Broad Institute

OCTOBER 16, 2024

William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce millions of doses of COVID-19 vaccines The groundbreaking, scalable technology is widely used in laboratories around the world today to efficiently produce large amounts of protein and RNA. Merkin (left) and F.

Vaccine 64

Vaccine RNA Laboratories Molecular Biology 64

The Pharma Data

OCTOBER 21, 2020

The long-acting regimen of cabotegravir and rilpivirine is an investigational regimen for the treatment of HIV-1 infection in adults to replace the current antiretroviral regimen in patients who are virologically stable and suppressed (HIV-1 RNA less than 50 copies/mL). Shionogi joined in October 2012.

Clinical Development 52

Clinical Development Therapies Clinical Trials Treatment 52

The Pharma Data

AUGUST 29, 2020

This analysis confirms that as a small interfering RNA (siRNA), inclisiran provides a remarkably consistent treatment profile. Inclisiran will potentially be the first and only LDL-C-lowering small-interfering RNA (siRNA) treatment. Heart disease and stroke Statistics-2012 update. from baseline (observed values) 2­. Circulation.

Treatment 52

Treatment Disease Therapies Trials 52

Drug Target Review

MARCH 21, 2024

Additionally, the COVID-19 RNA vaccines have already demonstrated how safe RNA can be, and we look forward to seeing additional safety data on RNA approaches as the field continues to grow. 2012 Aug 1;181(2):392-400. AAV-based therapies often can’t be dosed more than once due to concerns about an immune response.

Therapies 65

Therapies RNA Immune Response Treatment 65

Drug Target Review

JULY 11, 2024

Ribonucleic acid (RNA) sequencing is an established approach, in which messenger RNA (mRNA) transcripts within the cell are used to produce a readout of the proteins they code for on the cell surface. Roman also serves as the Director of the Department of Translational Genomics and as Professor at the University of Cologne.

Therapies 56

Therapies RNA Pharma Companies Disease 56

New Drug Approvals

JANUARY 9, 2024

May 30; 31(11): 2498-510, 2012). As a TFIIH subunit, CDK7 phosphorylates the CTD (Carboxy-Terminal-Domain) of the largest subunit of RNA polymerase II (pol II). In addition to CDK7, other CDKs have been reported to phosphorylate and regulate RNA pol (II) CTD. Mar 23;25(6):839-50. 2007; Ganuza et al., 13, 261-91, 1997).

Production 62

Production DNA RNA Regulations 62

Drug Target Review

AUGUST 9, 2023

14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts. Many potential toxic effects have been suggested, including the mis-splicing of the Stathmin-2 RNA transcript. Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis.” Neuron vol. Science vol.

RNA 98

RNA Regulations Disease DNA 98

New Drug Approvals

SEPTEMBER 7, 2024

Coronaviruses are enveloped, positive-sense, single-stranded RNA viruses. The genomic RNA of CoVs has a 5′-cap structure and 3′-poly-A tail and contains at least 6 open reading frames (ORFs). 2012, 55, 9069). μM and <0.1mM for 229E hCoV and SARS-CoV-23C-like (3CL) proteases , respectively.

RNA 62

RNA Virus Therapies Pharmaceuticals 62

Codon

JUNE 11, 2024

Their solution was to fuse hairpins, little loops made from RNA or DNA, at various positions along the DNA strand that was being sequenced. In 2012 , they found it in the form of DNA polymerase, an enzyme that replicates the genome prior to cell division.

DNA 73

DNA Engineering RNA Small Molecule 73

Broad Institute

JANUARY 30, 2024

In 2012, he joined the Broad Institute as a postdoctoral researcher in the lab of Broad core institute member Deborah Hung , who is also a professor at Harvard Medical School and MGH, an infectious disease physician at BWH, and an attending critical care physician in the Medical Intensive Care Unit at BWH.

Hospitals 137

Hospitals Medical Schools Virus Science 137

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. And given that RNA and lipid nanoparticle synthesis is highly efficient compared to typical bioproduction, it’s likely that the company could have scaled to billions of doses.

Engineering 85

Engineering Vaccine Production RNA 85

The Pharma Data

OCTOBER 27, 2021

The primary endpoint is the proportion of study actors with HIV-1 RNA viral cargo ? In 2012, Merck certified islatravir (4’-ethynyl-2-fluoro-2’-deoxyadenosine or EFdA) from the Yamasa Corporation grounded in Choshi, Japan. 50 c/ mL at Week 24. Their safety and efficacity haven’t yet been established.

Treatment 52

Treatment Clinical Trials Clinical Development Research Laboratories 52

Codon

MARCH 12, 2023

The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Eterna is an online game (there’s also an app) where anyone on the internet can solve puzzles by manipulating RNA sequences and simulating the results. Biology is a Burrito.

DNA 52

DNA Engineering Therapies RNA 52

PLOS: DNA Science

DECEMBER 21, 2023

Martin’s Press was about to publish my book about gene therapy in 2012, my agent urged me to start blogging. I am grateful to PLoS for giving me this voice for more than a decade, and free reign to cover anything that even remotely involves DNA or RNA. The Birth of DNA Science When St. COVID posts number more than 100.

DNA 105

DNA Vaccine Science Therapies 105

Codon

JUNE 26, 2023

A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. RNA-guided nucleases, called HERMES, are common across eukaryotes and the viruses that infect them. Paper by Sha G. in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. RNA-guided nucleases, called HERMES, are common across eukaryotes and the viruses that infect them. Paper by Sha G. in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

AUGUST 10, 2023

Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. PNAS (2012). Link In vitro integration of ribosomal RNA synthesis, ribosome assembly, and translation , by Jewett M.C. Nature (2012). Nature (2012). & Charpentier E. Science (2018). Nature (2005).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

AUGUST 10, 2023

Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. PNAS (2012). Link CRISPR-Cas →CRISPR-Cas: biology, mechanisms and relevance , by Hille F. & & Charpentier E. Philosophical Transactions of the Royal Society B (2016). Science (2018). Nature Biotechnology (2021).

DNA 91

DNA Cell Biology Molecular Biology Engineering 91

The Pharma Data

OCTOBER 30, 2020

Veklury is a nucleotide analog RNA polymerase inhibitor and works by stopping replication of SARS-CoV-2. The prescription version of the single-use Sklice was first available in 2012. It is widely available in U.S. hospitals. The most common side effects (>5%) include nausea and elevated liver enzymes. .

FDA Approval 52

FDA Approval Hospitals Treatment FDA 52