PLOS: DNA Science

JUNE 27, 2024

After all, they can reproduce even under radiation levels 1,000 times that which would kill a human, possessing admirable DNA repair skills. But since 2012, the gene editing tool CRISPR has introduced a specificity to removing a gene to see what it does. And that’s what the work described in the new paper in PLoS Genetics does.

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DNA Vaccine Research International 98

Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Caruthers was announced as the winner in June for his development, in 1981, of an efficient, automated technology for synthesizing DNA.

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DNA RNA Science Protein Expression 52

Codon

AUGUST 26, 2024

He also explains how they could be used to combat pandemics on “day zero,” well before vaccines are developed. After the outbreak ended, it took another three years for the first Ebola vaccine by Merck to be approved. Timelines for vaccine development are shrinking, but can it move even faster?

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RNA Virus DNA Vaccine 86

Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. Molecular Therapy 20 , 1831-1832 (2012). 1 Adeno-associated virus (AAV) vectors are the leading platform for in vivo gene delivery for the treatment of various human diseases. Ylä-Herttuala S.

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Engineering Virus Therapies Immune Response 105

Drug Target Review

OCTOBER 4, 2023

2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads. Throughout his career he has applied innovative solutions for the design, manufacture and clinical evaluation of novel products including vaccines, biologics, and small molecules in multiple therapeutic areas.

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Small Molecule Drugs Immune Response Targeted Protein Degradation 126

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. MenAfriVac is a meningococcal vaccine that remains active, without refrigeration, for up to four days and has significantly boosted vaccine coverage in parts of sub-Saharan Africa.

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Engineering Vaccine Production RNA 84

DrugBank

NOVEMBER 4, 2024

Their joint efforts have led to the development of gepotidacin , a novel first-in-class antibiotic that inhibits the bacterial enzymes topoisomerase II and DNA gyrase, which are essential for DNA replication and repair. For instance, the U.S.

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Pharmaceutical Companies Government Pharmaceuticals DNA 72