NIOSH Science Blog: Drugs

MAY 1, 2024

Since 2013, construction workers have suffered approximately 300 fatal and 20,000 nonfatal fall-related injuries per year (CPWR 2024). Many of these falls occurred in the construction industry, and significantly impact construction employers, workers, and their families.

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Science 90

Covalent Modifiers

JULY 30, 2024

Here we provide a personal perspective on the effort leading to our initial report of KRASG12C inhibitors in 2013, and the decade of discoveries that followed. [link] RAS proteins, central drivers of cancer, appeared ‘undruggable’ for almost 30 years. Direct RAS inhibitors turn 10

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SCIENMAG: Medicine & Health

JUNE 14, 2023

Toronto, ON, June 15, 2023 – The rate of hospital encounters for benzodiazepine-related toxicity rose by 67 per cent for young adults (aged 19 to 24) and 44 per cent for youth (aged 18 or below) in Ontario between 2013 and 2020, according to a new study from ICES and Unity Health Toronto. Credit: Ontario […]

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Hospitals 81

Broad Institute

APRIL 25, 2024

Christian Happi and Pardis Sabeti on the campus of Redeemer's University in 2013. Christian Happi and Pardis Sabeti on the campus of Redeemer's University in 2013. In 2013, Happi and Sabeti applied to the World Bank for support to establish a genomic center of excellence in Nigeria. Scientists train at ACEGID in October 2013.

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Covalent Modifiers

APRIL 18, 2024

In 2013, Shokat and co-workers achieved a groundbreaking feat by covalently targeting a previously undiscovered allosteric pocket (switch II pocket (SWIIP)) of KRASG12C. This breakthrough led to the development and approval of sotorasib (AMG510) and adagrasib (MRTX849), revolutionizing the treatment of KRASG12C-dependent lung cancer.

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Therapies Treatment 85

Drugs.com

DECEMBER 11, 2023

11, 2023 -- When an HIV-infected child known as the 'Mississippi baby' was given powerful antiretroviral drugs within hours of birth in 2013 and then appeared to be rid of HIV, people wondered if it might be replicated in other. MONDAY, Dec.

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Drugs 75

Chemical Biology and Drug Design

SEPTEMBER 12, 2023

This review highlights the recent advances (2013–2023) in the pharmacology of rhodanine-linked quinoline hybrids as more effective antimicrobial agents. In the drug development process, linker hybrids acquire the top position due to their excellent π-stacking and Van der Waals interaction with the DNA active sites of pathogens.

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DNA Drug Development Drugs 100

Drugs.com

MARCH 8, 2024

FRIDAY, March 8, 2024 -- Ever since one child, dubbed the 'Mississippi baby,' went into drug-free remission of HIV in 2013, experts have wondered if giving treatment within hours of birth might do the same for others.The results of a new trial.

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Treatment Trials Drugs 59

Broad Institute

NOVEMBER 2, 2023

Established in 2013, the Bayer-Broad collaboration is uniquely structured to encourage close coordination and ongoing, face-to-face interactions between researchers at both organizations. “Bayer’s established collaboration with the Broad Institute has already resulted in three clinical oncology candidates over the past decade.

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Science Daily: Pharmacology News

JUNE 8, 2023

C for the most recent decade (2013 to 2022) above pre-industrial levels. Human-induced warming, largely caused by the burning of fossil fuels, reached an average of 1.14°C This is up from 1.07°C C between 2010 and 2019. Human-induced warming is now increasing at a pace of over 0.2°C C per decade.

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Broad Institute

MARCH 8, 2024

Any questions about the Next Generation Awards program can be directed to Jacob Herman at jherman@broadinstitute.org. Hung (2010 - 2011 awardee) James Bradner Jake Jaffe 2011 - 2012 Awardees Feng Zhang John Rinn Mitchell Guttman Anne Carpenter 2010 - 2011 Awardees Deborah T.

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Research 52

Covalent Modifiers

FEBRUARY 6, 2024

However, there has been a resurgence in covalent drug design following the success of several covalent drugs such as boceprevir (2011), ibrutinib (2013), neratinib (2017), dacomitinib (2018), zanubrutinib (2019), and many others.

