2014 - Drug Discovery Digest

Rates of Distress, Depression Have Doubled Among Transgender Americans Since 2014

Drugs.com

JUNE 24, 2024

MONDAY, June 24, 2024 -- The rate of self-reported mental distress and depression among American adults who identify as transgender or gender-diverse (TGD) has more than doubled between 2014 and 2022, an analysis of federal health data.

DEA Regs Bulk Up with 2014 Anabolic Steroid Control Law Additions

FDA Law Blog: Biosimilars

AUGUST 4, 2023

Because anabolic steroids are also abused to enhance athletic performance and increase muscle strength, Congress has enacted three laws regulating anabolic steroids: the Anabolic Steroid Control Acts of 1990 and 2004, and the Designer Anabolic Steroid Control Act of 2014 (“DASCA”). DASCA became law, amending the CSA, on December 18, 2014.

Regulations

Regulations Production Clinical Trials Drugs

Awareness of the link between HPV and cancer has declined

Drug Discovery World

APRIL 17, 2023

Adjei Boakye and colleagues examined data from the Health Information National Trends Survey (HINTS) from five timepoints between 2014 (HINTS 4 cycle 4) and 2020 (HINTS 5 cycle 4). in 2014 to 27.4% in 2014 to 29.5% in 2014 to 28.4% Currently, about 54.5% In 2020, researchers found that 70.2%

Vaccine

Vaccine FDA Approval FDA Science

Scientist who discovered semaglutide to study new obesity drug

Drug Discovery World

SEPTEMBER 17, 2024

Pila Pharma was founded in Malmö, Sweden in 2014 by Dorte Gram, formerly part of the obesity research team at Novo Nordisk. The money will allow the company to study drug tolerance and the effects of the company’s molecule on obesity in a Phase IIa study.

Drugs

Drugs Regulations Disease Marketing

Community Day

Broad Institute

SEPTEMBER 30, 2024

Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

Interstellar signal linked to aliens was actually just a truck

Science Daily: Pharmacology News

MARCH 7, 2024

Sound waves thought to be from a 2014 meteor fireball north of Papua New Guinea were almost certainly vibrations from a truck rumbling along a nearby road, new research shows. The findings raise doubts that materials pulled last year from the ocean are alien materials from that meteor, as was widely reported.

Research

Research proves synthetic molecule can mitigate heart failure

Drug Discovery World

NOVEMBER 13, 2023

In parallel with our experiments, the biopharmaceutical company worked on improving the efficacy of a molecule described back in 2014, which has potential to treat cardiac diseases,” said Julio Cesar Batista Ferreira, a Professor at the Institute of Biomedical Sciences (ICB-USP).

Research

Research Laboratories Pharmaceuticals Science

Trial to test monoclonal antibody for virus of growing concern

Drug Discovery World

JULY 2, 2024

The US Centers for Disease Control and Prevention (CDC) identified increases in AFM cases in 2014, 2016, and 2018. AFM has emerged in the United States with spikes in cases every other year, primarily in the late-summer months over the last decade.

Virus

Virus Trials Clinical Trials Laboratories

Lightning Talks

Broad Institute

AUGUST 30, 2024

Lightning Talks By lcopelan@broadinstitute.org August 30, 2024 Lightning Talks MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 (..)

TBD

Broad Institute

AUGUST 28, 2024

TBD By lcopelan@broadinstitute.org August 28, 2024 TBD Brian Cleary MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

TBD

Broad Institute

AUGUST 22, 2024

TBD By lcopelan@broadinstitute.org August 22, 2024 TBD Abraham Gihawi MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

CRISPR in the Clinic

addgene Blog

NOVEMBER 2, 2023

In 2014, we wrote a blog post on CRISPR’s potential for correcting monogenetic diseases. There can be no doubt that CRISPR/Cas9 technology has been a breakthrough for the genome-editing field and the greater scientific community.

Therapies

Therapies Treatment Disease

Lymphedema Left her 'Miserable, Depressed' Until Specialized Surgery Changed Everything

Drugs.com

DECEMBER 8, 2023

8, 2023 -- Sydnee Meth survived breast cancer, but she wasn’t prepared for the aftereffects of her treatment.Doctors removed the lymph nodes from Meth’s right armpit during her second bout with breast cancer in 2014, and as a. FRIDAY, Dec.

FDA approves Niktimvo for chronic graft-versus-host disease

Drug Discovery World

AUGUST 20, 2024

The major efficacy outcome measure was overall response rate (ORR) through Cycle 7 Day 1, where overall response included complete response or partial response according to the 2014 NIH Consensus Development Project on Response Criteria. ORR was 75% in the 79 patients treated with the recommended dosage.

FDA Approval

FDA Approval FDA Disease Therapies

Microbiome

Broad Institute

AUGUST 8, 2024

Microbiome By lcopelan@broadinstitute.org August 8, 2024 Microbiome Victoria Pascal MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring (..)

Are Celebrity Suicides 'Contagious' Among Regular Folk?

