Drug Hunter

MAY 21, 2023

One notable example comes from an HIV reverse transcriptase program led by Andy Peat, then at GSK, in 2012. This tour-de-force review from Yoshihiro Ishihara of Vividion Therapeutics and Debora Chiodi at Scripps compiles examples of chlorine atoms exerting outsized effects on SAR.

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Trials Drugs 144

Drugs.com

SEPTEMBER 27, 2024

FRIDAY, September 27, 2024 -- In a sign that climate change may be fueling heat illnesses in kids, a new study reveals that such visits to two Texas children's emergency rooms spiked 170% between 2012 and 2023.Study Study leader Dr. Taylor Merritt, a.

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Hospitals 95

NIOSH Science Blog: Drugs

JANUARY 10, 2024

Unintentional overdose from the nonmedical use of drugs resulted in 388 worker deaths in 2020, an increase of nearly 500 percent from 2012. The drug overdose epidemic is occurring in and impacting workplaces.

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Treatment Drugs 90

ASPET

JUNE 5, 2012

The following manuscript was published as a Fast Forward article on February 29, 2012: Sullivan TJ, Dairaghi DJ, Krasinski A, Miao Z, Wang Y, Zhao BN, Baumgart T, Berahovich R, Ertl LS, Pennell A, Seitz L, Miao S, Ungashe S, Wei Z, Johnson D, Boring L, Tsou C-L, Charo IF, Bekker P, Schall TJ, and Jaen JC, Characterization of CCX140-B, an orally bioavailable (..)

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Treatment 100

Chemical Biology and Drug Design

JUNE 15, 2012

© 2012 John Wiley & Sons A/S Analogue 20l having pentyl and methyl substituents on tricycle showed promising activities against all pathogens. However, none was found active against HIV-1. Our study demonstrated that the tricyclic guanidine compounds provide new structral class for broad spectrum activity.

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Science Daily: Pharmacology News

SEPTEMBER 15, 2023

An antibody developed in 2012 to target only the toxic protein while leaving its healthy counterpart unscathed is currently undergoing clinical trials in human patients suffering from traumatic brain injury and Alzheimer's Disease. Experts pinpointed a toxic protein named cis P-tau in the blood and placenta of individuals with preeclampsia.

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Research Clinical Trials Trials Treatment 90

SCIENMAG: Medicine & Health

MARCH 4, 2024

According to the National Health Insurance Service report covering the years from 2012 to 2022, there has been a 22.8% Degenerative arthritis is no longer exclusive to the elderly population. increase in the prevalence of degenerative arthritis among people in their 20s and 30s.

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Chemical Biology and Drug Design

APRIL 16, 2023

Among numerous vesicular systems, concept of transethosomes (TEs) introduced in 2012 are being tested for drug delivery to the dermis. The formulation scientist has developed a vesicular system to enhance the skin's absorption of bioactive substances. When transferosomes and ethosomes interact, TEs are produced.

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Drugs Compliance Research Marketing 100

Science Daily: Pharmacology News

JUNE 8, 2023

gigatonnes (or billion metric tonnes) of carbon dioxide being released into the atmosphere on average every year over the last decade (2012-2021). The analysis also found that greenhouse gas emissions were 'at an all-time high', with human activity resulting in the equivalent of 54 (+/-5.3)

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NIOSH Science Blog: Drugs

MARCH 27, 2024

Future Day was first celebrated worldwide on March 1, 2012 as a forward-looking reflection on all the possibilities the future holds for humanity.1 1 Just two years later, the global think tank Millennium Project helped expand the unofficial holiday into what is now recognized as World Futures Day.2

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International 67

Drug Target Review

APRIL 4, 2024

Nicholas continued to serve as CEO of NeuroSearch Sweden through 2012. Nicholas served as the CEO of IRLAB Sweden between 2012 and 2022 and for IRLAB therapeutics 2016-2022. In 2010 he was appointed Executive Vice President, Research at NeuroSearch. In 2013, Nicholas co-founded IRLAB Sweden.

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Disease Treatment Licensing Licensing 105

Drug Channels

DECEMBER 14, 2021

Since 2012, Drug Channels has examined commercial drug spending using the annual trend reports published by the largest PBMs. This week, I’m rerunning some popular posts while I prepare for this Friday’s live video webinar: Drug Channels Outlook 2022. Click here to see the original post and comments from July 2021.

