2014 - Drug Discovery Digest

Rates of Distress, Depression Have Doubled Among Transgender Americans Since 2014

Drugs.com

JUNE 24, 2024

MONDAY, June 24, 2024 -- The rate of self-reported mental distress and depression among American adults who identify as transgender or gender-diverse (TGD) has more than doubled between 2014 and 2022, an analysis of federal health data.

NASA satellites reveal abrupt drop in global freshwater levels

Science Daily: Pharmacology News

NOVEMBER 16, 2024

The Earth's total amount of freshwater dropped abruptly starting in May 2014 and has remained low ever since. The shift could indicate Earth's continents have entered a persistently drier phase.

DEA Regs Bulk Up with 2014 Anabolic Steroid Control Law Additions

FDA Law Blog: Biosimilars

AUGUST 4, 2023

Because anabolic steroids are also abused to enhance athletic performance and increase muscle strength, Congress has enacted three laws regulating anabolic steroids: the Anabolic Steroid Control Acts of 1990 and 2004, and the Designer Anabolic Steroid Control Act of 2014 (“DASCA”). DASCA became law, amending the CSA, on December 18, 2014.

Regulations

Regulations Production Drugs Clinical Trials

Interstellar signal linked to aliens was actually just a truck

Science Daily: Pharmacology News

MARCH 7, 2024

Sound waves thought to be from a 2014 meteor fireball north of Papua New Guinea were almost certainly vibrations from a truck rumbling along a nearby road, new research shows. The findings raise doubts that materials pulled last year from the ocean are alien materials from that meteor, as was widely reported.

Research

CRISPR in the Clinic

addgene Blog

NOVEMBER 2, 2023

In 2014, we wrote a blog post on CRISPR’s potential for correcting monogenetic diseases. There can be no doubt that CRISPR/Cas9 technology has been a breakthrough for the genome-editing field and the greater scientific community.

Therapies

Therapies Treatment Disease

Lymphedema Left her 'Miserable, Depressed' Until Specialized Surgery Changed Everything

Drugs.com

DECEMBER 8, 2023

8, 2023 -- Sydnee Meth survived breast cancer, but she wasn’t prepared for the aftereffects of her treatment.Doctors removed the lymph nodes from Meth’s right armpit during her second bout with breast cancer in 2014, and as a. FRIDAY, Dec.

A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic

Broad Institute

APRIL 25, 2024

By Allessandra DiCorato April 25, 2024 As night fell on July 20th, 2014, genomicist Christian Happi was at home with his family in Lagos, Nigeria when he received a phone call he would never forget. On October 20th, 2014, as Ebola continued to spread in Guinea and in neighboring Liberia and Sierra Leone, WHO declared Nigeria free of Ebola.

Virus

Virus Hospitals Disease Government

Innovative research on schistosomiasis-associated colorectal cancer (SA-CRC) yields unique insights into genetic mutations and treatment implications

SCIENMAG: Medicine & Health

AUGUST 15, 2023

By utilizing whole exome sequencing on tumor tissues and their non-tumor counterparts obtained from thirty SA-CRC patients diagnosed at Changzheng Hospital from 2014 to […]

Research

Research Treatment Hospitals Disease

TBD

Broad Institute

AUGUST 31, 2023

TBD By lcopelan@broadinstitute.org August 31, 2023 Yuhan Hao Neptune Bio Related Resources [link] MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

PTC Duchenne drug approval set to be revoked in Europe

BioPharma Drive: Drug Pricing

JANUARY 26, 2024

The EMA’s drugs committee again recommended rescinding an OK for Translarna, which was cleared in 2014 despite questions about its benefit.

Drugs

Have You Missed Any FDA Data Submission Requirements? A Look at Substantial Changes and New Requirements

Cytel

JANUARY 3, 2024

Ten years ago this month, in January 2014, the FDA issued the first version of its Technical Conformance Guide (by chance I also found comments provided by my friend Jozef Aerts already complaining about the use of SAS XPORT).