Drugs.com

AUGUST 1, 2024

1, 2024 -- Celebrity suicides seem to be contagious, prompting everyday folks to consider the same, a new study suggests.The 2014 suicide death of comedian Robin Williams caused a thousand-fold increase in the risk of suicidal. THURSDAY, Aug.

Molecular dynamics

Broad Institute

AUGUST 8, 2024

Molecular dynamics By lcopelan@broadinstitute.org August 8, 2024 Molecular dynamics Ashkan Fakharzadeh Ghaan MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring (..)

Dr Gonzalez-Aseguinolaza recognised for gene therapy research

Drug Discovery World

JULY 19, 2024

Since 2014, Dr Gonzalez-Aseguinolaza has been head of the Gene Therapy Program at the Centro Investigación Médica Aplicada (CIMA), Universidad de Navarra, in Spain. She then moved into rare diseases and has been working on rare hepatic diseases for the last two decades, with a focus on the development of advanced therapies.

Therapies

Therapies Research Clinical Trials Science

Tensor factorization + single-cell rna-seq

Broad Institute

AUGUST 8, 2024

Tensor factorization + single-cell rna-seq By lcopelan@broadinstitute.org August 8, 2024 Tensor factorization + single-cell rna-seq Neriman Tokcan UMass Boston MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall (..)

RNA

Single-cell genomics + LLM or OT

Broad Institute

AUGUST 8, 2024

Single-cell genomics + LLM or OT By lcopelan@broadinstitute.org August 8, 2024 Single-cell genomics + LLM or OT David van Dijk Yale University MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 (..)

TBD

Broad Institute

AUGUST 31, 2023

TBD By lcopelan@broadinstitute.org August 31, 2023 Yuhan Hao Neptune Bio Related Resources [link] MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Higher infant mortality rates associated with restrictive abortion laws

SCIENMAG: Medicine & Health

JANUARY 17, 2024

Ann Arbor, January 17, 2024 – Contrary to professed intent, the states where abortion access was most restricted experienced the highest levels of infant mortality in the United States from 2014–2018, according to new research in the American Journal of Preventive Medicine, published by Elsevier.

Research

Jennifer Listgarten

Broad Institute

APRIL 22, 2024

From 2007 to 2017 she was at Microsoft Research, through Cambridge, MA (2014-2017), Los Angeles (2008-2014), and Redmond, WA (2007-2008). She is also a member of the steering committee for the Berkeley AI Research (BAIR) Lab. She completed her Ph.D.

Molecular Biology

Molecular Biology Engineering Science Research

Have You Missed Any FDA Data Submission Requirements? A Look at Substantial Changes and New Requirements

Cytel

JANUARY 3, 2024

Ten years ago this month, in January 2014, the FDA issued the first version of its Technical Conformance Guide (by chance I also found comments provided by my friend Jozef Aerts already complaining about the use of SAS XPORT).

FDA

FDA Packaging

Innovative research on schistosomiasis-associated colorectal cancer (SA-CRC) yields unique insights into genetic mutations and treatment implications

SCIENMAG: Medicine & Health

AUGUST 15, 2023

By utilizing whole exome sequencing on tumor tissues and their non-tumor counterparts obtained from thirty SA-CRC patients diagnosed at Changzheng Hospital from 2014 to […]

Research

Research Treatment Hospitals Disease

PTC Duchenne drug approval set to be revoked in Europe

BioPharma Drive: Drug Pricing

JANUARY 26, 2024

The EMA’s drugs committee again recommended rescinding an OK for Translarna, which was cleared in 2014 despite questions about its benefit.

Drugs

FDA gives companies leeway to go after misinformation, but not free reign

Agency IQ

JULY 12, 2024

While the policy is similar in some respects to one first created by the FDA in 2014, the latest version is considerably more detailed regarding what it will – and won’t – allow companies to do.

FDA

FDA Regulations Science Production

Juvenile Drug Courts

Common Sense for Drug Policy Blog

DECEMBER 20, 2023

Juvenile Drug Courts "As shown in Figure 13, a total of 420 JDCs were operating across the United States in 2014. Overall, between 2014 and 2021, the number of JDCs in the United States decreased by 30%." This number decreased to 305 by 2019 and again to 296 by the end of 2021.

Drugs

Drugs Treatment

‘Ice Bucket Challenge’ funds FDA-approved ALS treatment

Drug Discovery World

OCTOBER 4, 2022

million from the ALS Association, raised by the 2014 social media craze the ‘Ice Bucket Challenge’ Another 40 potential new treatments are being investigated. . In the summer of 2014, over 17 million people posted Ice Bucket Challenge videos to Facebook, including hundreds of celebrities, athletes, and politicians.

FDA Approval

FDA Approval FDA Treatment Clinical Trials

Immunotherapy is here to stay

Drug Discovery World

JULY 25, 2023

Triebel founded Immutep SA in 2001 to develop the clinical potential of LAG-3 and stayed with this company through to its acquisition by Prima BioMed in 2014. Around this time, the field of immunotherapy really broke through with the approvals of anti-CTLA-4 (ipilimumab) in 2011 and anti-PD-1 (pembrolizumab & nivolumab) in 2014.

