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CAR-NK cells: promising for cancer therapy

Drug Target Review

About the authors Aleta Pupovac Publications Officer, Cartherics Aleta is a cell biologist and immunologist who is passionate about translational science. In 2019, she joined Cartherics focusing on the science underpinning induced pluripotential stem cell differentiation to natural killer cells, and how to manufacture them.

Therapies 118
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Documenting the mammalian brain using machine learning

Drug Target Review

Achieving a mouse brain map has been made possible by advances in computing and data processing, as well as previous work by Lichtman and other researchers like Professor Florian Engert in molecular and cell biology, studying the brains of fruit flies and zebrafish. 2015 February 5 [2023 October 17]; 9(19)1-3. What it is for?

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How nucleolar stress accelerates aging in mice

Drug Target Review

Initial works from the lab concentrated on exploring the role of replicative stress in cancer and ageing, for which the group combined cell biology, mouse models and drug development projects. In 2005, he joined CNIO to lead the Genomic Instability Group where he has been ever since.

RNA 64
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Discovering an Antimalarial Drug in Mao’s China

Codon

The existing literature written in English on this story tends to attribute Tu Youyou’s achievements to a solo discovery, an understandable consequence of Tu receiving the Nobel Prize in Physiology or Medicine in 2015. Miller and Su published an article on Tu’s story in Cell in 2011. Nobody had an answer.

Drugs 129
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Reinventing the small molecule toolbox: from proteins to RNA

Dark Matter Blog

Prior to 2015, I had a casual relationship, at best, with targeting RNA. Targeting RNA is a Whole New World Then in 2015, I became smitten and eloped with RNA, setting out to build a company devoted to bringing to bear industrial drug discovery concepts and methods on a new problem of drugging RNA with small molecules.

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Precision Medicine in the Genomic Era

DrugBank

whitehouse.gov [link] (2015). Nature 526 , 68–74 (2015). Network expansion of genetic associations defines a pleiotropy map of human cell biology. Precision Medicine from a Public Health Perspective. Public Health 39 , 153–168 (2018).  Obama White House Archive.  Jaccard, E., Waeber, G. &

Disease 88
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First Patient Dosed in Monalizumab Phase 3 Clinical Trial Triggers $50M Payment From AstraZeneca

The Pharma Data

About the Innate-AstraZeneca monalizumab agreement : On April 24, 2015, the Company signed a codevelopment and commercialization agreement with AstraZeneca to accelerate and broaden the development of monalizumab. Additional details on the INTERLINK-1 clinical trial can be found here.