2015 - Drug Discovery Digest

'Better than graphene' material development may improve implantable technology

Science Daily: Pharmacology News

MAY 7, 2024

Borophene, the atomically thin version of boron first synthesized in 2015, is more conductive, thinner, lighter, stronger and more flexible than graphene, the 2D version of carbon. Move over, graphene. There's a new, improved two-dimensional material in the lab.

Research

German Patient is 7th Person Probably Cured of HIV

Drugs.com

JULY 19, 2024

FRIDAY, July 19, 2024 -- A German man has become the seventh person to apparently be cured of HIV, researchers report.The 60-year-old man, referred to as the “next Berlin Patient,” was treated with a stem cell transplant in October 2015 for acute my.

Research

Climate scientists express their views on possible future climate scenarios in a new study

Science Daily: Pharmacology News

OCTOBER 1, 2024

A new survey of climate experts reveals that a majority believes the Earth to be headed for a rise in global temperatures far higher than the 2015 Paris Agreement targets of 1.5 to well-below 2 degrees Celsius.

Steady Rise in U.S. Cases of Tick-Borne Babesiosis Disease

Drugs.com

OCTOBER 9, 2024

9, 2024 -- Cases of a tick-borne parasitic disease have steadily increased in recent years, a new study shows.Rates of babesiosis increased an average 9% a year in the United States between 2015 and 2022, researchers reported in. WEDNESDAY, Oct.

Disease

Disease Research

Feng Zhang awarded the National Medal of Technology and Innovation

Broad Institute

JANUARY 6, 2025

In 2023, the first CRISPR Cas9-based therapeutic, which is based on a design Zhang developed in 2015, was approved for clinical use to treat sickle cell disease. This and other molecular tools developed by Zhang have accelerated biomedical research worldwide. Lisa Yang and Hock E.

Medical Schools

Medical Schools Engineering Science Hospitals

Rates of a tick-borne parasitic disease are on the rise

Science Daily: Pharmacology News

OCTOBER 8, 2024

Rates of babesiosis, a tick-borne parasitic disease, increased an average of 9% per year in the United States between 2015 and 2022 and four in 10 patients were found to be co-infected with another tick-borne illness such as Lyme disease, according to a new study.

Disease

Homeless Americans' Death Rate Rises on Hot Days

Drugs.com

OCTOBER 15, 2024

15, 2024 -- As temperatures soar in some of America's hottest spots, death rates among local homeless people rise as well, new research shows.Data from 2015 through 2022 finds a big bump in deaths among unhoused people in Clark County. TUESDAY, Oct.

Research

Remote learning during pandemic aids medical students with disabilities

SCIENMAG: Medicine & Health

AUGUST 18, 2023

The proportion of students reporting attention deficit hyperactivity disorder or chronic health and/or psychological disabilities has increased between 2015 and 2021. Medical students who reported a disability to their school increased by more than 25% during the COVID-19 pandemic, a study shows.

TBD

Broad Institute

AUGUST 31, 2023

TBD By lcopelan@broadinstitute.org August 31, 2023 Yuhan Hao Neptune Bio Related Resources [link] MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Researchers advance ‘placenta-on-a-chip’ with sensing, imaging technology

SCIENMAG: Medicine & Health

NOVEMBER 28, 2023

9, 2015, hangs just outside Nicole Hashemi’s Iowa State University laboratory. AMES, Iowa – A research poster dated Dec. It introduces a major project for Hashemi and her research group. And it’s evidence that scientific persistence sometimes equals scientific advancement. Credit: Photo by Christopher Gannon/Iowa State University.

Research

Research Laboratories

From Bench to Bedside and Back Again: Strategies for Effectively Leveraging Pre-Clinical Data to Accelerate R&D

Fierce BioTech

JULY 17, 2023

As recently as 2015, researchers concluded that anywhere from 50-80% of pre-clinical animal (in vivo) research data was irreproducible,1 representing a monetary loss of more than $28 billion. PLOS Biology 13(6): e1002165.

