Covalent Modifiers

APRIL 18, 2024

In 2013, Shokat and co-workers achieved a groundbreaking feat by covalently targeting a previously undiscovered allosteric pocket (switch II pocket (SWIIP)) of KRASG12C. This breakthrough led to the development and approval of sotorasib (AMG510) and adagrasib (MRTX849), revolutionizing the treatment of KRASG12C-dependent lung cancer.

Therapies 214

Therapies Treatment 214

Drugs.com

DECEMBER 11, 2023

11, 2023 -- When an HIV-infected child known as the 'Mississippi baby' was given powerful antiretroviral drugs within hours of birth in 2013 and then appeared to be rid of HIV, people wondered if it might be replicated in other. MONDAY, Dec.

Drugs 189

Drugs 189

Science Daily: Pharmacology News

JUNE 8, 2023

C for the most recent decade (2013 to 2022) above pre-industrial levels. Human-induced warming, largely caused by the burning of fossil fuels, reached an average of 1.14°C This is up from 1.07°C C between 2010 and 2019. Human-induced warming is now increasing at a pace of over 0.2°C C per decade.

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Drugs.com

MARCH 8, 2024

FRIDAY, March 8, 2024 -- Ever since one child, dubbed the 'Mississippi baby,' went into drug-free remission of HIV in 2013, experts have wondered if giving treatment within hours of birth might do the same for others.The results of a new trial.

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Treatment Trials Drugs 147

Drugs.com

JULY 8, 2024

MONDAY, July 8, 2024 -- Wartime appears to increase the risk of chronic pain for military women, a new study suggests.Active-duty servicewomen who served between 2006 and 2013 – a period of heightened combat deployments – had a significantly inc.

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Covalent Modifiers

FEBRUARY 6, 2024

However, there has been a resurgence in covalent drug design following the success of several covalent drugs such as boceprevir (2011), ibrutinib (2013), neratinib (2017), dacomitinib (2018), zanubrutinib (2019), and many others.

Drugs 182

Drugs Research 182

National Drug & Alcohol Research Centre Blog

DECEMBER 4, 2023

We converted information on monthly sales of methadone, sublingual buprenorphine (+/- naloxone) and buprenorphine between 2013 and 2022 into an estimate of the number of clients receiving these medicines each month, based on average doses in Australia (“client-months”). Chidwick, K., Farrell, M., & Degenhardt, L. Vol 123, p.

Treatment 133

Treatment Community Pharmacies Pharmacy International 133

Antidote

OCTOBER 3, 2022

Complement 3 Glomerulopathy, most commonly shortened to C3G or C3G kidney disease, is a rare type of kidney disease that has only been diagnosed since 2013. “C3” C3” refers to a blood protein that has a vital role in the immune system, and “G” is for the damage to glomeruli in the kidneys.

Disease 98

Disease 98

ASPET

AUGUST 21, 2024

In response, Comprehensive In Vitro Proarrhythmia Assay (CiPA) and Exposure-Response Modeling were proposed in 2013 to reinforce proarrhythmic risk assessment. However, those guidelines unfortunately hampered the development of some potentially valuable drug candidates despite not being proven to be proarrhythmic.

Compliance 100

Compliance Pharmacokinetics Drugs Engineering 100

NIOSH Science Blog: Drugs

MAY 1, 2024

Since 2013, construction workers have suffered approximately 300 fatal and 20,000 nonfatal fall-related injuries per year (CPWR 2024). Many of these falls occurred in the construction industry, and significantly impact construction employers, workers, and their families.

Science 90

Science 90

Drug Target Review

MARCH 7, 2024

In 2013 2 , Dr Shokat and his team developed the first cancer drugs to stop a different K-Ras mutation, G12C. Their 2013 research allowed them to develop a template for chemicals that reliably found their way into that corner of the protein. Nature [Internet] 2013 November 20 [2024 March 6]; 503:548-51. Available from: [link]

Treatment 98

Treatment Therapies Clinical Trials Research 98

SCIENMAG: Medicine & Health

JUNE 14, 2023

Toronto, ON, June 15, 2023 – The rate of hospital encounters for benzodiazepine-related toxicity rose by 67 per cent for young adults (aged 19 to 24) and 44 per cent for youth (aged 18 or below) in Ontario between 2013 and 2020, according to a new study from ICES and Unity Health Toronto. Credit: Ontario […]

Hospitals 81

Hospitals 81

Chemical Biology and Drug Design

SEPTEMBER 12, 2023

This review highlights the recent advances (2013–2023) in the pharmacology of rhodanine-linked quinoline hybrids as more effective antimicrobial agents. In the drug development process, linker hybrids acquire the top position due to their excellent π-stacking and Van der Waals interaction with the DNA active sites of pathogens.