FDA

FDA Packaging

Barnacles may help reveal location of lost Malaysia Airlines flight MH370

Science Daily: Pharmacology News

AUGUST 23, 2023

Geoscientists have created a new method that can reconstruct the drift path and origin of debris from flight MH370, an aircraft that went missing over the Indian Ocean in 2014 with 239 passengers and crew.

Sharing quality information on all things related to hearing: Wiki4WorldHearingDay2023

NIOSH Science Blog: Drugs

JUNE 7, 2023

Lack of safety and health training and language barriers are among the most frequently cited challenges companies face in promoting safety among immigrant workers (Flynn, 2014). Background The U.S. workforce is ethnically diverse. Unaddressed hearing loss is a serious and costly problem around the world.

International

SuFEx as a new generation of click chemistry: synthesis and development of linkers

SCIENMAG: Medicine & Health

JULY 10, 2023

Based on its unique nature, Sharpless, Dong and coworkers introduced SuFEx as a new generation of click reaction in 2014 (Figure 1a). Organosulfur(VI) fluoride compounds display excellent chemical stability, and yet can efficiently realize diverse linkages via the activation of specific conditions.

Research

Surveys show full scale of massive die-off of common murres following the 'warm blob' in the Pacific Ocean

Science Daily: Pharmacology News

DECEMBER 12, 2024

Colony surveys of common murres, an Alaskan seabird, show the full effects of the 2014-16 marine heat wave known as 'the blob.' Analysis of 13 colonies surveyed between 2008 and 2022 finds that colony size in the Gulf of Alaska dropped by half after the marine heat wave.

Viral Vectors 101: What is a Virus (and a Viral Vector)?

addgene Blog

AUGUST 18, 2023

Viruses are simple – a genome packaged in a protein shell (Taylor, 2014). They’re so simple that we can’t even decide if they’re alive or not. Yet these simple, small particles have quite the outsized impact – and not just on the disease front.

Virus

Virus Packaging Disease

Discovery and development of COVID?19 vaccine from laboratory to clinic

Chemical Biology and Drug Design

NOVEMBER 13, 2023

WHO proclaimed the outbreak of the Ebola virus disease (EVD), in 2014 that killed hundreds of people in West Africa. Current figures show that the epidemic had reached 216 nations, where it had killed about 6,438,926 individuals and infected 590,405,710.

Vaccine

Vaccine Laboratories RNA Clinical Development

New parasite discovered amid decline of California's unique Channel Island fox

Science Daily: Pharmacology News

OCTOBER 23, 2024

A recovery program increased their population by 2010, but from 2014 to 2018, it fell to 30% of its peak due to a new acanthocephalan parasite, exacerbated by a prolonged drought. In the 1990s, the San Miguel Island fox nearly went extinct, with numbers dropping to just 15.

Research

Tripling in proportion of smokers’ duty free tobacco purchases in England since 2019

SCIENMAG: Medicine & Health

JULY 18, 2023

Between 2002 and 2014, between 12% and 20% of UK adult smokers […]

Marketing

The science of ageing and restoring healthspan

Drug Target Review

JANUARY 8, 2024

acquired by Teva Pharmaceuticals in 2014. Before that, he served as president and CEO of AgeneBio, Inc., a clinical-stage private biopharma company developing therapies for neurological and psychiatric diseases. Earlier, he held the role of senior vice president & chief commercial officer at NuPathe Inc.,

Science

Science Disease FDA Approval Clinical Trials

More American Men Now Opting for Vasectomy

Drugs.com

AUGUST 31, 2023

vasectomy rate increased by 26% between 2014 and 2021, THURSDAY, Aug. 31, 2023 -- Vasectomies are becoming more common in the United States, with rates surging by more than one-quarter during the past decade, a recent study reveals.

FDA gives companies leeway to go after misinformation, but not free reign

Agency IQ

JULY 12, 2024

While the policy is similar in some respects to one first created by the FDA in 2014, the latest version is considerably more detailed regarding what it will – and won’t – allow companies to do.

