The Pharma Data

SEPTEMBER 3, 2020

One example of current technology is CRISPR, a biological system for altering DNA discovered in 2012. CRISPR scans the genome looking for the right location, and then uses “molecular scissors” to snip through the faulty DNA. While effective in the lab, the process is less than perfect and can cut out too much DNA.

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DNA International Science Disease 52

Codon

AUGUST 26, 2024

In 2012, a research group at MIT isolated the major components of mucus from pig stomachs (“porcine gastric mucins”) and tested its ability to inhibit infections caused by human papillomavirus, influenza virus, and Merkel cell polyomavirus. Other approaches could allow for less frequent dosing.

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RNA Virus DNA Vaccine 87

Drug Target Review

NOVEMBER 6, 2023

At AstraZeneca and beyond we are exploring the use of cell-free DNA (cfDNA) methods to assess minimal residual disease as a possible intermediate endpoint across several disease types. 2012);12(4):237-251. Front Pharmacol. 2018;9:1300. Published 2018 Nov 13. doi:10.3389/fphar.2018.01300 2018.01300 Vanneman M, Dranoff G.

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Small Molecule Therapies Treatment Disease 111

PLOS: DNA Science

OCTOBER 12, 2023

In the final chapter of my 2012 book The Forever Fix: Gene Therapy and the Boy Who Saved It , I predicted that the technology would soon expand well beyond the rare disease world. million DNA bases. The DMD gene therapy delivers a shortened version of the dystrophin gene, just 4,558 DNA bases. appeared first on DNA Science.

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Drug Target Review

OCTOBER 4, 2023

2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads. DNA damaging agent-based antibody-drug conjugates for cancer therapy. While highly effective against proliferating tumour cells, ADCs with antimitotic payloads typically struggled against slower-growing cancer types.

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PLOS: DNA Science

SEPTEMBER 21, 2023

(See Socially Responsible Genetic Research with Descendants of the First Australians from 2012.) What steps should researchers take when attempting to acquire DNA samples from modern descendants? The women were wonderfully down-to-earth, stunned at all the attention since they published their key paper in 2012.

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Codon

JULY 17, 2024

Backyard astronomers discovered 42 new planets in 2012 , hobbyist paleontologists discovered the world’s largest dinosaur footprint near the Yorkshire coast in 2021, and Sebastian himself open-sourced protocols that make it easier for scientists to engineer plants. I use it to transform—or push DNA into—plant cells.

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Laboratories Engineering Molecular Biology Science 86

DrugBank

NOVEMBER 4, 2024

Their joint efforts have led to the development of gepotidacin , a novel first-in-class antibiotic that inhibits the bacterial enzymes topoisomerase II and DNA gyrase, which are essential for DNA replication and repair. For instance, the U.S.

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Codon

MARCH 19, 2024

Most cells (excluding T-cells and B cells after V(D)J recombination) in our body contain the same DNA but appear and behave in distinct ways: A neuron looks and acts very differently from a hepatocyte. While DNA is relatively stable , the epigenome is not; it has to orchestrate changes in cell state, cell type, and more.

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DNA Small Molecule Regulations Laboratories 54

Drug Target Review

AUGUST 9, 2023

The specific proteins found in these aggregates can vary, but approximately 95 percent of ALS patients and 50 percent of FTD patients develop aggregates containing the TDP-43 protein (short for tar DNA binding protein 43). 14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts.

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RNA Regulations Disease DNA 98

Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

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DNA Engineering Therapies RNA 52

The Pharma Data

NOVEMBER 22, 2021

Important discoveries have included Francis Crick and James Watson’s DNA advance in 1953, and Professor Sir John Gurdon’s work on stem cells in 2012. Over the once century, roughly 50 Nobel Prize winners in chemistry and physiology or drug have been associated with Cambridge. region in the US, and Gothenburg in Sweden.

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Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

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DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

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DNA Therapies Engineering Clinical Trials 52

Codon

DECEMBER 17, 2023

Recombinant DNA technologies were invented in the 1970s. CRISPR gene-editing was invented in 2012 and applied to human embryos soon after. Gene-editing methods, polymerase chain reaction, and the first human drug made from engineered microbes all debuted in the 1980s. A first draft of the human genome was completed in 2003.

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Engineering Molecular Biology Doctors DNA 52

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. Experiments around using genetically modified organisms to produce proteins have been taking place since the earliest days of the recombinant DNA revolution.

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Engineering Vaccine Production RNA 79

PLOS: DNA Science

OCTOBER 24, 2024

It wasn’t until 2012 that a physician who was an expert in the comparative anatomy of limbs of different animals, Stefan Mundlos, saw a patient who had odd-looking and stiff elbows, and unusual muscles and tendons. The post The Dangers of “Do Your Own Research” and “Believe in Science” appeared first on DNA Science.