Clinical Trials

Clinical Trials Drug Development Research Trials

A comprehensive review on the research progress of PTP1B inhibitors as antidiabetics

Chemical Biology and Drug Design

MAY 25, 2023

In this review, we have compiled a summary of the most recent advances in synthetic PTP1B inhibitors from 2015 to 2022 which have scope to be developed as clinical antidiabetic drugs. PTP1B inhibitors also restore leptin signaling and are considered a potential obesity target.

Research

Research Regulations Drugs

Getting to Know Expansion Microscopy

addgene Blog

JUNE 20, 2023

Since its introduction in 2015 by the Boyden Lab , ExM has been steadily growing in popularity with an abundance of protocols and examples of applications from across disciplines now available.

Mothers need more “exclusive breastfeeding” support

SCIENMAG: Medicine & Health

DECEMBER 8, 2023

According to the World Health Organization (WHO), between 2015 and 2021, 48% of mothers exclusively breastfed, meaning that their babies were not given any other food or liquids. Exclusive breastfeeding for the first six months of life is proven to protect both mother and child health.

Significant “post-COVID” resurgence in invasive meningococcal disease

SCIENMAG: Medicine & Health

NOVEMBER 17, 2023

A team of scientists from the Institut Pasteur has used the database of the National Reference Center for Meningococci to trace the evolution of invasive meningococcal disease cases in France between 2015 and 2022, revealing an unprecedented resurgence in the disease after the easing of control measures imposed during the COVID-19 epidemic.

Disease

Unveiling the origins of merging black holes in galaxies like our own

Science Daily: Pharmacology News

JUNE 29, 2023

The groundbreaking detection of gravitational waves in 2015, caused by the coalescence of two black holes, opened a new window into the universe. Black holes, some of the most captivating entities in the cosmos, possess an immense gravitational pull so strong that not even light can escape.

Protein offers promise for treatment of reproductive conditions

Drug Target Review

OCTOBER 25, 2023

2015 March 3 [2022 December 15]; 2015(8):7-12. This research was published in JCI Insight. References 1 English FA, Kenny LC, McCarthy FP. Risk factors and effective management of preeclampsia. Dovepress [Internet]. Available from: [link]

Treatment

Treatment Virus Research Science

Medical royal colleges receive millions from drug and medical devices companies

SCIENMAG: Medicine & Health

JULY 26, 2023

Royal colleges in the UK have received more than £9 million in marketing payments from drug and medical devices companies since 2015, but do not always disclose the payments publicly, finds an investigation published by The BMJ today.

Drugs

Drugs Marketing

The 340B Program Climbed to $44 Billion in 2021—With Hospitals Grabbing Most of the Money (rerun)

Drug Channels

DECEMBER 16, 2022

Fortunately, my 2022 FOIA efforts (described below) extracted purchases by 340B covered entity type for 2015 through 2021. Shortly after I published the article below, HRSA posted public data about 340B covered entity purchases on its website. Alas, HRSA neglected to post any historical data.

Hospitals

Hospitals Drugs Pharmacy

Blogger Meets Blogger

Molecular Design

JULY 26, 2023

The odds against such an encounter would appear to be overwhelming since Ash lives in California while this was my first visit to the USA since 2015. Ash and I have actually known each other for about 15 years but we’d never before met in real life.

Stop the Presses! DEA and DOJ Fine eBay for not Reporting Sales of Tableting and Pill Press Machines

FDA Law Blog: Biosimilars

FEBRUARY 7, 2024

According to the eBay settlement agreement, the government contends that from October 2015 to the present, eBay did not comply with any of “the CSA’s reporting and recordkeeping obligations” involving thousands of transactions. Also, a DEA Form 452 report must be electronically filed within 15 days after the order is shipped.

