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Cancer immunotherapy: GDF-15’s role in Anti-PD-1 resistance

Drug Target Review

Prior to joining CatalYm, Christine co-founded Rigontec in 2014 where she led the company’s discovery and non-clinical development activities as Senior Vice President, Research. Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration. Current Opinion in Cell Biology.

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Biomarkers: A Novel Approach to Understanding Dementia

PerkinElmer

1 To address the urgent need for new therapies, the UK’s Medical Research Council (MRC), a national public agency supporting health science and research, established the Dementias Platform United Kingdom (DPUK) in 2014. Unless something is done, experts predict these numbers will likely double within the next 20 years.

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Women in Stem with Vicky Marsh Durban

Drug Target Review

I don’t think that it’s harder for women to enter careers in STEM, at least not in the scientific field—cell biology—that I have predominantly worked in. She returned to Cardiff in 2014 for a Research Fellowship at the European Cancer Stem Cell Research Institute.

Doctors 58
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Fighting Parasitic Infections: Promise in Cyclic Peptides

NIH Director's Blog: Drug Discovery

2014 Jan 9;8(1):e2628. [2] References : [1] Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens. Crowther GJ, Booker ML, He M, Li T, Raverdy S, Novelli JF, He P, Dale NR, Fife AM, Barker RH Jr, Kramer ML, Van Voorhis WC, Carlow CK, Wang MW. PLoS Negl Trop Dis.

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CAR-NK cells: promising for cancer therapy

Drug Target Review

Professor Alan Trounson AO CEO, Executive Director, Cartherics Alan is the past President of the Californian Institute for Regenerative Medicine (2007-2014), the Californian state’s $3 billion stem cell agency driving research in stem cell biology and facilitating the translation of stem cell discoveries into clinical therapies.

Therapies 117
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A research team searches for every gene that helps tumors evade immunotherapy

Broad Institute

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. They are used to treat cancers including melanoma and non-small cell lung cancer, but work only for a small fraction of patients.

Research 137
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Transforming high-throughput screening with mass spectrometry

Drug Discovery World

However, despite this long list of features that makes MALDI-TOF MS suitable for drug screening, it was not until 2014 that the first study detailing its use in a high-throughput assay was published. Xia, in Encyclopedia of Toxicology (3rd edition), Elsevier, 2014. References . Attene-Ramos and M. Elsen and J.D. Kelly, N.T.