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Documenting the mammalian brain using machine learning

Drug Target Review

There is this level of understanding about brains that presently doesn’t exist. 2015 February 5 [2023 October 17]; 9(19)1-3. Lichtman stated: “Connectomics is the only pathway…If we get to a point where doing a whole mouse brain becomes routine, you could think about doing it in, say, animal models of autism. What it is for?

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CAR-NK cells: promising for cancer therapy

Drug Target Review

About the authors Aleta Pupovac Publications Officer, Cartherics Aleta is a cell biologist and immunologist who is passionate about translational science. He was the founding CEO of the Australian Stem Cell Centre. Alan founded the Monash Immunology and Stem Cell Laboratories at Monash University (2004-7).

Therapies 118
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How nucleolar stress accelerates aging in mice

Drug Target Review

Our approach to investigate the toxicity driven by nucleolar stress was to induce it with certain arginine-rich peptides, present in patients of ALS, which were known to accumulate at nucleoli and cause this type of stress. However, our study was first to show that inducing nucleolar stress in an adult mammal accelerates aging.

RNA 64
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Discovering an Antimalarial Drug in Mao’s China

Codon

The existing literature written in English on this story tends to attribute Tu Youyou’s achievements to a solo discovery, an understandable consequence of Tu receiving the Nobel Prize in Physiology or Medicine in 2015. Miller and Su published an article on Tu’s story in Cell in 2011. WRAIR had discovered A.

Drugs 129
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Precision Medicine in the Genomic Era

DrugBank

” 4 The term originally rose to prominence after the completion of the Human Genome Project 5 as a call to action in the face of wide disparities between treatment outcomes within the same clinical presentation; however, the exact meaning has changed as technology continues to advance. whitehouse.gov [link] (2015). Waeber, G. &

Disease 87
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First Patient Dosed in Monalizumab Phase 3 Clinical Trial Triggers $50M Payment From AstraZeneca

The Pharma Data

Presented at the ESMO 2019 Congress, the combination of monalizumab and cetuximab demonstrated a manageable safety profile and a response rate of 27.5% (36% and 17% in IO-naïve, n=22, and IO-pretreated patients, n=18, respectively). Additional details on the INTERLINK-1 clinical trial can be found here.

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A Defense of Peer Review

Codon

Still, shortly after I read Mastroianni’s article, Ben Recht asked on Twitter if there were any articles presenting “a positive case for peer review.” Up to 10 papers were randomly selected and plotted for each year from 1881 to 2015. Each dot corresponds to one research paper.

Science 93