Broad Institute

APRIL 25, 2024

By Allessandra DiCorato April 25, 2024 As night fell on July 20th, 2014, genomicist Christian Happi was at home with his family in Lagos, Nigeria when he received a phone call he would never forget. On October 20th, 2014, as Ebola continued to spread in Guinea and in neighboring Liberia and Sierra Leone, WHO declared Nigeria free of Ebola.

Virus 132

Virus Hospitals Disease Government 132

Drug Target Review

MAY 22, 2024

In parallel, we are exploring the technical performance of circVec in other viral vectors, as well as non-viral approaches which we expect will surpass virus-based vector-format as the state-of-the-art solutions for gene therapy in the future. So far, we have successfully expressed circRNA from six different vector types.

Therapies 59

Therapies RNA Protein Expression DNA 59

The Pharma Data

NOVEMBER 19, 2020

The program is being led by Sosei Heptares and progressed in collaboration with multiple companies including Syngene International, Domainex, Fidelta, o2h Discovery, Piramal, WuXi AppTec and the MRC Laboratory of Molecular Biology. 2014), 281, 4085-4096. References. Hilgenfeld, Febs J. Pillaiyar, et al, J. 2016), 59, 6595-6628.

Small Molecule 40

Small Molecule Structure Based Drug Design (SBDD) International Molecular Biology 40

Codon

JUNE 13, 2024

But those studies were criticized in 2014 when researchers claimed that the earlier methods used “a rough biochemical approach…now considered to be unreliable for accurate genome size determinations.” The HK97 virus, for example, infects E. The New Caledonian fork fern has clearly found a solution to this problem.

DNA 60

DNA Molecular Biology Virus International 60

Codon

JUNE 25, 2024

A molecular model showing FtsZ proteins (in green and red), extracted from a microbe called Staphylococcus aureus , constricting a liposome (blue). eLife (2014). The researchers chose to discard genes that encode virus-sensing machinery because the cells would be grown in a sterile laboratory environment. Credit: Szwedziak P.

DNA 70

DNA RNA Laboratories Engineering 70

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. ” The tool was crafted with a virus, called GIL16.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. ” The tool was crafted with a virus, called GIL16.

Therapies 52

Therapies RNA DNA Engineering 52