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ViiV Healthcare presents positive proof-of-concept findings for GSK3640254, a novel, investigational maturation inhibitor for the treatment of HIV

The Pharma Data

The study showed the antiviral activity of GSK’254, establishing a relationship between dose and antiviral response, with the 140 mg and 200 mg doses showing the greatest reduction in plasma HIV-1 RNA. Shionogi joined in October 2012. At the conclusion of the study, the largest mean changes in viral load were -1.5 log 10 and -2.0

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Oditrasertib,

New Drug Approvals

citation needed ] The pharmacokinetic properties of obeldesivir and improved was first published by Chinese researchers in May 2022. 2-NTP , an analog of ATP, inhibits the SARS-CoV-2 RNA-dependent RNA polymerase replication and transcription of viral RNA. Saunders, O. Zhang, L.; 22 (8): 2705–2707. . ^ Gordon, C.

RNA 52
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TACACICLIB, AUR-102, AURIGENE

New Drug Approvals

May 30; 31(11): 2498-510, 2012). As a TFIIH subunit, CDK7 phosphorylates the CTD (Carboxy-Terminal-Domain) of the largest subunit of RNA polymerase II (pol II). In addition to CDK7, other CDKs have been reported to phosphorylate and regulate RNA pol (II) CTD. Mar 23;25(6):839-50. 2007; Ganuza et al., 13, 261-91, 1997).