2015 - Drug Discovery Digest

Rate of Cancer in Teens, Young Adults Increased From 1973 to 2015

The Pharma Data

DECEMBER 2, 2020

2, 2020 — In adolescents and young adults (AYAs), cancer has a unique epidemiological pattern and is a growing concern, with an increased rate of cancer from 1973 to 2015, according to a study published online Dec. The study included 497,452 AYAs diagnosed with cancer from 1973 to 2015. WEDNESDAY, Dec. 1 in JAMA Network Open.

Research

Happy New Year … and a Look Back at a Memorable 2015

NIH Director's Blog: Drug Development

JANUARY 5, 2016

But before diving into our first “new science” post of 2016, let’s take a quick look back at 2015 and some of its remarkable accomplishments. Four of 2015’s Top 10 featured developments directly benefited from NIH support—including Science’s “Breakthrough of the Year,” the CRISPR/Cas9 gene-editing technique. Protein Cell.

Vaccine

Vaccine Science Engineering Disease

Climate scientists express their views on possible future climate scenarios in a new study

Science Daily: Pharmacology News

OCTOBER 1, 2024

A new survey of climate experts reveals that a majority believes the Earth to be headed for a rise in global temperatures far higher than the 2015 Paris Agreement targets of 1.5 to well-below 2 degrees Celsius.

Community Day

Broad Institute

SEPTEMBER 30, 2024

Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

German Patient is 7th Person Probably Cured of HIV

Drugs.com

JULY 19, 2024

FRIDAY, July 19, 2024 -- A German man has become the seventh person to apparently be cured of HIV, researchers report.The 60-year-old man, referred to as the “next Berlin Patient,” was treated with a stem cell transplant in October 2015 for acute my.

Research

Nalmefene vs Naloxone

Common Sense for Drug Policy Blog

OCTOBER 1, 2024

2022 ; Neale & Strang, 2015 ) Providers may find it difficult to manage withdrawal symptoms and comorbidities like chronic pain, forcing the patient to suffer until the reversal agent wears off. Bennett et al., 2020 ; Hill et al.,

FDA Approval

FDA Approval FDA Marketing Research

'Better than graphene' material development may improve implantable technology

Science Daily: Pharmacology News

MAY 7, 2024

Borophene, the atomically thin version of boron first synthesized in 2015, is more conductive, thinner, lighter, stronger and more flexible than graphene, the 2D version of carbon. Move over, graphene. There's a new, improved two-dimensional material in the lab.

Research

Lightning Talks

Broad Institute

AUGUST 30, 2024

Lightning Talks By lcopelan@broadinstitute.org August 30, 2024 Lightning Talks MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 (..)

TBD

Broad Institute

AUGUST 28, 2024

TBD By lcopelan@broadinstitute.org August 28, 2024 TBD Brian Cleary MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

TBD

Broad Institute

AUGUST 22, 2024

TBD By lcopelan@broadinstitute.org August 22, 2024 TBD Abraham Gihawi MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Microbiome

Broad Institute

AUGUST 8, 2024

Microbiome By lcopelan@broadinstitute.org August 8, 2024 Microbiome Victoria Pascal MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring (..)

Melting of Alaskan glaciers accelerating faster than previously thought

Science Daily: Pharmacology News

JULY 2, 2024

In particular, they found that icefield-wide, rates of glacier area shrinkage were five times faster from 2015-2019 relative to 1948-1979. The team looked at records going back to 1770 and identified three distinct periods in how icefield volume changed.

Research

Molecular dynamics

Broad Institute

AUGUST 8, 2024

Molecular dynamics By lcopelan@broadinstitute.org August 8, 2024 Molecular dynamics Ashkan Fakharzadeh Ghaan MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring (..)

Novartis, Pfizer, Otsuka and Novo breach the ABPI Code

Drug Discovery World

JULY 8, 2024

Otsuka’s reproof related to a previous 2015 case, as it reportedly failed to disclose relevant information, and because interviewees had not been given the opportunity to agree and sign the witness statements produced as a record of their interviews and submitted to the PMCPA.

Pharmaceuticals

Pharmaceuticals Vaccine Drugs

Tensor factorization + single-cell rna-seq

Broad Institute

AUGUST 8, 2024

Tensor factorization + single-cell rna-seq By lcopelan@broadinstitute.org August 8, 2024 Tensor factorization + single-cell rna-seq Neriman Tokcan UMass Boston MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall (..)