DNA 100

DNA Drug Development Drugs 100

Broad Institute

NOVEMBER 2, 2023

Established in 2013, the Bayer-Broad collaboration is uniquely structured to encourage close coordination and ongoing, face-to-face interactions between researchers at both organizations. “Bayer’s established collaboration with the Broad Institute has already resulted in three clinical oncology candidates over the past decade.

Therapies 105

Therapies Research Small Molecule Clinical Trials 105

Broad Institute

MARCH 8, 2024

Any questions about the Next Generation Awards program can be directed to Jacob Herman at jherman@broadinstitute.org. Hung (2010 - 2011 awardee) James Bradner Jake Jaffe 2011 - 2012 Awardees Feng Zhang John Rinn Mitchell Guttman Anne Carpenter 2010 - 2011 Awardees Deborah T.

Research 52

Research 52

NIH Director's Blog: Drug Discovery

MAY 9, 2013

2013 Apr 25;496(7446):498-503. Epub 2013 Apr 17. [2] 2013 Apr 25;496(7446):494-7. 2013 Apr 25;496(7446):443-4. [3] Fishy as it sounds, it’s an amazing system to learn about biology. References: [1] The zebrafish reference genome sequence and its relationship to the human genome. Howe K, et al. doi: 10.1038/nature12111.

Disease 52

Disease Science International Regulations 52

Perficient: Drug Development

FEBRUARY 22, 2024

I worked on many projects with them in my early career (2003-2013). By the time I left the account in 2013, Atlas had several years of being the only van line doing online estimates well, and their competitors were working hard and fast to catch up. Atlas Van Lines is in the moving and relocation industry. We did amazing work together.

Marketing 116

Marketing Production Government Regulations 116

Perficient: Drug Development

JANUARY 30, 2025

Kubernetes was invented by Google in 2013 and was handed over to CNCF (Cloud Native Computing Foundation), which is a part of the Linux Foundation. Kubernetes is an Open Source Container Orchestration tool that automates Containerized Applications’ deployment, scaling, and management.

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LifeSciVC

JANUARY 12, 2024

With a little over 50 new startups raising capital in 4Q24, we’re back to levels not seen for nearly a decade, at the start of the biotech secular bull market in 2013-2014.

Marketing 113

Marketing Science 113

Common Sense for Drug Policy Blog

JUNE 24, 2024

In 2013, the UNODC established an Early Warning Advisory (EWA) as a response at the global level to the increasing prevalence of NPS [ 85 ]. Since its launch in 2013 until the beginning of 2022, a total of 136 countries had reported a total of over 1100 individual substances [ 86 ].

Marketing 52

Marketing International Drugs 52

Broad Institute

AUGUST 23, 2023

BSRP and BSSP, since 2003 and 2013 respectively, have taught students research and laboratory skills and helped them feel a sense of belonging in STEM.

Research 52

Research Laboratories 52

Drug Hunter

AUGUST 21, 2023

2013 , 56 (1), 2-12. Dennis obtained his PhD in Organic Chemistry from the University of Göttingen in 2013 specializing in carbohydrate chemistry and transition-metal catalysis. He worked at the University of Kyoto in 2011 and at the University of Münster in 2013. Pharm Res 2022 , 39 , 1321-1341. link] (Pfizer) Di, L.;

Drugs 206

Drugs Disease Targeted Protein Degradation Screening Hits 206

LifeSciVC

APRIL 26, 2024

Beyond simply backing great science (separating the wheat from the chafe), setting a company up properly is critical, and early choices can get locked into the DNA of the company.

DNA 112

DNA Science Marketing Clinical Trials 112

The Pharma Data

SEPTEMBER 12, 2020

Alleged British computer hacker Lauri Love was arrested in 2013 on suspicion of stealing data from the FBI, Nasa and other US agencies. In 2018, he won his appeal against extradition to the US.

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NIH Director's Blog: Drug Development

FEBRUARY 4, 2014

2013 August. [2] 2013 Apr 11. [3] 2013 August. References: [1] Trial watch: phase II and phase III attrition rates 2011-2012. Arrowsmith J, Miller P. Nat Rev Drug Discov. 2] Genetics: a gene of rare effect. 3] Validating therapeutic targets through human genetics. Plenge RM, Scolnick EM, Altshuler D. Nat Rev Drug Discov.

