Metabolism of macrocyclic drugs
Metabolite Tales Blog
JULY 5, 2023
Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. 20 (March 20, 2014). Ayushi Jain and Khalid Mumtaz, 2022. Avicenna J Med 12:154–156.
Let's personalize your content