FDA

FDA Regulations Science Production

Largest-ever genetic study of epilepsy finds possible therapeutic targets

Broad Institute

OCTOBER 3, 2024

Ultra-rare variants Since 2014, Epi25 has collected information from patients with multiple types of epilepsy, including a severe group of epilepsies known as developmental and epileptic encephalopathies as well as more common and milder forms called genetic generalized epilepsy and non-acquired focal epilepsy (NAFE).

DNA

DNA Doctors Treatment Disease

Juvenile Drug Courts

Common Sense for Drug Policy Blog

DECEMBER 20, 2023

Juvenile Drug Courts "As shown in Figure 13, a total of 420 JDCs were operating across the United States in 2014. Overall, between 2014 and 2021, the number of JDCs in the United States decreased by 30%." This number decreased to 305 by 2019 and again to 296 by the end of 2021.

Drugs

Drugs Treatment

Are Celebrity Suicides 'Contagious' Among Regular Folk?

Drugs.com

AUGUST 1, 2024

1, 2024 -- Celebrity suicides seem to be contagious, prompting everyday folks to consider the same, a new study suggests.The 2014 suicide death of comedian Robin Williams caused a thousand-fold increase in the risk of suicidal. THURSDAY, Aug.

From GRP to SIUU – the Evolution of FDA Guidance on Off-Label Dissemination of Scientific Information

FDA Law Blog: Biosimilars

OCTOBER 24, 2023

Previous iterations of this guidance from 2009 and 2014 (blogged on here and here ) were known as Good Reprint Practices (GRP). The SIUU Guidance, which supersedes the 2014 Draft GRP Guidance, is not substantially different in that regard and contains similar information as to the types of disclosures previously recommended.

FDA

FDA Clinical Trials Trials Government

Xylazine in the Unregulated Drug Supply

Common Sense for Drug Policy Blog

OCTOBER 21, 2024

2014 ; Forrester, 2016 ), it was first described as a more prevalent additive in the unregulated drug supply of Puerto Rico ( Reyes et al., Xylazine in the Unregulated Drug Supply "Xylazine is a veterinary tranquilizer, which is not approved for human use in the United States, but is commonly used for sedating large animals ( Reyes et al.,

Drugs

How to Evaluate the Success of Anti-PD-1 Drugs In Vitro?

Crown Bioscience

JUNE 27, 2024

The phenomenal success of anti-PD-1 (programmed death-1) drugs for the treatment of cancer started in 2014 with the approvals of the monoclonal antibodies pembrolizumab (Keytruda) and nivolumab (Opdivo).

Drugs

Drugs Treatment Production

Biotech Venture Ecosystem: Quick Health Check

LifeSciVC

JANUARY 12, 2024

With a little over 50 new startups raising capital in 4Q24, we’re back to levels not seen for nearly a decade, at the start of the biotech secular bull market in 2013-2014.

Marketing

Marketing Science

Employee Spotlight - Co-ops

Cyclica

APRIL 28, 2023

That’s why, since 2014, Cyclica has provided University of Waterloo (UofW) students the opportunity to gain valuable work experience through a collaboration with the UofW’s’ co-op program. At Cyclica, we believe in giving back to the community and providing educational opportunities for the next generation.

Large Language Models and Biological Foundation Models

Broad Institute

OCTOBER 11, 2024

Large Language Models and Biological Foundation Models By lcopelan@broadinstitute.org October 11, 2024 Large Language Models and Biological Foundation Models Syed Rizvi Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

Lightning Talks

Broad Institute

AUGUST 30, 2024

Lightning Talks By lcopelan@broadinstitute.org August 30, 2024 Lightning Talks MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 (..)

