Broad Institute

JANUARY 14, 2025

A long-awaited strategy Vallabh and Minikel have been studying prion disease since 2012, after Vallabhs mother passed away from a form of the disease called fatal familial insomnia and Vallabh found out that she had inherited the disease-causing mutation. This has the potential to be a really promising strategy.

Disease 144

Disease DNA Protein Production Treatment 144

Drug Target Review

NOVEMBER 1, 2023

We support the drug discovery projects of the CCDD with assay development and screening, biophysics, structural biology and recombinant protein production. With all these diverse methods we characterise protein-ligand interactions in many ways.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

Codon

MARCH 24, 2024

In 2012, an Israeli company called Protalix gained approval for their plant-based enzyme product for Gaucher’s disease. Kanuma, their FDA-approved protein product for rare lysosomal diseases, is “purified from the egg white of transgenic hens.”

Engineering 86

Engineering Vaccine Production RNA 86

Codon

AUGUST 10, 2023

PNAS (2012). Link The PURE system for the cell-free synthesis of membrane proteins , by Kuruma Y. & Link An integrated cell-free metabolic platform for protein production and synthetic biology , by Jewett M.C. . & Charpentier E. Philosophical Transactions of the Royal Society B (2016). Science (2018).

DNA 95

DNA Cell Biology Molecular Biology Engineering 95

Codon

AUGUST 10, 2023

PNAS (2012). Link The PURE system for the cell-free synthesis of membrane proteins , by Kuruma Y. & Link An integrated cell-free metabolic platform for protein production and synthetic biology , by Jewett M.C. Nature (2012). Nature (2012). . & Charpentier E. Science (2018). & Ueda T.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52