Immune Response

Immune Response Therapies Vaccine Production

New way to synthesise bioactive compounds for drug discovery

Drug Discovery World

AUGUST 13, 2024

Following their initial discovery in 2014 and 2020, scientists have been working to produce these compounds in larger quantities for further study. “Eutyscoparol is a group of compounds whose pharmacological activity had not been thoroughly explored.

Drugs

Drugs Science Drug Development Research

How to Evaluate the Success of Anti-PD-1 Drugs In Vitro?

Crown Bioscience

JUNE 27, 2024

The phenomenal success of anti-PD-1 (programmed death-1) drugs for the treatment of cancer started in 2014 with the approvals of the monoclonal antibodies pembrolizumab (Keytruda) and nivolumab (Opdivo).

Drugs

Drugs Production Treatment

Viral Vectors 101: What is a Virus (and a Viral Vector)?

addgene Blog

AUGUST 18, 2023

Viruses are simple – a genome packaged in a protein shell (Taylor, 2014). They’re so simple that we can’t even decide if they’re alive or not. Yet these simple, small particles have quite the outsized impact – and not just on the disease front.

Virus

Virus Packaging Disease

Alpha Missense

Broad Institute

MARCH 7, 2024

Alpha Missense By lcopelan@broadinstitute.org March 7, 2024 Jun Cheng MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring (..)

Postdoc flash talks

Broad Institute

FEBRUARY 15, 2024

Postdoc flash talks By lcopelan@broadinstitute.org February 15, 2024 MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring (..)

TBD

Broad Institute

FEBRUARY 12, 2024

TBD By lcopelan@broadinstitute.org February 12, 2024 Julia Salzman MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

TBD

Broad Institute

FEBRUARY 12, 2024

TBD By lcopelan@broadinstitute.org February 12, 2024 Tavor Baharav MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

SuFEx as a new generation of click chemistry: synthesis and development of linkers

SCIENMAG: Medicine & Health

JULY 10, 2023

Based on its unique nature, Sharpless, Dong and coworkers introduced SuFEx as a new generation of click reaction in 2014 (Figure 1a). Organosulfur(VI) fluoride compounds display excellent chemical stability, and yet can efficiently realize diverse linkages via the activation of specific conditions.

Research

Barnacles may help reveal location of lost Malaysia Airlines flight MH370

Science Daily: Pharmacology News

AUGUST 23, 2023

Geoscientists have created a new method that can reconstruct the drift path and origin of debris from flight MH370, an aircraft that went missing over the Indian Ocean in 2014 with 239 passengers and crew.

Alpha Missense

Broad Institute

JANUARY 29, 2024

Alpha Missense By lcopelan@broadinstitute.org January 29, 2024 Žiga Avsec Google DeepMind MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 (..)

TBD

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Jose Alquicira-Hernandez MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Protein Structure Prediction (TBD)

Broad Institute

JANUARY 29, 2024

Protein Structure Prediction (TBD) By lcopelan@broadinstitute.org January 29, 2024 Sergey Ovchinnikov MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

TBD

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Joshua Meier MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

Rates of Distress, Depression Have Doubled Among Transgender Americans Since 2014

DEA Regs Bulk Up with 2014 Anabolic Steroid Control Law Additions

Trending Sources

Awareness of the link between HPV and cancer has declined

Archive

Scientist who discovered semaglutide to study new obesity drug

Community Day

Interstellar signal linked to aliens was actually just a truck

Research proves synthetic molecule can mitigate heart failure

Trial to test monoclonal antibody for virus of growing concern

Lightning Talks

TBD

TBD

CRISPR in the Clinic

Lymphedema Left her 'Miserable, Depressed' Until Specialized Surgery Changed Everything

FDA approves Niktimvo for chronic graft-versus-host disease

Microbiome

Are Celebrity Suicides 'Contagious' Among Regular Folk?

Molecular dynamics

Dr Gonzalez-Aseguinolaza recognised for gene therapy research

Tensor factorization + single-cell rna-seq

Single-cell genomics + LLM or OT

TBD

Higher infant mortality rates associated with restrictive abortion laws

Jennifer Listgarten

Have You Missed Any FDA Data Submission Requirements? A Look at Substantial Changes and New Requirements

Innovative research on schistosomiasis-associated colorectal cancer (SA-CRC) yields unique insights into genetic mutations and treatment implications

PTC Duchenne drug approval set to be revoked in Europe

FDA gives companies leeway to go after misinformation, but not free reign

Juvenile Drug Courts

‘Ice Bucket Challenge’ funds FDA-approved ALS treatment

Immunotherapy is here to stay

New way to synthesise bioactive compounds for drug discovery

How to Evaluate the Success of Anti-PD-1 Drugs In Vitro?

Viral Vectors 101: What is a Virus (and a Viral Vector)?

Alpha Missense

Postdoc flash talks

TBD

TBD

SuFEx as a new generation of click chemistry: synthesis and development of linkers

Barnacles may help reveal location of lost Malaysia Airlines flight MH370

Alpha Missense

TBD

Protein Structure Prediction (TBD)

TBD

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