Regulations

Regulations Compliance Government Production

Delaying methane mitigation increases risk of breaching Paris Agreement climate goal, study finds

SCIENMAG: Medicine & Health

JULY 26, 2023

A key element of the 2015 Paris Agreement, a legally binding international treaty on climate change, is the commitment to limit average global temperatures increases to well below […]

International

International Research

AI in gene delivery vector discovery and design

Drug Target Review

OCTOBER 26, 2023

Subsequent roles at the Institute of Cancer Research and The Scripps Research Institute solidified his expertise in protein design and vaccine development, leading to the 2015 Scripps CHAVI-ID Young Investigator Award. Nature Communications 6 , 6246 (2015). Nature Biotechnology 34 , 204-209 (2016). Münch RC, et al. Münch RC, et al.

Engineering

Engineering Virus Therapies Immune Response

The power of combinations in blood cancers

Drug Target Review

NOVEMBER 6, 2023

2015);126(1):9-16. 2015);126(4):454-462. Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. Strati P, Shanafelt TD. Monoclonal B-cell lymphocytosis and early-stage chronic lymphocytic leukemia: diagnosis, natural history, and risk stratification.

Small Molecule

Small Molecule Therapies Treatment Disease

Need To Conduct a Multi-Variable Study? REPROCELL Can Help with That!

Reprocell

JULY 18, 2024

In April 2015, the 106 th annual meeting of the American Association for Cancer Research was held in Philadelphia, Pennsylvania. REPROCELL USA was in attendance and submitted a poster titled , Family History of Cancer in First-degree Relatives and Increased Cancer Risk: A Multinational Study.

Research

Older Black Men Are Disproportionately Affected by the Overdose Crisis

National Institute on Drug Abuse: Nora's Blog

AUGUST 28, 2024

A NIDA analysis found that between 2015 and 2023 (provisional data), there was a nearly 5-fold increase in overdose deaths among non-Hispanic Black men 55 and older (figure). In 2023, deaths in that demographic category were nearly triple the national average for that age group.

Treatment

Treatment Research Disease Drugs

Midwest Integrated Center for Computational Materials renewed by U.S. Department of Energy

SCIENMAG: Medicine & Health

AUGUST 7, 2023

Founded in 2015, the Center is headquartered at DOE’s Argonne National Laboratory. Department of Energy (DOE) has announced the renewal of the Midwest Integrated Center for Computational Materials (MICCoM) for another three years at $3 million per year.

Laboratories

Swiss startup LimmaTech licenses GSK vaccine, hires ex-CureVac chief as CEO

BioPharma Drive: Drug Pricing

JULY 20, 2023

The startup will take on development of a shigellosis vaccine GSK inherited when it acquired LimmaTech’s predecessor, GlycoVaxyn, in 2015.

Vaccine

Vaccine Licensing Licensing

Large Language Models and Biological Foundation Models

Broad Institute

OCTOBER 11, 2024

Large Language Models and Biological Foundation Models By lcopelan@broadinstitute.org October 11, 2024 Large Language Models and Biological Foundation Models Syed Rizvi Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

Lightning Talks

Broad Institute

AUGUST 30, 2024

Lightning Talks By lcopelan@broadinstitute.org August 30, 2024 Lightning Talks MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 (..)

TBD

Broad Institute

AUGUST 28, 2024

TBD By lcopelan@broadinstitute.org August 28, 2024 TBD Brian Cleary MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

TBD

Broad Institute

AUGUST 22, 2024

TBD By lcopelan@broadinstitute.org August 22, 2024 TBD Abraham Gihawi MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Microbiome

Broad Institute

AUGUST 8, 2024

Microbiome By lcopelan@broadinstitute.org August 8, 2024 Microbiome Victoria Pascal MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring (..)

Alpha Missense

Broad Institute

MARCH 7, 2024

Alpha Missense By lcopelan@broadinstitute.org March 7, 2024 Jun Cheng MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring (..)