RNA

Single-cell genomics + LLM or OT

Broad Institute

AUGUST 8, 2024

Single-cell genomics + LLM or OT By lcopelan@broadinstitute.org August 8, 2024 Single-cell genomics + LLM or OT David van Dijk Yale University MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 (..)

mPTP Inhibitors block mitochondrial dysfunction in ALS

Drug Discovery World

SEPTEMBER 9, 2024

Mouse model that mimics ALS symptoms Biospective has implemented a modified, slower progressing version of the TDP-43 NLS8 (or DELTA-NLS) mouse model that was originally developed at the University of Pennsylvania (Walker et al.,

Small Molecule

Small Molecule Clinical Trials Disease Trials

TBD

Broad Institute

AUGUST 31, 2023

TBD By lcopelan@broadinstitute.org August 31, 2023 Yuhan Hao Neptune Bio Related Resources [link] MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Need To Conduct a Multi-Variable Study? REPROCELL Can Help with That!

Reprocell

JULY 18, 2024

In April 2015, the 106 th annual meeting of the American Association for Cancer Research was held in Philadelphia, Pennsylvania. REPROCELL USA was in attendance and submitted a poster titled , Family History of Cancer in First-degree Relatives and Increased Cancer Risk: A Multinational Study.

Research

Researchers advance ‘placenta-on-a-chip’ with sensing, imaging technology

SCIENMAG: Medicine & Health

NOVEMBER 28, 2023

9, 2015, hangs just outside Nicole Hashemi’s Iowa State University laboratory. AMES, Iowa – A research poster dated Dec. It introduces a major project for Hashemi and her research group. And it’s evidence that scientific persistence sometimes equals scientific advancement. Credit: Photo by Christopher Gannon/Iowa State University.

Research

Research Laboratories

Can aspirin help prevent colorectal cancer progression?

Drug Discovery World

APRIL 29, 2024

To investigate the effects of aspirin (a nonsteroidal anti-inflammatory drug) on colorectal cancer, investigators in Italy obtained tissue samples from 238 patients who underwent surgery for colorectal cancer in 2015–2019, 12% of whom were aspirin users.

Treatment

Treatment Research Drugs

Remote learning during pandemic aids medical students with disabilities

SCIENMAG: Medicine & Health

AUGUST 18, 2023

The proportion of students reporting attention deficit hyperactivity disorder or chronic health and/or psychological disabilities has increased between 2015 and 2021. Medical students who reported a disability to their school increased by more than 25% during the COVID-19 pandemic, a study shows.

Moderna sues Pfizer/BioNTech over Covid patent

Drug Discovery World

AUGUST 31, 2022

Moderna first started developing this chemical modification in 2010 and validated it in human trials in 2015. They are related to the earlier cases of Moderna’s patented technologies which were clinically tested in 2015 and 2016. The company updated its stance in March 2022 when supply was less of a barrier in parts of the world. .

Vaccine

Vaccine RNA Licensing Licensing

Mothers need more “exclusive breastfeeding” support

SCIENMAG: Medicine & Health

DECEMBER 8, 2023

According to the World Health Organization (WHO), between 2015 and 2021, 48% of mothers exclusively breastfed, meaning that their babies were not given any other food or liquids. Exclusive breastfeeding for the first six months of life is proven to protect both mother and child health.

Alpha Missense

Broad Institute

MARCH 7, 2024

Alpha Missense By lcopelan@broadinstitute.org March 7, 2024 Jun Cheng MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring (..)

Significant “post-COVID” resurgence in invasive meningococcal disease

SCIENMAG: Medicine & Health

NOVEMBER 17, 2023

A team of scientists from the Institut Pasteur has used the database of the National Reference Center for Meningococci to trace the evolution of invasive meningococcal disease cases in France between 2015 and 2022, revealing an unprecedented resurgence in the disease after the easing of control measures imposed during the COVID-19 epidemic.

Disease

Postdoc flash talks

Broad Institute

FEBRUARY 15, 2024

Postdoc flash talks By lcopelan@broadinstitute.org February 15, 2024 MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring (..)

TBD

Broad Institute

FEBRUARY 12, 2024

TBD By lcopelan@broadinstitute.org February 12, 2024 Julia Salzman MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

TBD

Broad Institute

FEBRUARY 12, 2024

TBD By lcopelan@broadinstitute.org February 12, 2024 Tavor Baharav MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

Alpha Missense

Broad Institute

JANUARY 29, 2024

Alpha Missense By lcopelan@broadinstitute.org January 29, 2024 Žiga Avsec Google DeepMind MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 (..)

