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With 13 preclinical candidates and three AI-designed drugs currently undergoing clinical trials, Insilico is spearheading a revolution in cancer treatment and beyond. Can you provide a summary of the key findings and implications of the preclinical studies on ISM6331 for the treatment of advanced solid tumours?
The continued popularity of these different ring systems means that an awareness of their potential routes of metabolism is helpful for medicinal chemists. 2012, 55, 6002-6020 ([link] Pyrroles as targets for oxidation Pyrroles are extensively metabolised by cytochrome P450s with oxidation preferred on the carbons adjacent to the nitrogen.
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