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CAR-NK cells: promising for cancer therapy

Drug Target Review

They recognise ‘cell stress molecules’ on the surface of infected, old, injured and cancerous cells without the need for complex pre-stimulation signals of the adaptive immune system (eg, T cells). NK cells can be readily extracted from umbilical cord blood or peripheral blood of adult donors.

Therapies 118
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How nucleolar stress accelerates aging in mice

Drug Target Review

Initial works from the lab concentrated on exploring the role of replicative stress in cancer and ageing, for which the group combined cell biology, mouse models and drug development projects. Among other discoveries, the group developed inhibitors of the ATR kinase and showed their potential for cancer therapy.

RNA 64
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Discovering an Antimalarial Drug in Mao’s China

Codon

The existing literature written in English on this story tends to attribute Tu Youyou’s achievements to a solo discovery, an understandable consequence of Tu receiving the Nobel Prize in Physiology or Medicine in 2015. Miller and Su published an article on Tu’s story in Cell in 2011. Nobody had an answer.

Drugs 129
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Precision Medicine in the Genomic Era

DrugBank

Their use, as well as their integration into other types of data, has enabled the development of more precise therapies. whitehouse.gov [link] (2015). Nature 526 , 68–74 (2015). Network expansion of genetic associations defines a pleiotropy map of human cell biology.  Obama White House Archive.

Disease 88
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First Patient Dosed in Monalizumab Phase 3 Clinical Trial Triggers $50M Payment From AstraZeneca

The Pharma Data

INTERLINK-1 represents first Phase 3 study examining IO approach in R/M SCCHN patients who have been treatedwith a platinum-based therapy and PD-(L)1 inhibitor. Overall, the combination therapy data to date supports the expedited development of monalizumab and cetuximab in this indication. MARSEILLE, France, Oct.

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Making Eggs Without Ovaries

Codon

A meiotic cell nucleus beneath the microscope. The first reliable protocols to differentiate human iPSCs into PGC-like cells in vitro were published in 2015. Reaching the oogonia stage marked an impressive achievement in germ cell biology, because previous methods only went up to the PGC stage.

DNA 96
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Teaching immune cells how to kill

SugarCone Biotech

Learnings regarding immune geography and cell:cell contact are increasingly important as we consider how best to advance cell therapies for diverse hematologic malignancies and solid tumors ( www.aletabio.com ). Aren’t we just waking up exhausted T cells, or moving T cells from the tumor margin into the tumor bed?