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Drugs Research 71

Perficient: Drug Development

FEBRUARY 22, 2024

I worked on many projects with them in my early career (2003-2013). By the time I left the account in 2013, Atlas had several years of being the only van line doing online estimates well, and their competitors were working hard and fast to catch up. Atlas Van Lines is in the moving and relocation industry. We did amazing work together.

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Drugs.com

JULY 8, 2024

MONDAY, July 8, 2024 -- Wartime appears to increase the risk of chronic pain for military women, a new study suggests.Active-duty servicewomen who served between 2006 and 2013 – a period of heightened combat deployments – had a significantly inc.

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NIH Director's Blog: Drug Discovery

MAY 9, 2013

2013 Apr 25;496(7446):498-503. Epub 2013 Apr 17. [2] 2013 Apr 25;496(7446):494-7. 2013 Apr 25;496(7446):443-4. [3] Fishy as it sounds, it’s an amazing system to learn about biology. References: [1] The zebrafish reference genome sequence and its relationship to the human genome. Howe K, et al. doi: 10.1038/nature12111.

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LifeSciVC

JANUARY 12, 2024

With a little over 50 new startups raising capital in 4Q24, we’re back to levels not seen for nearly a decade, at the start of the biotech secular bull market in 2013-2014.

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Marketing Science 108

Common Sense for Drug Policy Blog

JUNE 24, 2024

In 2013, the UNODC established an Early Warning Advisory (EWA) as a response at the global level to the increasing prevalence of NPS [ 85 ]. Since its launch in 2013 until the beginning of 2022, a total of 136 countries had reported a total of over 1100 individual substances [ 86 ].

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Marketing International Drugs 52

Broad Institute

AUGUST 23, 2023

BSRP and BSSP, since 2003 and 2013 respectively, have taught students research and laboratory skills and helped them feel a sense of belonging in STEM.

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The Pharma Data

SEPTEMBER 12, 2020

Alleged British computer hacker Lauri Love was arrested in 2013 on suspicion of stealing data from the FBI, Nasa and other US agencies. In 2018, he won his appeal against extradition to the US.

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NIH Director's Blog: Drug Development

FEBRUARY 4, 2014

2013 August. [2] 2013 Apr 11. [3] 2013 August. References: [1] Trial watch: phase II and phase III attrition rates 2011-2012. Arrowsmith J, Miller P. Nat Rev Drug Discov. 2] Genetics: a gene of rare effect. 3] Validating therapeutic targets through human genetics. Plenge RM, Scolnick EM, Altshuler D. Nat Rev Drug Discov.

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LifeSciVC

APRIL 26, 2024

Beyond simply backing great science (separating the wheat from the chafe), setting a company up properly is critical, and early choices can get locked into the DNA of the company.

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DNA Science Marketing Clinical Trials 107

Agency IQ

AUGUST 4, 2023

The Drug Supply Chain Security Act (DSCSA) and upcoming deadlines The Drug Supply Chain Security Act (DSCSA) was enacted in 2013 as part of the Drug Quality and Security Act (DQSA), following several drug counterfeiting scandals in which falsified medical products entered the supply chain. Fill out the form to read the full article.

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FDA Science Production Drugs 52

The Pharma Data

MAY 5, 2021

FDA officials said that the number of a product specific guidances (PSGs) issued by the Office of Generic Drugs (OGD) has increased steadily since FY 2013. FDA issued a grand total of 1,558 PSGs from FY 2013 to FY 2020. In FY 2019, 252 were issued, as were 208 in FY 2018. .

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PLOS: DNA Science

MAY 16, 2024

” I’ve long thought that SARS-CoV-2, or an immediate viral predecessor, emerged years before 2019 – at least as far back as 2013. The evidence for an earlier origin lies in viral genome sequences, specifically bat coronavirus RaTG13.

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Eye on FDA

MARCH 7, 2024

Since 1983 with the passage of the Orphan Drug, there has been increased attention and focus to bringing new treatments into play for rare diseases, with increasing numbers of new orphan drug approvals seen between 2013-2022 according to the National Institutes of Health.

