2014 - Drug Discovery Digest

Rates of Distress, Depression Have Doubled Among Transgender Americans Since 2014

Drugs.com

JUNE 24, 2024

MONDAY, June 24, 2024 -- The rate of self-reported mental distress and depression among American adults who identify as transgender or gender-diverse (TGD) has more than doubled between 2014 and 2022, an analysis of federal health data.

DEA Regs Bulk Up with 2014 Anabolic Steroid Control Law Additions

FDA Law Blog: Biosimilars

AUGUST 4, 2023

Because anabolic steroids are also abused to enhance athletic performance and increase muscle strength, Congress has enacted three laws regulating anabolic steroids: the Anabolic Steroid Control Acts of 1990 and 2004, and the Designer Anabolic Steroid Control Act of 2014 (“DASCA”). DASCA became law, amending the CSA, on December 18, 2014.

Regulations

Regulations Production Clinical Trials Drugs

Trial to test monoclonal antibody for virus of growing concern

Drug Discovery World

JULY 2, 2024

The US Centers for Disease Control and Prevention (CDC) identified increases in AFM cases in 2014, 2016, and 2018. AFM has emerged in the United States with spikes in cases every other year, primarily in the late-summer months over the last decade.

Awareness of the link between HPV and cancer has declined

Drug Discovery World

APRIL 17, 2023

Adjei Boakye and colleagues examined data from the Health Information National Trends Survey (HINTS) from five timepoints between 2014 (HINTS 4 cycle 4) and 2020 (HINTS 5 cycle 4). in 2014 to 27.4% in 2014 to 29.5% in 2014 to 28.4% Currently, about 54.5% In 2020, researchers found that 70.2%

Vaccine

Vaccine FDA Approval FDA Science

Interstellar signal linked to aliens was actually just a truck

Science Daily: Pharmacology News

MARCH 7, 2024

Sound waves thought to be from a 2014 meteor fireball north of Papua New Guinea were almost certainly vibrations from a truck rumbling along a nearby road, new research shows. The findings raise doubts that materials pulled last year from the ocean are alien materials from that meteor, as was widely reported.

Research

Research proves synthetic molecule can mitigate heart failure

Drug Discovery World

NOVEMBER 13, 2023

In parallel with our experiments, the biopharmaceutical company worked on improving the efficacy of a molecule described back in 2014, which has potential to treat cardiac diseases,” said Julio Cesar Batista Ferreira, a Professor at the Institute of Biomedical Sciences (ICB-USP).

Research

Research Laboratories Pharmaceuticals Science

The Moving Regulatory Landscape for Gene Therapy Trials in EU: Part 1

thought leadership

JULY 1, 2024

The Benefit of the Common Application Form for GMO Applications GMO Application Not Included in Clinical Trial Regulation With the transition period for the Clinical Trial Regulation No 536/2014 (CTR) complete, as of January 31, 2023, it is now mandatory to use the centralized Clinical Trial Information System (CTIS) for submission of all clinical (..)

Therapies

Therapies Trials Clinical Trials Regulations

Lymphedema Left her 'Miserable, Depressed' Until Specialized Surgery Changed Everything

Drugs.com

DECEMBER 8, 2023

8, 2023 -- Sydnee Meth survived breast cancer, but she wasn’t prepared for the aftereffects of her treatment.Doctors removed the lymph nodes from Meth’s right armpit during her second bout with breast cancer in 2014, and as a. FRIDAY, Dec.

CRISPR in the Clinic

addgene Blog

NOVEMBER 2, 2023

In 2014, we wrote a blog post on CRISPR’s potential for correcting monogenetic diseases. There can be no doubt that CRISPR/Cas9 technology has been a breakthrough for the genome-editing field and the greater scientific community.

Therapies

Therapies Treatment Disease

Jennifer Listgarten

Broad Institute

APRIL 22, 2024

From 2007 to 2017 she was at Microsoft Research, through Cambridge, MA (2014-2017), Los Angeles (2008-2014), and Redmond, WA (2007-2008). She is also a member of the steering committee for the Berkeley AI Research (BAIR) Lab. She completed her Ph.D.

