2012 RNA Virus 
Codon
AUGUST 26, 2024
When COVID-19 emerged in 2019, by contrast, mRNA vaccines developed by Pfizer and Moderna took just 326 days from the initial sequencing of the virus to gaining approval for emergency use. These drugs would be ideal tools to bridge the wait for a vaccine against a quickly-spreading virus.
Drug Target Review
MARCH 21, 2024
Because mRNA is not a virus, it doesn’t have to meet biosafety requirements for manufacturing and administration that an AAV approach would need. Additionally, the COVID-19 RNA vaccines have already demonstrated how safe RNA can be, and we look forward to seeing additional safety data on RNA approaches as the field continues to grow.
The Pharma Data
MARCH 9, 2021
The study showed the antiviral activity of GSK’254, establishing a relationship between dose and antiviral response, with the 140 mg and 200 mg doses showing the greatest reduction in plasma HIV-1 RNA. Shionogi joined in October 2012. At the conclusion of the study, the largest mean changes in viral load were -1.5 log 10 and -2.0
Broad Institute
JANUARY 30, 2024
He has also emerged in recent years as a skilled and relatable science communicator, renowned for his efforts at Broad and beyond during the COVID-19 pandemic to unpack the fast-moving research on the new virus in an accessible way and give practical advice about masking, vaccines, and other public health measures.
New Drug Approvals
SEPTEMBER 7, 2024
Coronaviruses are enveloped, positive-sense, single-stranded RNA viruses. The genomic RNA of CoVs has a 5′-cap structure and 3′-poly-A tail and contains at least 6 open reading frames (ORFs). 2012, 55, 9069). μM and <0.1mM for 229E hCoV and SARS-CoV-23C-like (3CL) proteases , respectively.
PLOS: DNA Science
OCTOBER 24, 2024
In those early days, politicians and government officials who’d never heard terms like “cytokine storm” and “RNA virus” were suddenly charged with explaining what was happening. But much of it was in the unfamiliar language of virology and immunology, public health and epidemiology.
Codon
JUNE 11, 2024
Their solution was to fuse hairpins, little loops made from RNA or DNA, at various positions along the DNA strand that was being sequenced. In 2012 , they found it in the form of DNA polymerase, an enzyme that replicates the genome prior to cell division. 3 This speed varies depending on the organism.
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