2014, Metabolic Stability and Small Molecule

N-glucuronidation: the human element

Metabolite Tales Blog

DECEMBER 13, 2023

N -glucuronidation: the human element By Julia Shanu-Wilson In our last blog of the year, we look at why N -glucuronidation of drugs is important in human drug metabolism. Glucuronidation is the most common phase II reaction observed in the metabolism of drugs in humans. Paine and Aleksandra Galetin (2014). Polli, Mary F.

Small Molecule

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Obstacles and innovations of macrocyclic drug development

Drug Target Review

JANUARY 16, 2025

Traditionally, drug discovery has focused on small-molecule therapeutics, typically with a molecular weight of less than 500 Daltons. 2 Typically, small-molecule drugs target active sites buried inside proteins. What are macrocycles and why are they interesting for drug discovery?

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Drug Discovery Digest

N-glucuronidation: the human element

Obstacles and innovations of macrocyclic drug development

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