Postdoc flash talks

Broad Institute

FEBRUARY 15, 2024

Postdoc flash talks By lcopelan@broadinstitute.org February 15, 2024 MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring (..)

TBD

Broad Institute

FEBRUARY 12, 2024

TBD By lcopelan@broadinstitute.org February 12, 2024 Julia Salzman MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

TBD

Broad Institute

FEBRUARY 12, 2024

TBD By lcopelan@broadinstitute.org February 12, 2024 Tavor Baharav MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

Alpha Missense

Broad Institute

JANUARY 29, 2024

Alpha Missense By lcopelan@broadinstitute.org January 29, 2024 Žiga Avsec Google DeepMind MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 (..)

TBD

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Jose Alquicira-Hernandez MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Protein Structure Prediction (TBD)

Broad Institute

JANUARY 29, 2024

Protein Structure Prediction (TBD) By lcopelan@broadinstitute.org January 29, 2024 Sergey Ovchinnikov MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

TBD

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Joshua Meier MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

Molecular dynamics

Broad Institute

AUGUST 8, 2024

Molecular dynamics By lcopelan@broadinstitute.org August 8, 2024 Molecular dynamics Ashkan Fakharzadeh Ghaan MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring (..)

Valid hypothesis testing after clustering

Broad Institute

JANUARY 29, 2024

Valid hypothesis testing after clustering By lcopelan@broadinstitute.org January 29, 2024 Yiqun Chen MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

Tensor factorization (TBD)

Broad Institute

JANUARY 29, 2024

Tensor factorization (TBD) By lcopelan@broadinstitute.org January 29, 2024 Neriman Tokcan UMass Boston MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall (..)

'Better than graphene' material development may improve implantable technology

German Patient is 7th Person Probably Cured of HIV

Trending Sources

Climate scientists express their views on possible future climate scenarios in a new study

Steady Rise in U.S. Cases of Tick-Borne Babesiosis Disease

Feng Zhang awarded the National Medal of Technology and Innovation

Rates of a tick-borne parasitic disease are on the rise

Homeless Americans' Death Rate Rises on Hot Days

Remote learning during pandemic aids medical students with disabilities

TBD

Researchers advance ‘placenta-on-a-chip’ with sensing, imaging technology

From Bench to Bedside and Back Again: Strategies for Effectively Leveraging Pre-Clinical Data to Accelerate R&D

A comprehensive review on the research progress of PTP1B inhibitors as antidiabetics

Getting to Know Expansion Microscopy

Mothers need more “exclusive breastfeeding” support

Significant “post-COVID” resurgence in invasive meningococcal disease

Unveiling the origins of merging black holes in galaxies like our own

Protein offers promise for treatment of reproductive conditions

Medical royal colleges receive millions from drug and medical devices companies

The 340B Program Climbed to $44 Billion in 2021—With Hospitals Grabbing Most of the Money (rerun)

Blogger Meets Blogger

Stop the Presses! DEA and DOJ Fine eBay for not Reporting Sales of Tableting and Pill Press Machines

Delaying methane mitigation increases risk of breaching Paris Agreement climate goal, study finds

AI in gene delivery vector discovery and design

The power of combinations in blood cancers

Need To Conduct a Multi-Variable Study? REPROCELL Can Help with That!

Older Black Men Are Disproportionately Affected by the Overdose Crisis

Midwest Integrated Center for Computational Materials renewed by U.S. Department of Energy

Swiss startup LimmaTech licenses GSK vaccine, hires ex-CureVac chief as CEO

Large Language Models and Biological Foundation Models

Lightning Talks

TBD

TBD

Microbiome

Alpha Missense

Postdoc flash talks

TBD

TBD

Alpha Missense

TBD

Protein Structure Prediction (TBD)

TBD

Molecular dynamics

Valid hypothesis testing after clustering

Tensor factorization (TBD)

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