Molecular Biology

Molecular Biology Engineering Science Research

TBD

Broad Institute

AUGUST 31, 2023

TBD By lcopelan@broadinstitute.org August 31, 2023 Yuhan Hao Neptune Bio Related Resources [link] MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Higher infant mortality rates associated with restrictive abortion laws

SCIENMAG: Medicine & Health

JANUARY 17, 2024

Ann Arbor, January 17, 2024 – Contrary to professed intent, the states where abortion access was most restricted experienced the highest levels of infant mortality in the United States from 2014–2018, according to new research in the American Journal of Preventive Medicine, published by Elsevier.

Research

Have You Missed Any FDA Data Submission Requirements? A Look at Substantial Changes and New Requirements

Cytel

JANUARY 3, 2024

Ten years ago this month, in January 2014, the FDA issued the first version of its Technical Conformance Guide (by chance I also found comments provided by my friend Jozef Aerts already complaining about the use of SAS XPORT).

FDA

FDA Packaging

PTC Duchenne drug approval set to be revoked in Europe

BioPharma Drive: Drug Pricing

JANUARY 26, 2024

The EMA’s drugs committee again recommended rescinding an OK for Translarna, which was cleared in 2014 despite questions about its benefit.

Drugs

Juvenile Drug Courts

Common Sense for Drug Policy Blog

DECEMBER 20, 2023

Juvenile Drug Courts "As shown in Figure 13, a total of 420 JDCs were operating across the United States in 2014. Overall, between 2014 and 2021, the number of JDCs in the United States decreased by 30%." This number decreased to 305 by 2019 and again to 296 by the end of 2021.

Drugs

Drugs Treatment

Innovative research on schistosomiasis-associated colorectal cancer (SA-CRC) yields unique insights into genetic mutations and treatment implications

SCIENMAG: Medicine & Health

AUGUST 15, 2023

By utilizing whole exome sequencing on tumor tissues and their non-tumor counterparts obtained from thirty SA-CRC patients diagnosed at Changzheng Hospital from 2014 to […]

Research

Research Treatment Hospitals Disease

Immunotherapy is here to stay

Drug Discovery World

JULY 25, 2023

Triebel founded Immutep SA in 2001 to develop the clinical potential of LAG-3 and stayed with this company through to its acquisition by Prima BioMed in 2014. Around this time, the field of immunotherapy really broke through with the approvals of anti-CTLA-4 (ipilimumab) in 2011 and anti-PD-1 (pembrolizumab & nivolumab) in 2014.

Immune Response

Immune Response Therapies Vaccine Production

‘Ice Bucket Challenge’ funds FDA-approved ALS treatment

Drug Discovery World

OCTOBER 4, 2022

million from the ALS Association, raised by the 2014 social media craze the ‘Ice Bucket Challenge’ Another 40 potential new treatments are being investigated. . In the summer of 2014, over 17 million people posted Ice Bucket Challenge videos to Facebook, including hundreds of celebrities, athletes, and politicians.

FDA Approval

FDA Approval FDA Treatment Clinical Trials

A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic

Broad Institute

APRIL 25, 2024

By Allessandra DiCorato April 25, 2024 As night fell on July 20th, 2014, genomicist Christian Happi was at home with his family in Lagos, Nigeria when he received a phone call he would never forget. On October 20th, 2014, as Ebola continued to spread in Guinea and in neighboring Liberia and Sierra Leone, WHO declared Nigeria free of Ebola.

Virus

Virus Hospitals Disease Government

Alpha Missense

Broad Institute

MARCH 7, 2024

Alpha Missense By lcopelan@broadinstitute.org March 7, 2024 Jun Cheng MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring (..)

Viral Vectors 101: What is a Virus (and a Viral Vector)?

addgene Blog

AUGUST 18, 2023

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Aparna Nathan Raychaudhuri Lab, Division of Genetics/Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital; Department of Biomedical Informatics, Harvard Medical School MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall (..)

Medical Schools

Medical Schools Hospitals

Multimodal protein language models for deciphering protein function

Broad Institute

MAY 23, 2024

MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

Medical Schools

Medical Schools Research Drugs

More American Men Now Opting for Vasectomy

Drugs.com

AUGUST 31, 2023

vasectomy rate increased by 26% between 2014 and 2021, THURSDAY, Aug. 31, 2023 -- Vasectomies are becoming more common in the United States, with rates surging by more than one-quarter during the past decade, a recent study reveals.

