Drug Target Review

DECEMBER 21, 2023

mRNA biology has become widely recognised as a new “drug mine” RNAi drugs are in the market and mRNA vaccines, initially developed for Covid-19, are already in trials for cancer. There must be something different in those diseased cells, some dysregulated pathway that is causing that disease phenotype.

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Disease Small Molecule Vaccine Drugs 106

Broad Institute

JULY 28, 2023

Our pilot study will span: 1) high-resolution EM (electron microscopy) of synaptic excitatory-inhibitory (E-I) balance and nearby glial cells; 2) functional electrophysiological signatures of altered E-I balance by sex in ACC brain slices; 3) molecular correlates of these impairments that can be targeted for recovery of function.

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Medical Schools Hospitals Regulations Research 52

BMG Labtech

FEBRUARY 24, 2025

Post-translational modification of proteins, which includes the alteration of certain amino acid side chains by the introduction of different chemical groups, takes place in eukaryotic and prokaryotic cells. For example, it may result in changes to cell metabolism or lead to alterations in crucial signaling events. Epub 2013 Mar 4.

Small Molecule 52

Small Molecule Disease Licensing Licensing 52

SugarCone Biotech

MAY 28, 2019

Learnings regarding immune geography and cell:cell contact are increasingly important as we consider how best to advance cell therapies for diverse hematologic malignancies and solid tumors ( www.aletabio.com ). Not by coincidence the list overlaps with the phases of the tumor-immunity cycle ( Chen & Mellman, 2013 ).

Therapies 52

Therapies Immune Response Engineering Drug Development 52

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). PNAS (2013).

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DNA Cell Biology Molecular Biology Engineering 95

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). Nature Methods (2013).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

NOVEMBER 1, 2024

Molecular biology has only been around for about 80 years, and tools to study biomolecules (such as DNA and RNA sequencing, or proteomics) have only existed for about half of that time. We are in the absolute infancy of molecular and cell biology, and this means there’s a lot of stuff we still don’t understand.

DNA 114

DNA RNA Molecular Biology Laboratories 114