Cancer immunotherapy: GDF-15’s role in Anti-PD-1 resistance
Drug Target Review
AUGUST 24, 2023
Neutralising GDF-15 with CatalYm’s anti-GDF-15 antibody visugromab was shown to reverse its inhibitory effects and to re-sensitise tumours to anti-PD-1 treatment, achieving commensurate survival benefit of anti-GDF-15-anti-PD-1 combination therapy in vivo. Current Opinion in Cell Biology. 2012 Feb 1;24(1):107-15.
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