The Pharma Data

OCTOBER 21, 2020

In the midst of the global pandemic, the analysis found no antiretroviral therapy interruptions across the entirety of the ongoing clinical development programme for long-acting cabotegravir and rilpivirine. These findings were presented today at the 2020 Infectious Diseases Society of America (IDSA) IDWeek. Kimberly Smith, M.D.,

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Drug Discovery World

JULY 18, 2023

Rolf Turk , Senior Manager, Genomics Medicine at Integrated DNA Technologies, examines how CRISPR is being used to enhance cancer therapies. Years of development and fast-paced research have continued to unlock its potential, expanding how CRISPR can be used to treat, detect, and prevent common diseases such as cancer and Covid-19.

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Disease DNA RNA Therapies 246

Codon

JUNE 11, 2024

Biologists use nanopores for everything from diagnosing diseases and monitoring changes within rainforest ecosystems to discovering proteins from microbes frozen in Icelandic glaciers. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast. An Oxford Nanopore device.

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DNA Engineering RNA Small Molecule 73

The Pharma Data

MARCH 22, 2022

Consistent results were observed at 200 days of follow-up with respect to CMV reactivation, clinically significant CMV infection, and CMV disease. Real-World Outcomes for Primary Prophylaxis of CMV Infection and Disease Using PREVYMIS. See additional results below. About PREVYMIS (letermovir).

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Disease Virus DNA Hospitals 52

PLOS: DNA Science

JULY 11, 2024

In the classic film Jurassic Park (JP) from 1993, disasters unfurl at a theme park populated with dinosaurs cloned from reptile DNA in mosquitoes fossilized in amber, with modern frog DNA filling in gaps. The animals were cloned from DNA in bits of preserved ear bones, and doctored a bit. percent of our DNA sequence with chimps?

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DNA Science Doctors Engineering 52

Agency IQ

APRIL 19, 2024

FDA advisors endorse minimal residual disease (MRD) as accelerated approval endpoint for multiple myeloma Last week, FDA’s Oncologic Drugs Advisory Committee (ODAC) voted unanimously in favor of using minimal residual disease (MRD) as an accelerated approval endpoint for multiple myeloma.

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Drug Target Review

AUGUST 9, 2023

Published on bit.bio’s website, this article authored by Dr Tony Oosterveen dives into the close relationship between FTD and ALS with a focus on mechanisms underlying the neuropathology of both diseases. ALS is the most common motor neuron disease and is estimated to affect more than 80,000 people worldwide.

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RNA Regulations Disease DNA 98

Drug Target Review

OCTOBER 4, 2023

Antibody-drug conjugates (ADCs) have been a groundbreaking approach to cancer treatment with their ability to deliver cytotoxic drugs directly to diseased cells while sparing healthy tissues. 2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads.

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Small Molecule Drugs Immune Response Targeted Protein Degradation 126

Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

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DNA Engineering RNA Therapies 52

Codon

MARCH 19, 2024

Most people die from cardiovascular disease, while others succumb to Alzheimer’s and cancer. Take cardiovascular disease as an example. However, this approach is imperfect because it only addresses one manifestation of the disease, rather than its root. José Luis Ricón ( Nintil ) writes about aging for Issue 01.

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DNA Small Molecule Regulations Laboratories 56

DrugBank

JUNE 27, 2023

Out of the millions of genetic variants present in human populations, GWAS are designed to uncover those associated with specific traits or diseases. Their use, as well as their integration into other types of data, has enabled the development of more precise therapies. by altering its accessibility to transcriptional machinery).

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Disease Treatment Drugs International 87

Drug Discovery World

OCTOBER 21, 2022

As we gain deeper understanding of normal biological processes as well as diseases, researchers and clinicians are increasingly seeking to analyse as many cellular parameters as possible to unravel their complexity. Take, for example, its use for CD4 T cell counting to facilitate HIV monitoring. Future directions . Nolan JP and Condello D.

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Drugs Research Immune Response Production 130

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. Experiments around using genetically modified organisms to produce proteins have been taking place since the earliest days of the recombinant DNA revolution.

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Engineering Vaccine Production RNA 85

PLOS: DNA Science

DECEMBER 21, 2023

A few weeks ago, I noticed a surprising metric when posting my weekly DNA Science blog – at year’s end, I’d hit #500! The Birth of DNA Science When St. Martin’s Press was about to publish my book about gene therapy in 2012, my agent urged me to start blogging. We renamed it DNA Science.

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DNA Vaccine Science Therapies 105

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide.

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DNA Therapies Engineering Clinical Trials 52

Molecule Blog

OCTOBER 1, 2020

This changed with advancements in antibiotics and the ability to combat communicable diseases, which led to a more than 50% increase in human life expectancy since 1900. Today, age-related pathologies such as cancer, cardiovascular disease, and neurodegeneration are among the leading causes of mortality and disability.

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Clinical Trials Therapies Disease Trials 52

Codon

AUGUST 10, 2023

Drug Discovery Today: Disease Models (2008). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Artificial Life (2018). PNAS (2013).

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DNA Cell Biology Molecular Biology Engineering 91

Codon

AUGUST 10, 2023

Drug Discovery Today: Disease Models (2008). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Artificial Life (2018). PNAS (2013).

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DNA Cell Biology Engineering Molecular Biology 52