Broad Institute

MAY 14, 2024

By 1984, he and Brookhaven colleague John Dunn successfully identified and cloned the protein within T7 that was responsible for rapidly copying T7 DNA into many corresponding strands of RNA — a critical step in the bacteriophage’s ability to infect E. coli genome and let the E. coli had no built-in way to shut it off.

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RNA Production Molecular Biology Laboratories 84

Codon

DECEMBER 10, 2023

Einstein predicted the existence of gravitational waves in 1916, but LIGO did not detect them until 2015. This last variable could be just about anything; there are proteins that bind to other proteins (like antibodies), cut other proteins (proteases), or bind DNA (transcription factors). Synthesizing that much DNA is cost-prohibitive.

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Protein Expression Laboratories DNA Engineering 103

Drug Target Review

MAY 24, 2024

2 AlphaFold 3 has been built to model DNA, RNA and smaller molecules (ligands). Google DeepMind’s new AI can model DNA, RNA, and ‘all life’s molecules’. There are several technologies and specific tools being rolled out in this area. The latest exciting advancement is AlphaFold 3, which was just released. Alphafold 3.0:

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RNA DNA Bioinformatics Science 59

The Pharma Data

NOVEMBER 22, 2020

The two companies have been in a strategic research collaboration agreement since 2015, focused on using CRISPR Cas-9 to discover new potential treatments. Cas-9 represents the Cas9 protein, an enzyme that cuts foreign DNA. Once the DNA has been cut, the cell’s natural repair mechanisms kick in. ” Source link.

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DNA Medical Schools Treatment Science 52

PLOS: DNA Science

JUNE 8, 2023

That was so in 1977, when “intervening DNA sequences” – aka “introns” – were discovered to interrupt protein-encoding genes. Because the edits are in RNA, and not DNA, they are fleeting. The post How (and Why) the Octopus Edits its RNA appeared first on DNA Science.

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RNA DNA Science Laboratories 52

Codon

DECEMBER 10, 2023

Einstein predicted the existence of gravitational waves in 1916, but LIGO did not detect them until 2015. This last variable could be just about anything; there are proteins that bind to other proteins (like antibodies), cut other proteins (proteases), or bind DNA (transcription factors). Synthesizing that much DNA is cost-prohibitive.

Protein Expression 81

Protein Expression Laboratories DNA Engineering 81

Drug Target Review

AUGUST 9, 2023

The specific proteins found in these aggregates can vary, but approximately 95 percent of ALS patients and 50 percent of FTD patients develop aggregates containing the TDP-43 protein (short for tar DNA binding protein 43). 14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts.

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RNA Regulations Disease DNA 98

Drug Target Review

OCTOBER 4, 2023

2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads. DNA damaging agent-based antibody-drug conjugates for cancer therapy. While highly effective against proliferating tumour cells, ADCs with antimitotic payloads typically struggled against slower-growing cancer types.

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Small Molecule Drugs Immune Response Targeted Protein Degradation 126

Broad Institute

FEBRUARY 29, 2024

Related news Antibiotic-resistant microbes date back to 450 MYA, well before the age of dinosaurs One day in 2015, Joseph Manson placed in his refrigerator the colon of a wild turkey he’d just hunted near his small farm in South Carolina.

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Hospitals Medical Schools International Research 116

Drug Target Review

APRIL 9, 2024

For his postdoctoral stay he joined the group of André Nussenzweig, where he started to work on DNA repair, particularly focusing on the role of histone H2AX. Since 2015 Oscar is also the Vice Director of CNIO as well as Director of its Molecular Oncology Programme, and professor at the Karolinska Institute in Sweden.

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RNA Cell Biology Clinical Development DNA 64

Broad Institute

JULY 10, 2023

At the Broad, Martin is also helping lead data analysis in two large international studies that are sequencing the DNA of people from Africa and Latin America to learn about the genetics of severe mental illness. “I think our work is helping move a lot of researchers to study underrepresented populations, and I’m really proud of that.”