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Agency IQ

OCTOBER 12, 2023

In particular, they discussed the potential for genotoxicity, or the potential to damage human DNA, and developmental neurotoxicity, or the negative effect on the developing human nervous system. These experts concluded that there were real concerns regarding the human health risk of chlorpyrifos and CHP-methyl.

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Regulations Animal Testing Government Production 40

DrugBank

JUNE 27, 2023

In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g., 13 , 1–27 (2012). Coding mutations have a more direct effect through direct alteration of a gene product. by altering its accessibility to transcriptional machinery). & Barbadilla, A.

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Agency IQ

MARCH 29, 2024

Between 2012 and 2018, the five-year relative survival rate for patients with MM was 57%. Treatment for this cancer may be lifelong, with patient and disease characteristics guiding the course of treatment.

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FDA Clinical Trials Treatment Trials 40

New Drug Approvals

JANUARY 9, 2024

May 30; 31(11): 2498-510, 2012). CDK7 also plays a role in transcription and possibly in DNA repair. The trimeric Cak complex CDK7/CyclinH/MATl is also a component of TFIIH, the general transcription/DNA repair factor IIH (Morgan, DO., Mar 23;25(6):839-50. 2007; Ganuza et al., Cancer Res. 8, 3527-3538, 2002).

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Codon

MARCH 7, 2024

Anopheles stephensi , the primary mosquito vector in Southeast Asia, showed up in Northern Africa in 2012. We have taken the liberty of overlaying our own genome next to theirs, and you can see for yourself that even when DNA insertions and deletions are taken into account, humans and chimpanzees still share 96 percent sequence identity.

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Vaccine Disease Doctors DNA 52

Agency IQ

APRIL 19, 2024

Although therapeutics have contributed to improvements in survival, the five-year relative survival rate for patients with MM was just 57% between 2012 and 2018. Despite the availability of treatments, there is still significant unmet need for patients with MM.

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FDA Disease Trials Clinical Trials 40

PLOS: DNA Science

MARCH 16, 2023

” That means the genome of the doomed fetus-within-a-fetus had lots of copies of certain short DNA sequences that aren’t in the parents’ genomes (“ de novo ” means new). In addition to their roles in development, DNA repeats are used in DNA profiling and are behind a class of inherited diseases.

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DNA Disease Science Doctors 52

PLOS: DNA Science

JULY 11, 2024

In the classic film Jurassic Park (JP) from 1993, disasters unfurl at a theme park populated with dinosaurs cloned from reptile DNA in mosquitoes fossilized in amber, with modern frog DNA filling in gaps. The animals were cloned from DNA in bits of preserved ear bones, and doctored a bit. percent of our DNA sequence with chimps?

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DNA Science Doctors Engineering 52

Agency IQ

MARCH 29, 2024

The EPA is also proposing our response to a petition regarding the continued validity of EPA’s 2012 determination (and September 2017 affirmation) that participation in the Cross State Air Pollution Rule (CSAPR) meets the Regional Haze Rule’s criteria for an alternative to the application of source-specific BART.

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Regulations Compliance Production Government 40

The Pharma Data

OCTOBER 21, 2020

INSTIs, like cabotegravir, inhibit HIV replication by preventing the viral DNA from integrating into the genetic material of human immune cells (T-cells). Shionogi joined in October 2012. This step is essential in the HIV replication cycle and is also responsible for establishing chronic infection.

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Clinical Development Therapies Clinical Trials Treatment 52

The Pharma Data

MARCH 22, 2022

PREVYMIS is fully active against viral populations with substitutions conferring resistance to CMV DNA polymerase inhibitors. These DNA polymerase inhibitors are fully active against viral populations with substitutions conferring resistance to PREVYMIS. PREVYMIS has no activity against other viruses.

Disease 52

Disease Virus DNA Therapies 52

PLOS: DNA Science

DECEMBER 21, 2023

A few weeks ago, I noticed a surprising metric when posting my weekly DNA Science blog – at year’s end, I’d hit #500! The Birth of DNA Science When St. Martin’s Press was about to publish my book about gene therapy in 2012, my agent urged me to start blogging. We renamed it DNA Science.

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DNA Vaccine Science Therapies 105

Molecule Blog

OCTOBER 1, 2020

It is now known that specific cellular pathways likely underpin the aging process (Burgess, 2012). The development of a drug therapy that extends life is summarised by much of the ongoing work in senolytics , telomeres, stem cells, mitochondria, DNA damage and repair, and gene editing.

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Clinical Trials Therapies Disease Trials 52

Codon

JANUARY 2, 2025

Embracing the book’s technology theme, we did something very special: With the help of three companies — CATALOG, Imagene, and Plasmidsaurus — we’ve encoded a complete copy of the book into DNA, thus merging bits with atoms. We’ve made 1,000 DNA capsules in total.

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DNA Laboratories Packaging Vaccine 108

Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

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DNA Cell Biology Molecular Biology Engineering 94

Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

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DNA Cell Biology Engineering Molecular Biology 52