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FDA Disease Government Drugs 78

Drug Target Review

APRIL 4, 2024

In 2013, Nicholas co-founded IRLAB Sweden. In 2006, Carlsson Research was sold to NeuroSearch and changed name to NeuroSearch Sweden. In 2010 he was appointed Executive Vice President, Research at NeuroSearch. Nicholas continued to serve as CEO of NeuroSearch Sweden through 2012.

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Eye on FDA

FEBRUARY 22, 2022

In a recent blog posting, I looked back at the profile of FDA press releases over the period 2013-2021 (See What They Said 2021 – An Overview of FDA Press Statements ). But mostly, we are just tired – there is a strong sense of COVID fatigue, not just among people, but it seems even institutions. Even perhaps FDA.

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PLOS: DNA Science

MARCH 21, 2024

She passed away in 2013. Each of their children would face a 1 in 4 chance of inheriting the disease. The boy was accepted into the clinical trial in Italy and received the gene therapy in 2011, but it was too late for Liviana. Then in 2014 Amy had triplets and one of them, Cecilia, inherited MLD – she had gene therapy at 9 months.

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Therapies Clinical Trials DNA Trials 95

thought leadership

AUGUST 15, 2023

The Significance of DSCSA and Serialization in the Pharmaceutical Supply Chain The Drug Supply Chain Security Act (DSCSA) is a federal law enacted in 2013 to enhance the security and traceability of pharmaceutical products within the United States supply chain.

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The Pharma Data

FEBRUARY 22, 2022

In 2013, she was appointed Finance Director of the Artémis Group. From 2009 to 2016, he led global oncology development at AstraZeneca, delivering TAGRISSO and LYNPARZA, including Senior Vice President, GMD Head of Oncology and Lead, China GMD (2013-2016).

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Clinical Trials DNA Science Clinical Development 52

The Pharma Data

DECEMBER 22, 2020

from the University of Mississippi in Jackson, and colleagues explored the association between goal-striving stress (GSS) and RKFD among 2,630 African Americans using data from the Jackson Heart Study (2000 to 2004 and 2009 to 2013). Loretta Cain-Shields, Ph.D., The researchers found that the incidence of RKFD in this sample was 7.34

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The Pharma Data

JANUARY 26, 2021

from the American Cancer Society in Atlanta, and colleagues estimated smoking-related population-attributable fractions (PAFs) for cancer mortality in those ages 30 years and older in 2013 to 2017 in 152 metropolitan or micropolitan statistical areas (MMSAs). Farhad Islami, M.D.,

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Drug Target Review

OCTOBER 26, 2023

Molecular therapy 21 , 109-118 (2013). Nature Communications 6 , 6246 (2015). Münch RC, et al. Displaying high-affinity ligands on adeno-associated viral vectors enables tumor cell-specific and safe gene transfer. Li C, Samulski RJ. Engineering adeno-associated virus vectors for gene therapy. Nature Reviews Genetics 21 , 255-272 (2020).

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Sygnature Discovery

SEPTEMBER 5, 2024

Full Audit Trail: Titian Software Limited is compliant with the requirements of ISO 27001: 2013 Detailed records ensure regulatory adherence. Cost Reduction: Maximise compound usage due to reduced wastage. Optimizes resource utilization.

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Compound Screening Production Drugs 52

Broad Institute

APRIL 26, 2024

Image on the left: Eli and Edythe Broad tour the Stanley Building as it was under construction in 2013. The Stanley Building added 375,000 square feet to Broad’s campus and allowed Broadies who had been conducting research in separate buildings to come together.

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International Research Disease 52

Common Sense for Drug Policy Blog

JULY 9, 2023

Injection Drug Use in the EU "Among first-time clients entering specialised drug treatment in 2021, or most recent year available, with heroin as their primary drug, 19% (down from 38% in 2013) reported injecting as their main route of administration.

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Eye on FDA

JUNE 14, 2023

But the numbers began to dwindle and 2013 was the last time the office even issued 12 letters within a year (it did 23 that year). Enforcement Track Record – Looking all the way back to 1998, FDA issued a peak of 156 Untitled or Warning Letters in a single year (the prior year it had issued 139).

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