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Disease Bioinformatics Medical Schools Research 98

Codon

MAY 15, 2023

Ratcliff, figured this out back in 2015. 3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. Known as a "search-and-replace" gene-editing tool, prime editors can delete or replace DNA up to 10,000 bases in length, or substitute one base for another. From Davis J.R.

DNA 52

DNA Bioinformatics Engineering Virus 52

Codon

MAY 15, 2023

Ratcliff, figured this out back in 2015. 3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. Known as a "search-and-replace" gene-editing tool, prime editors can delete or replace DNA up to 10,000 bases in length, or substitute one base for another. From Davis J.R.

DNA 52

DNA Bioinformatics Engineering Virus 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

PLOS: DNA Science

SEPTEMBER 21, 2023

What steps should researchers take when attempting to acquire DNA samples from modern descendants? I was lucky at the ASHG meeting in October 2015. I didn’t even recall providing a DNA sample to Ancestry.com years ago at a conference, when, in 2018, a woman who thought she was my cousin contacted me.

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DNA Science Medical Schools Government 52

Dark Matter Blog

APRIL 4, 2023

Prior to 2015, I had a casual relationship, at best, with targeting RNA. Targeting RNA is a Whole New World Then in 2015, I became smitten and eloped with RNA, setting out to build a company devoted to bringing to bear industrial drug discovery concepts and methods on a new problem of drugging RNA with small molecules.

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The Pharma Data

DECEMBER 17, 2020

She assists both patients and physicians in completing this revolutionary gene test that determines if a patient is on the right drug, at the right dose, for their specific DNA. After relocating to Montgomery, Alabama, she retained this title and its responsibilities at Jackson Hospital from 2008 to 2015.

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Codon

MARCH 19, 2024

Most cells (excluding T-cells and B cells after V(D)J recombination) in our body contain the same DNA but appear and behave in distinct ways: A neuron looks and acts very differently from a hepatocyte. While DNA is relatively stable , the epigenome is not; it has to orchestrate changes in cell state, cell type, and more.

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DNA Small Molecule Regulations Laboratories 57

PLOS: DNA Science

MARCH 30, 2023

Comparing genome sequences is important because they provide a 4-letter language in the bases A, C, G, and T (for DNA) or A, C, G, and U (for RNA). The agency started tracking it in 2013, and the spread accelerated in 2015. The post The New Fungus Among Us, Candida auris appeared first on DNA Science.

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DNA Hospitals Laboratories Virus 52

Molecule Blog

AUGUST 13, 2021

His work focused on the cross-talk between DNA repair and mitochondrial function in aging and has been honored by a number of competitive awards. He now runs one of the largest research programmes in Europe focusing on aging.

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FDA Approval DNA Small Molecule FDA 52

The Pharma Data

MAY 18, 2021

MMR is a molecular mechanism that functions to correct certain errors that can spontaneously occur during DNA replication. This companion diagnostic (CDx) provides clinicians with a standardised testing option that uses a comprehensive panel of DNA mismatch repair (MMR) biomarkers tested by immunohistochemistry (IHC). 2015:26(1):40-45.

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Codon

APRIL 23, 2024

While astronauts are easily protected from UV by glass or a thin sheet of metal, microbes placed outside on Mars would be killed in mere minutes as the ultraviolet radiation shreds through DNA and destabilizes proteins that carry out important cellular processes. 2 Our microbial engineering efforts include plans for biocontainment.

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Engineering DNA Hospitals International 98

Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

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DNA Engineering Therapies RNA 52

DrugBank

JUNE 27, 2023

In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g., whitehouse.gov [link] (2015). Nature 526 , 68–74 (2015). Coding mutations have a more direct effect through direct alteration of a gene product.  Obama White House Archive.

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DrugBaron

NOVEMBER 22, 2022

In 2015, Methuselah Health was founded to investigate the role of proteome instability during ageing, and the extent to which the instability of specific proteins might underlie development of age-related diseases – a concept that arose from the ground-breaking work of Professor Miro Radman (which DrugBaron highlighted previously).

