2014 Metabolic Stability Pharmacokinetics Research 
Metabolite Tales Blog
DECEMBER 13, 2023
To curb glucuronidation at that position a gem-dimethyl group was incorporated which not only boosted metabolic stability, but also resulted in increased potency of the final lead compound. Paine and Aleksandra Galetin (2014). Drug Metabolism and Disposition 42 (4) 650-664; [link]. [2] Polli, Mary F. J Pharm Biomed Anal.
Molecular Design
MAY 11, 2019
The heavy citation and wide acceptance of Ro5 provided incentives for researchers to publish their own respective analyses of large (usually proprietary) data sets and this has been expressed more succinctly as “Ro5 envy”. So let's take a look at YL2018 and the trajectories.
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