TBD

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Jose Alquicira-Hernandez MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Protein Structure Prediction (TBD)

Broad Institute

JANUARY 29, 2024

Protein Structure Prediction (TBD) By lcopelan@broadinstitute.org January 29, 2024 Sergey Ovchinnikov MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

TBD

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Joshua Meier MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

Drug shows disease-modifying effect in IgA nephropathy

Drug Discovery World

JANUARY 31, 2024

PLOS ONE 2015). “We Importantly, participants had consistent and stable eGFR with 0mL/min/1.73m2 change from baseline at 72 weeks. Of note, it has been shown that eGFR declines by approximately 1mL/min/1.73m2 per year in the general population (Baba M, et al.

Disease

Disease Clinical Trials Drugs Trials

Valid hypothesis testing after clustering

Broad Institute

JANUARY 29, 2024

Valid hypothesis testing after clustering By lcopelan@broadinstitute.org January 29, 2024 Yiqun Chen MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

Tensor factorization (TBD)

Broad Institute

JANUARY 29, 2024

Tensor factorization (TBD) By lcopelan@broadinstitute.org January 29, 2024 Neriman Tokcan UMass Boston MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall (..)

Valid hypothesis testing after clustering

Broad Institute

JANUARY 29, 2024

Valid hypothesis testing after clustering By lcopelan@broadinstitute.org January 29, 2024 Lucy Gao University of British Columbia, Department of Statistics MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 (..)

TBD

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Aparna Nathan Raychaudhuri Lab, Division of Genetics/Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital; Department of Biomedical Informatics, Harvard Medical School MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall (..)

Medical Schools

Medical Schools Hospitals

Protein Design with Deep Learning: Progress, Challenges, and Next Steps

Broad Institute

MAY 6, 2024

MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

The Market for Image and Performance Enhancing Drugs (IPEDs)

Common Sense for Drug Policy Blog

JUNE 6, 2024

2015 ), with raw powders imported from ‘producer’ countries like China, Egypt, Greece, Thailand, Turkey, and India (Antonopoulos and Hall 2016 ; Brennan et al. 2015 : 241) suggest that some suppliers are subject to a process of normalisation due to their IPED-using peers, and thus do not view themselves as ‘real dealers’.

Marketing

Marketing Drugs Production Pharmaceuticals

On fitness models and the modeling of pandemic evolution

Broad Institute

JANUARY 5, 2024

MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

Multimodal protein language models for deciphering protein function

Broad Institute

MAY 23, 2024

MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

Medical Schools

Medical Schools Research Drugs

CAR T therapy successfully treats solid tumours in China

Drug Discovery World

OCTOBER 17, 2023

In May 2015, the Department of Interventional Oncology of Renji Hospital in Shanghai collaborated with CARsgen Therapeutics to initiate the first clinical study with CAR T cell therapy targeting the GPC3 (Glypican-3) protein in advanced hepatocellular carcinoma. Even with surgical resection, the median overall survival is only 17.8

Therapies

Therapies Hospitals Virus Treatment

Rate of Cancer in Teens, Young Adults Increased From 1973 to 2015

Happy New Year … and a Look Back at a Memorable 2015

Trending Sources

Climate scientists express their views on possible future climate scenarios in a new study

Community Day

German Patient is 7th Person Probably Cured of HIV

Archive

Nalmefene vs Naloxone

'Better than graphene' material development may improve implantable technology

Lightning Talks

TBD

TBD

Microbiome

Melting of Alaskan glaciers accelerating faster than previously thought

Molecular dynamics

Novartis, Pfizer, Otsuka and Novo breach the ABPI Code

Tensor factorization + single-cell rna-seq

Single-cell genomics + LLM or OT

mPTP Inhibitors block mitochondrial dysfunction in ALS

TBD

Need To Conduct a Multi-Variable Study? REPROCELL Can Help with That!

Researchers advance ‘placenta-on-a-chip’ with sensing, imaging technology

Can aspirin help prevent colorectal cancer progression?

Remote learning during pandemic aids medical students with disabilities

Moderna sues Pfizer/BioNTech over Covid patent

Mothers need more “exclusive breastfeeding” support

Alpha Missense

Significant “post-COVID” resurgence in invasive meningococcal disease

Postdoc flash talks

TBD

TBD

Alpha Missense

TBD

Protein Structure Prediction (TBD)

TBD

Drug shows disease-modifying effect in IgA nephropathy

Valid hypothesis testing after clustering

Tensor factorization (TBD)

Valid hypothesis testing after clustering

TBD

Protein Design with Deep Learning: Progress, Challenges, and Next Steps

The Market for Image and Performance Enhancing Drugs (IPEDs)

On fitness models and the modeling of pandemic evolution

Multimodal protein language models for deciphering protein function

CAR T therapy successfully treats solid tumours in China

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