International investors abandon UK life sciences

Drug Discovery World

JULY 14, 2023

The average rebate rate between 2014-2021 was 6.88%. Uncompetitive rebate rates The collapse in UK life science investment comes as the clawback rates that manufacturers of branded medicines must pay on their UK revenues (not profits) rocket to 23.6% in 2023, up from 15% in 2022.

International

International Science Government Pharmaceuticals

On fitness models and the modeling of pandemic evolution

Broad Institute

JANUARY 5, 2024

MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

Sharing quality information on all things related to hearing: Wiki4WorldHearingDay2023

NIOSH Science Blog: Drugs

JUNE 7, 2023

Lack of safety and health training and language barriers are among the most frequently cited challenges companies face in promoting safety among immigrant workers (Flynn, 2014). Background The U.S. workforce is ethnically diverse. Unaddressed hearing loss is a serious and costly problem around the world.

International

DDW Cancer Research Summit: Industry experts join the panel

Drug Discovery World

OCTOBER 11, 2023

He joined Taconic Biosciences in 2014 has been the Vice President of Commercial Products since 2017. Spiro Rombotis, CEO, Cyclacel: Cyclacel is a pioneer in the field of cell cycle biology to treat cancer.

Research

Research Molecular Biology RNA Engineering

The Market for Image and Performance Enhancing Drugs (IPEDs)

Common Sense for Drug Policy Blog

JUNE 6, 2024

2014 ), and can broadly be characterised as social supply (Coomber et al. 2014 ; Begley et al. 2014 ) note that their participants overwhelmingly sourced IPEDs from ‘connected friends’, whilst Fincoeur et al. 2017 ; Greenway and Price 2018 ). Coomber et al.

Marketing

Marketing Drugs Production Pharmaceuticals

Diffusion models

Broad Institute

OCTOBER 2, 2023

Diffusion models By lcopelan@broadinstitute.org October 2, 2023 Sarah Alamdari MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2023 Spring 2023 Spring 2024 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Rates of Distress, Depression Have Doubled Among Transgender Americans Since 2014

DEA Regs Bulk Up with 2014 Anabolic Steroid Control Law Additions

Trending Sources

Trial to test monoclonal antibody for virus of growing concern

Awareness of the link between HPV and cancer has declined

Archive

Interstellar signal linked to aliens was actually just a truck

Research proves synthetic molecule can mitigate heart failure

The Moving Regulatory Landscape for Gene Therapy Trials in EU: Part 1

Lymphedema Left her 'Miserable, Depressed' Until Specialized Surgery Changed Everything

CRISPR in the Clinic

Jennifer Listgarten

TBD

Higher infant mortality rates associated with restrictive abortion laws

Have You Missed Any FDA Data Submission Requirements? A Look at Substantial Changes and New Requirements

PTC Duchenne drug approval set to be revoked in Europe

Juvenile Drug Courts

Innovative research on schistosomiasis-associated colorectal cancer (SA-CRC) yields unique insights into genetic mutations and treatment implications

Immunotherapy is here to stay

‘Ice Bucket Challenge’ funds FDA-approved ALS treatment

A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic

Alpha Missense

Viral Vectors 101: What is a Virus (and a Viral Vector)?

Postdoc flash talks

Barnacles may help reveal location of lost Malaysia Airlines flight MH370

TBD

TBD

Alpha Missense

TBD

Protein Structure Prediction (TBD)

TBD

Valid hypothesis testing after clustering

Tensor factorization (TBD)

Valid hypothesis testing after clustering

Protein Design with Deep Learning: Progress, Challenges, and Next Steps

SuFEx as a new generation of click chemistry: synthesis and development of linkers

TBD

Multimodal protein language models for deciphering protein function

More American Men Now Opting for Vasectomy

International investors abandon UK life sciences

On fitness models and the modeling of pandemic evolution

Sharing quality information on all things related to hearing: Wiki4WorldHearingDay2023

DDW Cancer Research Summit: Industry experts join the panel

The Market for Image and Performance Enhancing Drugs (IPEDs)

Diffusion models

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