Codon

AUGUST 26, 2024

Credit: OpenStax College The innate immune system has been evolutionarily successful for three reasons: its tools target the most fundamental properties of viruses , act as prophylactics —meaning they prevent diseases, rather than treat them—and are widespread. Other approaches could allow for less frequent dosing.

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RNA Virus DNA Vaccine 86

The Pharma Data

SEPTEMBER 3, 2020

The technology could one day prevent parents from passing on heritable diseases to children, but the committee says much more research is needed. Gene-editing could potentially help avoid a range of heritable diseases by deleting or changing troublesome coding in embryos.

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DNA International Science Disease 52

PLOS: DNA Science

OCTOBER 12, 2023

In the final chapter of my 2012 book The Forever Fix: Gene Therapy and the Boy Who Saved It , I predicted that the technology would soon expand well beyond the rare disease world. Gene therapy clearly hasn’t had a major impact on health care, offering extremely expensive treatments for a few individuals with rare diseases.

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Therapies Immune Response DNA Virus 69

Drug Target Review

OCTOBER 4, 2023

Antibody-drug conjugates (ADCs) have been a groundbreaking approach to cancer treatment with their ability to deliver cytotoxic drugs directly to diseased cells while sparing healthy tissues. 2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads. Florian S, Mitchison TJ.

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Small Molecule Drugs Immune Response Targeted Protein Degradation 126

DrugBank

NOVEMBER 4, 2024

This decline in R&D is attributed to scientific challenges associated with identifying new antibiotic targets and the relatively low return on investment compared to other therapeutic areas like oncology or rare diseases.    Pharmaceutical companies are, therefore, exploring innovative approaches. For instance, the U.S.

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Pharmaceutical Companies Government Pharmaceuticals DNA 72

PLOS: DNA Science

SEPTEMBER 21, 2023

In addition to rare genetic diseases, talks at the Festival will address Crohn’s disease, rheumatoid arthritis, polycystic ovarian syndrome, and neurological disease and cancers. See Socially Responsible Genetic Research with Descendants of the First Australians from 2012.) They shared the Nobel Prize in 2020.

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DNA Science Medical Schools Government 52

Codon

MARCH 19, 2024

Most people die from cardiovascular disease, while others succumb to Alzheimer’s and cancer. Take cardiovascular disease as an example. However, this approach is imperfect because it only addresses one manifestation of the disease, rather than its root. José Luis Ricón ( Nintil ) writes about aging for Issue 01.

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DNA Small Molecule Regulations Laboratories 55

DrugBank

JUNE 27, 2023

Out of the millions of genetic variants present in human populations, GWAS are designed to uncover those associated with specific traits or diseases. 9 Polygenic diseases are much more common, and thousands of genetic variants with very small effects could impact their phenotype.

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Disease Treatment Drugs Clinical Trials 88

Agency IQ

APRIL 19, 2024

FDA advisors endorse minimal residual disease (MRD) as accelerated approval endpoint for multiple myeloma Last week, FDA’s Oncologic Drugs Advisory Committee (ODAC) voted unanimously in favor of using minimal residual disease (MRD) as an accelerated approval endpoint for multiple myeloma.

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FDA Disease Trials Clinical Trials 40

Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

DNA 52

DNA Engineering Therapies RNA 52

Agency IQ

MARCH 29, 2024

FDA’s oncology advisory committee to consider MRD as a multiple myeloma endpoint Yesterday, the FDA announced that its Oncologic Drugs Advisory Committee would weigh in on the potential use of minimal residual disease (MRD) as an endpoint in multiple myeloma clinical trials. immune cells and other blood cell types) lack.

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FDA Clinical Trials Treatment Trials 40

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. Experiments around using genetically modified organisms to produce proteins have been taking place since the earliest days of the recombinant DNA revolution.

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Engineering Vaccine Production RNA 84

Codon

MARCH 7, 2024

With a flourish of his gloved hand and the aplomb of an evangelical pastor, Wilde continues: “As you are no doubt aware, the Vector Zoo commemorates humanity’s valiant efforts to eradicate zoonotic and vector-borne diseases. Humanity's long battle against malaria has shaped the human genome more than any other disease.

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Vaccine Disease Doctors DNA 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

New Drug Approvals

JANUARY 9, 2024

The present invention is directed to methods of preparation of compound of formula (I) that is useful for inhibiting Cyclin-dependent kinase 7 (CDK7) and for treating diseases or disorders mediated thereby. May 30; 31(11): 2498-510, 2012). CDK7 also plays a role in transcription and possibly in DNA repair. Mar 23;25(6):839-50.

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Production DNA RNA Regulations 62

PLOS: DNA Science

MARCH 16, 2023

” That means the genome of the doomed fetus-within-a-fetus had lots of copies of certain short DNA sequences that aren’t in the parents’ genomes (“ de novo ” means new). In addition to their roles in development, DNA repeats are used in DNA profiling and are behind a class of inherited diseases.

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DNA Disease Science Doctors 52

PLOS: DNA Science

JULY 11, 2024

In the classic film Jurassic Park (JP) from 1993, disasters unfurl at a theme park populated with dinosaurs cloned from reptile DNA in mosquitoes fossilized in amber, with modern frog DNA filling in gaps. The animals were cloned from DNA in bits of preserved ear bones, and doctored a bit. percent of our DNA sequence with chimps?

DNA 52

DNA Science Doctors Engineering 52

The Pharma Data

MARCH 22, 2022

Consistent results were observed at 200 days of follow-up with respect to CMV reactivation, clinically significant CMV infection, and CMV disease. Real-World Outcomes for Primary Prophylaxis of CMV Infection and Disease Using PREVYMIS. See additional results below. About PREVYMIS (letermovir).

Disease 52

Disease Virus DNA Therapies 52

The Pharma Data

OCTOBER 21, 2020

These findings were presented today at the 2020 Infectious Diseases Society of America (IDSA) IDWeek. INSTIs, like cabotegravir, inhibit HIV replication by preventing the viral DNA from integrating into the genetic material of human immune cells (T-cells). Shionogi joined in October 2012. Kimberly Smith, M.D.,

Clinical Development 52

Clinical Development Therapies Clinical Trials Treatment 52

PLOS: DNA Science

DECEMBER 21, 2023

A few weeks ago, I noticed a surprising metric when posting my weekly DNA Science blog – at year’s end, I’d hit #500! The Birth of DNA Science When St. Martin’s Press was about to publish my book about gene therapy in 2012, my agent urged me to start blogging. We renamed it DNA Science.

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DNA Vaccine Science Therapies 105

Molecule Blog

OCTOBER 1, 2020

This changed with advancements in antibiotics and the ability to combat communicable diseases, which led to a more than 50% increase in human life expectancy since 1900. Today, age-related pathologies such as cancer, cardiovascular disease, and neurodegeneration are among the leading causes of mortality and disability.

Clinical Trials 52

Clinical Trials Therapies Disease Trials 52

Codon

AUGUST 10, 2023

Drug Discovery Today: Disease Models (2008). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Artificial Life (2018). PNAS (2013).

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DNA Cell Biology Molecular Biology Engineering 91

Codon

AUGUST 10, 2023

Drug Discovery Today: Disease Models (2008). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Artificial Life (2018). PNAS (2013).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52