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DNA Analysis Finds New Target for Diabetes Drugs

NIH Director's Blog: Drug Development

Credit: Jane Ades, National Human Genome Research Institute, NIH Type 2 diabetes (T2D) tends to run in families, and over the last five years the application of genomic technologies has led to discovery of more than 60 specific DNA variants that contribute to risk. 2013 Aug;12(8):581-94. [3] 2013 Oct 1;123(10):4513-24. [6]

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Gene Therapy Is Here To Stay: Should Bigger Companies Build, Buy, Or Partner?

LifeSciVC

This summer, approvals on both sides of the Atlantic – for beta thalassemia and cerebral adrenoleukodystrophy in the United States and for severe hemophilia A and aromatic L-amino acid carboxylase deficiency in Europe – show that regulators are likely open to green-lighting a range of emerging gene therapies. million price.

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Optical density and absorbance measurements | BMG LABTECH

BMG Labtech

Whether it is determining concentrations of molecules like proteins or DNA, looking at enzyme kinetics for crucial reactions, or measuring something as fundamental as cell growth, you will find references to absorbance or optical density measurements. 2013) Cell Viability Assays. Lets start by looking at some definitions. Anal Biochem.

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Addressing increasingly resistant drugs by infectious agents

Drug Target Review

5 Cytology-based profiling can facilitate antibiotic discovery efforts and, these assays assess cell cycle progression, nuclear and mitochondrial DNA content, mitochondrial DNA replication, nuclear DNA damage, mitochondrial membrane potential, and lysosome structure and function. Trends in Parasitology. (35): Guillermo, S.,

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A Molecular Portrait of ALS and FTD

Drug Target Review

The specific proteins found in these aggregates can vary, but approximately 95 percent of ALS patients and 50 percent of FTD patients develop aggregates containing the TDP-43 protein (short for tar DNA binding protein 43). 14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts.

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ATUZAGINSTAT

New Drug Approvals

gingivalis DNA was detected in postmortem cortices from people with AD and healthy controls, and in CSF of AD patients ( Jan 2019 news on Dominy et al., gingivalis infection led to the appearance of bacterial DNA in the brain, increased brain Aβ42 production, neuroinflammation, and hippocampal degeneration. and Europe.

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Gene-Edited Bananas

Codon

In 2013, a Fusarium fungus — called Tropical Race 4 — was identified in Mozambique. This gene is regulated, in turn, by a small arsenal of other proteins from the MaMADS family. ( has a genome made of DNA. These “other” bits of DNA are called non-coding regions, and some of them make non-coding RNAs.

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