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Pharmacy Drugs 83

Perficient: Drug Development

AUGUST 15, 2023

Prior to Windows Server 2012, there were a couple of challenges when it comes to hosting secure sites: SSL Scalability: In a multi-tenanted environment, such as a shared hosting, there is a limitation as to how many secure sites can be hosted on Windows Server, resulting in a low site-density.

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Production 96

Drug Target Review

JANUARY 8, 2024

Shinya Yamanaka, who was awarded the Nobel prize in 2012, discovered that four transcription factors Oct4, Sox2, Klf4 and c-Myc could reprogram mature, differentiated cells back into stem cells. The epigenome drifts with age, leading to dysregulated gene expression.

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Science Disease FDA Approval Clinical Trials 145

Broad Institute

MARCH 8, 2024

Hung (2010 - 2011 awardee) James Bradner Jake Jaffe 2011 - 2012 Awardees Feng Zhang John Rinn Mitchell Guttman Anne Carpenter 2010 - 2011 Awardees Deborah T. Any questions about the Next Generation Awards program can be directed to Jacob Herman at jherman@broadinstitute.org.

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Research 52

Agency IQ

JUNE 21, 2024

While this policy has been in place since 2012 for drug facilities, the same authority was only extended to FDA’s oversight of medical devices in 2017. The FDA has now finalized a revision to its guidance on the subject to provide more examples and incorporate device considerations.

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FDA Production Drugs 59

Drug Target Review

OCTOBER 26, 2023

Alipogene tiparvovec and voretigene neparvovec-rzyl, two recombinant AAV-based gene therapy products, were approved by the European Medicines Agency (EMA) to treat lipoprotein lipase deficiency in 2012 2 and by the US Food and Drug Administration (FDA) to treat inherited retinal dystrophy in 2017, respectively. Nature 578 , 229-236 (2020).

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Engineering Virus Therapies Immune Response 105

The Pharma Data

JANUARY 15, 2021

15, 2021 — After publication of the 2012 guidelines defining vasectomy success as either azoospermia or rare nonmotile sperm, men undergoing vasectomy had a lower risk for requiring any repeat postvasectomy semen analysis, according to a study published online Jan. Professional. FRIDAY, Jan. 12 in Urology Practice. Tony Chen, M.D.,

Research 52

Research 52

Common Sense for Drug Policy Blog

AUGUST 9, 2023

Age-period-cohort decomposition found rapid increases in mortality since 2012 in men and women, with higher mortality risk in cohorts born after 1990.

Drugs 52

Drugs 52

Common Sense for Drug Policy Blog

OCTOBER 21, 2024

2012 ; Ruiz-Colón et al., 2012 ; Rodríguez et al., Xylazine in the Unregulated Drug Supply "Xylazine is a veterinary tranquilizer, which is not approved for human use in the United States, but is commonly used for sedating large animals ( Reyes et al., 2008 ; Torruella, 2011 ).

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Drugs 52

Broad Institute

JULY 13, 2023

Nature Methods, 2012]. Nature Methods, 2012]. Credit: Image set BBBC033v1 from Rivron et al. 2018, available from the Broad Bioimage Benchmark Collection [Ljosa et al., Human red blood cells imaged using differential interference contrast microscopy. Previous Next What inspired you all to create the guide?

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Molecular Biology Laboratories Research 98

Perficient: Drug Development

AUGUST 24, 2023

Understanding GraphQL: At its core, GraphQL is a query language and runtime for APIs that was developed by Facebook in 2012 and later open-sourced in 2015. In this comprehensive exploration, we’ll dive deep into the essence of GraphQL, its core principles, benefits, and real-world applications.

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Production 98

Agency IQ

SEPTEMBER 22, 2023

Regulatory background Biocides are regulated primarily by the Biocidal Products Regulation (BPR) (528/2012/EU). It appears the issue is largely the result of unclear labeling for biocidal disinfectants, an aspect French regulators may flag in future market authorization evaluations for these products.

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Regulations Production Marketing 59

Covalent Modifiers

NOVEMBER 18, 2024

In this review, we introduce the biological functions of IDH, describe the tumorigenesis mechanisms of IDH variants, and review the structure-based drug discovery of clinical inhibitors during 2012-2024. We also find successful applications of covalent strategy in the development of irreversible IDH inhibitors.

Drugs 59

Drugs Research 59

Broad Institute

JANUARY 19, 2024

The Gal-Mor group had previously analyzed bacterial samples gathered from more than 48,000 people in Israel with salmonellosis between 1995 and 2012. percent of the cases became persistent infections that lingered for months to years.

