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How nucleolar stress accelerates aging in mice

Drug Target Review

Initial works from the lab concentrated on exploring the role of replicative stress in cancer and ageing, for which the group combined cell biology, mouse models and drug development projects. Among other discoveries, the group developed inhibitors of the ATR kinase and showed their potential for cancer therapy.

RNA 64
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Discovering an Antimalarial Drug in Mao’s China

Codon

The existing literature written in English on this story tends to attribute Tu Youyou’s achievements to a solo discovery, an understandable consequence of Tu receiving the Nobel Prize in Physiology or Medicine in 2015. Department of Defense administered mefloquine, the synthetic drug developed at Walter Reed in the U.S.,

Drugs 129