2014 Metabolic Stability Process Chemistry Trials 
Metabolite Tales Blog
JULY 5, 2023
Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. link] [4] Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry.
Metabolite Tales Blog
JULY 5, 2023
Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. link] [4] Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry.
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