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What are the preclinical characteristics of ISM6331, including its efficacy, safety profile, and drug metabolism and pharmacokinetics (DMPK) properties? The system optimised the molecules that were most likely to succeed in terms of potency, metabolicstability, synthetic accessibility, and more.
The continued popularity of these different ring systems means that an awareness of their potential routes of metabolism is helpful for medicinal chemists. 2012, 55, 6002-6020 ([link] Pyrroles as targets for oxidation Pyrroles are extensively metabolised by cytochrome P450s with oxidation preferred on the carbons adjacent to the nitrogen.
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