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Metabolism of macrocyclic drugs

Metabolite Tales Blog

Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. Although in vitro studies showed low metabolic activity, more than 20 metabolites could be identified, resulting from two main routes. Ayushi Jain and Khalid Mumtaz, 2022. Avicenna J Med 12:154–156.

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Metabolism of de novo designed macrocyclic drugs

Metabolite Tales Blog

Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. Although in vitro studies showed low metabolic activity, more than 20 metabolites could be identified, resulting from two main routes. Ayushi Jain and Khalid Mumtaz, 2022. Avicenna J Med 12:154–156.