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14 As an unbiased method for genetic variant detection, GWAS holds the promise of identifying new genes and gene regulation mechanisms underlying a variety of conditions, including complex diseases. whitehouse.gov [link] (2015). Nature 526 , 68–74 (2015). Precision Medicine from a Public Health Perspective. Waeber, G. &
A meiotic cell nucleus beneath the microscope. The first reliable protocols to differentiate human iPSCs into PGC-like cells in vitro were published in 2015. Reaching the oogonia stage marked an impressive achievement in germ cellbiology, because previous methods only went up to the PGC stage.
Nature Reviews Molecular CellBiology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular CellBiology (2014). . & Weiss R.
Post-translational modification of proteins, which includes the alteration of certain amino acid side chains by the introduction of different chemical groups, takes place in eukaryotic and prokaryotic cells. For example, it may result in changes to cell metabolism or lead to alterations in crucial signaling events. Proteomics.
Learnings regarding immune geography and cell:cell contact are increasingly important as we consider how best to advance cell therapies for diverse hematologic malignancies and solid tumors ( www.aletabio.com ). The immune system is tightly regulated and unkind to inappropriate signals. Fc-hacking immune responses.
Nature Reviews Molecular CellBiology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular CellBiology (2014). . & Weiss R.
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