TBD

Broad Institute

AUGUST 28, 2024

TBD By lcopelan@broadinstitute.org August 28, 2024 TBD Brian Cleary MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

TBD

Broad Institute

AUGUST 22, 2024

TBD By lcopelan@broadinstitute.org August 22, 2024 TBD Abraham Gihawi MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Microbiome

Broad Institute

AUGUST 8, 2024

Microbiome By lcopelan@broadinstitute.org August 8, 2024 Microbiome Victoria Pascal MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring (..)

Alpha Missense

Broad Institute

MARCH 7, 2024

Alpha Missense By lcopelan@broadinstitute.org March 7, 2024 Jun Cheng MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring (..)

Postdoc flash talks

Broad Institute

FEBRUARY 15, 2024

Postdoc flash talks By lcopelan@broadinstitute.org February 15, 2024 MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring (..)

TBD

Broad Institute

FEBRUARY 12, 2024

TBD By lcopelan@broadinstitute.org February 12, 2024 Julia Salzman MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

TBD

Broad Institute

FEBRUARY 12, 2024

TBD By lcopelan@broadinstitute.org February 12, 2024 Tavor Baharav MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

Alpha Missense

Broad Institute

JANUARY 29, 2024

Alpha Missense By lcopelan@broadinstitute.org January 29, 2024 Žiga Avsec Google DeepMind MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 (..)

TBD

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Jose Alquicira-Hernandez MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Protein Structure Prediction (TBD)

Broad Institute

JANUARY 29, 2024

Protein Structure Prediction (TBD) By lcopelan@broadinstitute.org January 29, 2024 Sergey Ovchinnikov MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

TBD

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Joshua Meier MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

Molecular dynamics

Broad Institute

AUGUST 8, 2024

Molecular dynamics By lcopelan@broadinstitute.org August 8, 2024 Molecular dynamics Ashkan Fakharzadeh Ghaan MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring (..)

Rates of Distress, Depression Have Doubled Among Transgender Americans Since 2014

NASA satellites reveal abrupt drop in global freshwater levels

Trending Sources

DEA Regs Bulk Up with 2014 Anabolic Steroid Control Law Additions

Interstellar signal linked to aliens was actually just a truck

CRISPR in the Clinic

Lymphedema Left her 'Miserable, Depressed' Until Specialized Surgery Changed Everything

A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic

Innovative research on schistosomiasis-associated colorectal cancer (SA-CRC) yields unique insights into genetic mutations and treatment implications

TBD

PTC Duchenne drug approval set to be revoked in Europe

Have You Missed Any FDA Data Submission Requirements? A Look at Substantial Changes and New Requirements

Barnacles may help reveal location of lost Malaysia Airlines flight MH370

Sharing quality information on all things related to hearing: Wiki4WorldHearingDay2023

SuFEx as a new generation of click chemistry: synthesis and development of linkers

Surveys show full scale of massive die-off of common murres following the 'warm blob' in the Pacific Ocean

Viral Vectors 101: What is a Virus (and a Viral Vector)?

Discovery and development of COVID?19 vaccine from laboratory to clinic

New parasite discovered amid decline of California's unique Channel Island fox

Tripling in proportion of smokers’ duty free tobacco purchases in England since 2019

The science of ageing and restoring healthspan

More American Men Now Opting for Vasectomy

FDA gives companies leeway to go after misinformation, but not free reign

Largest-ever genetic study of epilepsy finds possible therapeutic targets

Juvenile Drug Courts

Are Celebrity Suicides 'Contagious' Among Regular Folk?

From GRP to SIUU – the Evolution of FDA Guidance on Off-Label Dissemination of Scientific Information

Xylazine in the Unregulated Drug Supply

How to Evaluate the Success of Anti-PD-1 Drugs In Vitro?

Biotech Venture Ecosystem: Quick Health Check

Employee Spotlight - Co-ops

Large Language Models and Biological Foundation Models

Lightning Talks

TBD

TBD

Microbiome

Alpha Missense

Postdoc flash talks

TBD

TBD

Alpha Missense

TBD

Protein Structure Prediction (TBD)

TBD

Molecular dynamics

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