Metabolism of macrocyclic drugs
Metabolite Tales Blog
JULY 5, 2023
Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. Although in vitro studies showed low metabolic activity, more than 20 metabolites could be identified, resulting from two main routes. link] [9] PHARMACOLOGY/TOXICOLOGY NDA REVIEW AND EVALUATION.
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