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Cancer immunotherapy: GDF-15’s role in Anti-PD-1 resistance

Drug Target Review

Neutralising GDF-15 with CatalYm’s anti-GDF-15 antibody visugromab was shown to reverse its inhibitory effects and to re-sensitise tumours to anti-PD-1 treatment, achieving commensurate survival benefit of anti-GDF-15-anti-PD-1 combination therapy in vivo. Current Opinion in Cell Biology. 2012 Feb 1;24(1):107-15.

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Precision Medicine in the Genomic Era

DrugBank

Their use, as well as their integration into other types of data, has enabled the development of more precise therapies. 14 As an unbiased method for genetic variant detection, GWAS holds the promise of identifying new genes and gene regulation mechanisms underlying a variety of conditions, including complex diseases. Genomics Hum.

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The Codon Guide to Synthetic Biology

Codon

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

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The Codon Guide to Synthetic Biology

Codon

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

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