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Metabolism of macrocyclic drugs

Metabolite Tales Blog

Current macrocycles in clinical use generally focus on treatment of infectious diseases, cancer and auto-immune disorders. Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed.

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Metabolism of de novo designed macrocyclic drugs

Metabolite Tales Blog

Current macrocycles in clinical use generally focus on treatment of infectious diseases, cancer and auto-immune disorders. Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed.