has examined commercial drug spending using the annual trend reports published by the largest PBMs. This year, we review 2020 data on commercial plan sponsor clients of CVS Health and Express Scripts along with two smaller PBMs—Navitus and WellDyne.

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Pharmacy Drugs 52