Agency IQ

MARCH 29, 2024

Patients frequently receive up to four therapies at once and go through multiple prolonged courses of treatment to keep recurrence and progression at bay. Between 2012 and 2018, the five-year relative survival rate for patients with MM was 57%. More recently, CAR T cell therapies have been approved to treat advanced multiple myeloma.

FDA 40

FDA Clinical Trials Trials Treatment 40

Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

DNA 104

DNA Engineering RNA Small Molecule 104

Drug Discovery World

JULY 18, 2023

Rolf Turk , Senior Manager, Genomics Medicine at Integrated DNA Technologies, examines how CRISPR is being used to enhance cancer therapies. CRISPR also addresses another limitation in CAR T therapies related to the insufficient quantity and poor quality of autologous T cells.

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Disease DNA RNA Therapies 246

Drug Target Review

OCTOBER 4, 2023

2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads. Dual payload ADCs As effective as therapies have been in treating solid and haematological cancers, tumour heterogeneity and resistance remain major clinical challenges. Fu Y, Ho M. 1 , 33–43 (2018).

Small Molecule 126

Small Molecule Drugs Immune Response Targeted Protein Degradation 126

The Pharma Data

MARCH 22, 2022

These studies involved patients predominantly in the United States, Italy, and Japan and employed a range of timepoints for initiation of PREVYMIS post-transplant (0 – 42 days) and duration of therapy (79 – 191 days). About PREVYMIS (letermovir). PREVYMIS has no activity against other viruses.

Disease 52

Disease Virus DNA Hospitals 52

Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

DNA 52

DNA Engineering RNA Therapies 52

Codon

MARCH 19, 2024

Most cells (excluding T-cells and B cells after V(D)J recombination) in our body contain the same DNA but appear and behave in distinct ways: A neuron looks and acts very differently from a hepatocyte. While DNA is relatively stable , the epigenome is not; it has to orchestrate changes in cell state, cell type, and more.

DNA 59

DNA Small Molecule Regulations Laboratories 59

Codon

DECEMBER 17, 2023

Recombinant DNA technologies were invented in the 1970s. CRISPR gene-editing was invented in 2012 and applied to human embryos soon after. At least six CAR-T cancer therapies have now garnered F.D.A. Gene-editing methods, polymerase chain reaction, and the first human drug made from engineered microbes all debuted in the 1980s.

Engineering 52

Engineering Molecular Biology Doctors DNA 52

Drug Target Review

AUGUST 9, 2023

The specific proteins found in these aggregates can vary, but approximately 95 percent of ALS patients and 50 percent of FTD patients develop aggregates containing the TDP-43 protein (short for tar DNA binding protein 43). 14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts.

RNA 98

RNA Regulations Disease DNA 98

Agency IQ

APRIL 19, 2024

Patients frequently receive up to four therapies at once and go through multiple prolonged courses of treatment to keep recurrence and progression at bay. Commonly combined treatment options include antineoplastics (chemotherapies), radiation therapy, corticosteroids, immunomodulators, proteasome inhibitors, and monoclonal antibodies.

FDA 40

FDA Disease Trials Clinical Trials 40

Drug Discovery World

OCTOBER 21, 2022

DNA-based dyes, amine-reactive, fixable dyes) as oversaturated staining can falsely lead to over-exclusion of live cells from analysis. . He joined BioLegend in 2012, contributing in multiple roles and is now Director of Strategic Marketing responsible for Product Management, Technical Services, and Scientific Applications. .

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Drugs Research Immune Response Production 130

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. Experiments around using genetically modified organisms to produce proteins have been taking place since the earliest days of the recombinant DNA revolution.

Engineering 87

Engineering Vaccine Production RNA 87

DrugBank

JUNE 27, 2023

Their use, as well as their integration into other types of data, has enabled the development of more precise therapies. In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g., 13 , 1–27 (2012). & Barbadilla, A.  Olson, M.

Disease 89

Disease Treatment Drugs DNA 89

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide.

DNA 52

DNA Therapies Engineering Clinical Trials 52

PLOS: DNA Science

DECEMBER 21, 2023

A few weeks ago, I noticed a surprising metric when posting my weekly DNA Science blog – at year’s end, I’d hit #500! The Birth of DNA Science When St. Martin’s Press was about to publish my book about gene therapy in 2012, my agent urged me to start blogging. We renamed it DNA Science.

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DNA Vaccine Science Therapies 91

Molecule Blog

OCTOBER 1, 2020

It is now known that specific cellular pathways likely underpin the aging process (Burgess, 2012). Some of the brightest minds in the field see these therapies on the horizon — SENS’ Dr. Aubrey de Grey believes one will be available within 20 years. Indication expansion is the use of approved drugs in Longevity applications.

Clinical Trials 52

Clinical Trials Therapies Disease Trials 52

Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52