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Immune Response Treatment Disease Research 119

The Pharma Data

DECEMBER 3, 2020

3, 2020 — From 2012 to 2016, there was an increase in the percentage of Medicare beneficiaries on long-term dialysis who were aligned to an accountable care organization (ACO), with a reduction in spending seen for ACO-aligned beneficiaries, according to a study published online Nov. Professional. THURSDAY, Dec.

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Research Disease 52

Common Sense for Drug Policy Blog

DECEMBER 14, 2023

Notably, no major changes were apparent in the distribution of substances, on average, between 2012 and 2019, as reported in the literature. Specifically, the category of prescription drugs decreased in proportion, becoming the second smallest proportion of listings, from over 20% between 2012 and 2019 to under 5% between 2022 and 2023.

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Marketing Drugs Science 40

LifeSciVC

APRIL 26, 2024

This has long been a feature of biopharma (see 2012 and 2016 posts on oncology and immune-oncology , respectively), but has been exacerbated by the creation of so many new companies. Third, with the proliferation of startups, we’ve seen incredible crowding in hyper-competitive therapeutic categories and modalities.

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DNA Science Marketing Clinical Trials 107

Agency IQ

SEPTEMBER 1, 2023

Regulatory background The Prior Informed Consent Regulation (EU) 649/2012 (PIC) is the main act on the export and import of hazardous chemicals between the European Union and third countries.

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Regulations International 52

FDA Law Blog: Biosimilars

NOVEMBER 27, 2023

According to the government, these companies knew as early as 2012 that their dehumidifiers were defective, in that they could overheat and catch fire. (the “Gree Companies”), an appliance manufacturer and two of its subsidiaries that were involved in the manufacturing, marketing, and sale of dehumidifiers.

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Production Government Trials Marketing 104

Drug Target Review

NOVEMBER 1, 2023

2012 Feb 1;40(1):31–6. J Med Chem. 2016 Jun 23;59(12):5604–21. Gotoh M, Fujiwara Y, Yue J, et al. Controlling cancer through the autotaxin–lysophosphatidic acid receptor axis. Biochemical Society Transactions. Lee D, Suh DS, Lee SC, et al. Role of autotaxin in cancer stem cells. Cancer Metastasis Rev. 2018 Sep;37(2–3):509–18.

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Clinical Trials Small Molecule Trials Disease 134

Agency IQ

JANUARY 26, 2024

In 2012, the EPA issued its first official Scientific Integrity Policy (2012 SIP). The agency also appointed its first Scientific Integrity Official (SIO) in the wake of the 2012 SIP. The policy will replace the 2012 SIP and reaffirm the role of the EPA’s SIO and deputy SIOs around the agency.

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Science Government Production International 40

FDA Law Blog: Biosimilars

MAY 13, 2024

Based on a review of premarket submissions made in 2012 through 2019, FDA identified 90 examples of 510(k)s, De Novos, HDEs, and PMAs approved/cleared which utilized RWE in support of regulatory decision-making. During this period the estimated total number of such submissions was approximately 26,121.

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FDA Production Trials Pharmacy 111

Drug Channels

JULY 14, 2021

Since 2012, Drug Channels has examined commercial drug spending using the annual trend reports published by the largest PBMs. This year, we review 2020 data on commercial plan sponsor clients of CVS Health and Express Scripts along with two smaller PBMs—Navitus and WellDyne.

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Pharmacy Drugs 52

The Pharma Data

JANUARY 24, 2021

Established in 2012, Samsung Bioepis has rapidly grown to have five biologic products in immunology and oncology with more than 215,000 patients treated with the company’s immunology products in Europe alone. Established in 2012, Samsung Bioepis is a biopharmaceutical company committed to realizing healthcare that is accessible to everyone.

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Laboratories Biosimilars Production 52

Policy Prescription

JANUARY 31, 2022

Despite the law requiring the reporting of suspicious orders, the Gazette-Mail reported that between 2001-2012 the board received only two reports , both from Cardinal Health. In West Virginia, by 2012 big wholesaler pharmacies were under investigation by the state attorney general: and then the suspicious order reports began to come in.

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Pharmacy Regulations Doctors Drugs 52

The Pharma Data

SEPTEMBER 27, 2021

The number of dispensed prescriptions for opioid analgesics has been steadily declining from a peak of 84 prescriptions per 100 residents in 2012 to 43 prescriptions per 100 residents in 2020. A wide sort of interventions intended to scale back inappropriate or unnecessary prescribing, including prescriber education initiatives.

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FDA Treatment Research Drugs 52