Drug Development 52

Drug Development Disease Drugs Pharmaceuticals 52

Agency IQ

AUGUST 4, 2023

The Drug Supply Chain Security Act (DSCSA) and upcoming deadlines The Drug Supply Chain Security Act (DSCSA) was enacted in 2013 as part of the Drug Quality and Security Act (DQSA), following several drug counterfeiting scandals in which falsified medical products entered the supply chain. Fill out the form to read the full article.

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FDA Science Production Drugs 52

The Pharma Data

MAY 5, 2021

FDA officials said that the number of a product specific guidances (PSGs) issued by the Office of Generic Drugs (OGD) has increased steadily since FY 2013. FDA issued a grand total of 1,558 PSGs from FY 2013 to FY 2020. In FY 2019, 252 were issued, as were 208 in FY 2018. .

Drug Development 52

Drug Development FDA Drugs Production 52

Elrig

APRIL 7, 2025

A long-time supporter of ELRIG, Dr Trezise has been anactive volunteer since 2013, contributing asScientific Programme Chair, Early Career Professionals Work Group Leader, and Head of the Innovation Work Group. He joined the ELRIG Board in 2017 and remains dedicated todriving scientific innovation and industry engagement.

Assay Development 59

Assay Development Laboratories Science Drugs 59

thought leadership

AUGUST 15, 2023

The Significance of DSCSA and Serialization in the Pharmaceutical Supply Chain The Drug Supply Chain Security Act (DSCSA) is a federal law enacted in 2013 to enhance the security and traceability of pharmaceutical products within the United States supply chain.

Drugs 40

Drugs Pharmaceuticals Production 40

Drug Target Review

MARCH 3, 2025

Since 2013, Jens has been the head of the Developmental and Cellular Biology group at the Luxembourg Centre for Systems Biomedicine (LCSB) and a Professor at the University of Luxembourg. He worked as a postdoctoral researcher at the Institute for Molecular Biotechnology in Vienna, Austria.

Disease 52

Disease Treatment Therapies Cell Biology 52

Eye on FDA

MARCH 7, 2024

Since 1983 with the passage of the Orphan Drug, there has been increased attention and focus to bringing new treatments into play for rare diseases, with increasing numbers of new orphan drug approvals seen between 2013-2022 according to the National Institutes of Health.

FDA 78

FDA Disease Government Drugs 78

The Pharma Data

DECEMBER 22, 2020

from the University of Mississippi in Jackson, and colleagues explored the association between goal-striving stress (GSS) and RKFD among 2,630 African Americans using data from the Jackson Heart Study (2000 to 2004 and 2009 to 2013). Loretta Cain-Shields, Ph.D., The researchers found that the incidence of RKFD in this sample was 7.34

Disease 52

Disease Research 52

Drug Target Review

APRIL 4, 2024

In 2013, Nicholas co-founded IRLAB Sweden. In 2006, Carlsson Research was sold to NeuroSearch and changed name to NeuroSearch Sweden. In 2010 he was appointed Executive Vice President, Research at NeuroSearch. Nicholas continued to serve as CEO of NeuroSearch Sweden through 2012.

Disease 105

Disease Treatment Licensing Licensing 105

Sygnature Discovery

SEPTEMBER 5, 2024

Full Audit Trail: Titian Software Limited is compliant with the requirements of ISO 27001: 2013 Detailed records ensure regulatory adherence. Cost Reduction: Maximise compound usage due to reduced wastage. Optimizes resource utilization.

Compound Screening 52

Compound Screening Production Drugs 52

Broad Institute

APRIL 26, 2024

Image on the left: Eli and Edythe Broad tour the Stanley Building as it was under construction in 2013. The Stanley Building added 375,000 square feet to Broad’s campus and allowed Broadies who had been conducting research in separate buildings to come together.

International 52

International Research Disease 52

Common Sense for Drug Policy Blog

JULY 9, 2023

Injection Drug Use in the EU "Among first-time clients entering specialised drug treatment in 2021, or most recent year available, with heroin as their primary drug, 19% (down from 38% in 2013) reported injecting as their main route of administration.

Drugs 40

Drugs Treatment 40

The Pharma Data

JANUARY 26, 2021

from the CDC in Atlanta, and colleagues updated 2013 data to examine the proportion of high school students who met the USDA recommendations for fruit and vegetable consumption. Department of Agriculture (USDA) recommendations for fruit and vegetable intake, respectively, in 2017, according to research published in the Jan. Samantha J.

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Disease Research 52