Drug Discovery World

AUGUST 5, 2022

Three key members of the team – Dr Raquel Sanches-Kuiper, Vice President of Technology, Dr Matthew Hayes, Chief Technology Officer and John Edgell, Head of Cloud Engineering – explain how the company is doing this and what it means for the advancement of DNA synthesis in the lab. The next goal is to optimise the technology. “At

DNA 130

DNA Engineering Cell Biology Doctors 130

Drug Target Review

APRIL 9, 2024

For his postdoctoral stay he joined the group of André Nussenzweig, where he started to work on DNA repair, particularly focusing on the role of histone H2AX. Since 2015 Oscar is also the Vice Director of CNIO as well as Director of its Molecular Oncology Programme, and professor at the Karolinska Institute in Sweden.

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RNA Cell Biology Clinical Development DNA 64

Codon

JUNE 13, 2024

And what they found, remarkably, is the world’s largest genome ; each fern cell contains 160.45 billion bases of DNA which, if unfurled, would extend for more than 100 meters—taller than the Statue of Liberty. billion bases of DNA, the human genome measures just 2 meters in length when stretched end-to-end.

DNA 60

DNA Molecular Biology Virus International 60

Dark Matter Blog

APRIL 4, 2023

Prior to 2015, I had a casual relationship, at best, with targeting RNA. Targeting RNA is a Whole New World Then in 2015, I became smitten and eloped with RNA, setting out to build a company devoted to bringing to bear industrial drug discovery concepts and methods on a new problem of drugging RNA with small molecules.

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Small Molecule RNA Fragment Screening DNA 52

DrugBank

JUNE 27, 2023

In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g., whitehouse.gov [link] (2015). Nature 526 , 68–74 (2015). Network expansion of genetic associations defines a pleiotropy map of human cell biology.  Jaccard, E.,

Disease 87

Disease Treatment Drugs International 87

Codon

SEPTEMBER 22, 2024

A meiotic cell nucleus beneath the microscope. The first reliable protocols to differentiate human iPSCs into PGC-like cells in vitro were published in 2015. During this process, the cells’ genomes ditch their methyl groups, an important epigenetic mark. The most important step seems to be erasing DNA methylation.

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DNA Laboratories Regulations Engineering 97

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

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DNA Cell Biology Molecular Biology Engineering 91