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Bioinformatics Regulations Molecular Biology Engineering 100

NIH Director's Blog: Drug Development

MAY 15, 2018

It relies on transposons—snippets of DNA sometimes referred to as “jumping genes” for inserting themselves randomly into the genome—to disrupt thousands of genes in the P. falciparum genome. 1985 Sep;145(2):356-361. [5] 5] Malaria’s impact worldwide. Centers for Disease Control and Prevention. [6] World Health Organization.

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Drug Development Drugs Disease Treatment 52

Advarra

AUGUST 10, 2023

However, recent advancements in the clinical use of recombinant DNA (rDNA) technology creates opportunities for changing this calculation and addressing a great, unmet medical need. “I The pace has since increased: 2022 and 2023 each saw three approvals issued.

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Drug Development Disease Therapies Engineering 52

The Pharma Data

OCTOBER 14, 2020

Lanifibranor is believed to be the first drug candidate to be granted this status for the treatment of NASH since January 2015. Food and Drug Administration granted Breakthrough Therapy designation to France-based Inventiva’s experimental NASH treatment lanifibranor.

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Clinical Trials Trials Pharmaceuticals Therapies 52

The Pharma Data

SEPTEMBER 2, 2021

Changing treatment paradigms with industry-leading PARP inhibitors and next-wave DNA damage response therapies. AstraZeneca obtained full oncology rights to monalizumab from Innate Pharma in October 2018 through a co-development and commercialisation agreement initiated in 2015. DNA damage response. Abstract #LBA49.

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Trials Clinical Trials Therapies Disease 52

The Pharma Data

JUNE 30, 2021

Mismatch repair deficiency (dMMR) occurs when the proteins that repair mismatch errors in DNA replication are missing or non-functional, leading to microsatellite instability-high (MSI-H) tumors. Approximately 5% of metastatic CRC patients have dMMR or MSI-H tumors.

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Treatment Trials FDA Approval Disease 52

Agency IQ

AUGUST 11, 2023

The International Agency for Research on Cancer (IARC), part of the World Health Organization (WHO), deemed glyphosate to be “ probably carcinogenic to humans ” (Carcinogen 2A) in 2015. and EU, however, have diverged from this conclusion. A close examination of the full risk assessment indicates exactly what these data gaps are.

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Regulations Marketing DNA Production 40

NIH Director's Blog: Drug Development

JANUARY 5, 2016

But before diving into our first “new science” post of 2016, let’s take a quick look back at 2015 and some of its remarkable accomplishments. Four of 2015’s Top 10 featured developments directly benefited from NIH support—including Science’s “Breakthrough of the Year,” the CRISPR/Cas9 gene-editing technique. Protein Cell.

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Vaccine Science Engineering Disease 52

Codon

SEPTEMBER 22, 2024

The first reliable protocols to differentiate human iPSCs into PGC-like cells in vitro were published in 2015. Erasing methyl groups on DNA is necessary for normal egg and sperm development. The most important step seems to be erasing DNA methylation. A meiotic cell nucleus beneath the microscope. Image provided by the author.

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DNA Laboratories Regulations Therapies 112

PLOS: DNA Science

APRIL 4, 2024

It debuted in January 2024 , but the company has been around since 2015. The post How Lume Whole Body Deodorant Was Inspired by a Genetic Disease appeared first on DNA Science. As soon as I started researching Lume, my social media and even TV blew up with ads for these products, as if I have suddenly begun to stink.

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Disease Production Testimonials FDA 91

The Premier Consulting Blog

APRIL 25, 2023

ICH Harmonised Guideline M7(R1): Assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals to limit potential carcinogenic risk. Summary basis of approval (SBA) for Aristada (NDA 207533, 10/5/2015), [link] [accessed 23 March 2023]. 8] US Food and Drug Administration (FDA).

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FDA Animal Testing Pharmacokinetics Pharmaceuticals 52

Codon

APRIL 19, 2023

kilograms of CO 2 and 330 liters of water to make one kilogram of bananas, according to a 2015 study from Ecuador. In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening.

DNA 52

DNA RNA Engineering Regulations 52