Drug Discovery World

JULY 31, 2023

Matt Hill , Founder and CEO of Elegen writes about the importance of innovation in DNA synthesis to address critical bottlenecks in biotherapy development. Regardless of the type of disease targeted, at the core of biotherapy development is synthetic biology and the use of synthetic DNA to programme specific behaviours within living cells.

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Drug Target Review

APRIL 9, 2024

For his postdoctoral stay he joined the group of André Nussenzweig, where he started to work on DNA repair, particularly focusing on the role of histone H2AX. Since 2015 Oscar is also the Vice Director of CNIO as well as Director of its Molecular Oncology Programme, and professor at the Karolinska Institute in Sweden.

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Drug Discovery World

FEBRUARY 14, 2024

While a typical chemisty, manufacturing and controls (CMC) timeline from DNA to Investigational New Drug (IND) application in 2015 would have been approximately 24 months, by 2023 the same pathway was expected to take only 10 months.

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Drug Target Review

SEPTEMBER 4, 2023

5 Cytology-based profiling can facilitate antibiotic discovery efforts and, these assays assess cell cycle progression, nuclear and mitochondrial DNA content, mitochondrial DNA replication, nuclear DNA damage, mitochondrial membrane potential, and lysosome structure and function. and Wolfgang, H. Gabriela, S. Andreas, B.,

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Drug Discovery World

DECEMBER 14, 2023

Then Nexus was acquired by Brooks Automation and we were able to acquire the Aurora business in October 2015. But it comes with surface charge that will absorb proteins, DNA, and other things, unless you do something to treat that surface.

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Broad Institute

FEBRUARY 29, 2024

Related news Antibiotic-resistant microbes date back to 450 MYA, well before the age of dinosaurs One day in 2015, Joseph Manson placed in his refrigerator the colon of a wild turkey he’d just hunted near his small farm in South Carolina.

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The Pharma Data

MAY 18, 2021

MMR is a molecular mechanism that functions to correct certain errors that can spontaneously occur during DNA replication. This companion diagnostic (CDx) provides clinicians with a standardised testing option that uses a comprehensive panel of DNA mismatch repair (MMR) biomarkers tested by immunohistochemistry (IHC). 2015:26(1):40-45.

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Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

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The Pharma Data

DECEMBER 17, 2020

She assists both patients and physicians in completing this revolutionary gene test that determines if a patient is on the right drug, at the right dose, for their specific DNA. After relocating to Montgomery, Alabama, she retained this title and its responsibilities at Jackson Hospital from 2008 to 2015.

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Codon

APRIL 23, 2024

While astronauts are easily protected from UV by glass or a thin sheet of metal, microbes placed outside on Mars would be killed in mere minutes as the ultraviolet radiation shreds through DNA and destabilizes proteins that carry out important cellular processes. 2 Our microbial engineering efforts include plans for biocontainment.

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Drug Discovery World

JULY 15, 2022

The remaining 8% of the genome was often referred to as the dark matter of the genome or sometimes even ‘Junk DNA’ 2. The sequencing technology relied on could only yield sequences of relatively short DNA fragments, so the assembly of sequences from highly repetitive regions was a huge challenge.

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NIH Director's Blog: Drug Development

MAY 15, 2018

It relies on transposons—snippets of DNA sometimes referred to as “jumping genes” for inserting themselves randomly into the genome—to disrupt thousands of genes in the P. falciparum genome. 1985 Sep;145(2):356-361. [5] 5] Malaria’s impact worldwide. Centers for Disease Control and Prevention. [6] World Health Organization.

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Agency IQ

AUGUST 11, 2023

The International Agency for Research on Cancer (IARC), part of the World Health Organization (WHO), deemed glyphosate to be “ probably carcinogenic to humans ” (Carcinogen 2A) in 2015. and EU, however, have diverged from this conclusion. A close examination of the full risk assessment indicates exactly what these data gaps are.

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Codon

JUNE 13, 2024

billion bases of DNA which, if unfurled, would extend for more than 100 meters—taller than the Statue of Liberty. billion bases of DNA, the human genome measures just 2 meters in length when stretched end-to-end. Credit: Oriane Hidalgo Per the book Cell Biology by the Numbers , each base pair of DNA occupies 1 nm 3 of space.

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Broad Institute

MAY 14, 2024

By 1984, he and Brookhaven colleague John Dunn successfully identified and cloned the protein within T7 that was responsible for rapidly copying T7 DNA into many corresponding strands of RNA — a critical step in the bacteriophage’s ability to infect E. coli genome and let the E. coli had no built-in way to shut it off.

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PLOS: DNA Science

JUNE 8, 2023

That was so in 1977, when “intervening DNA sequences” – aka “introns” – were discovered to interrupt protein-encoding genes. Because the edits are in RNA, and not DNA, they are fleeting. The post How (and Why) the Octopus Edits its RNA appeared first on DNA Science.

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Codon

DECEMBER 10, 2023

Einstein predicted the existence of gravitational waves in 1916, but LIGO did not detect them until 2015. This last variable could be just about anything; there are proteins that bind to other proteins (like antibodies), cut other proteins (proteases), or bind DNA (transcription factors). Synthesizing that much DNA is cost-prohibitive.

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PLOS: DNA Science

SEPTEMBER 21, 2023

What steps should researchers take when attempting to acquire DNA samples from modern descendants? I was lucky at the ASHG meeting in October 2015. I didn’t even recall providing a DNA sample to Ancestry.com years ago at a conference, when, in 2018, a woman who thought she was my cousin contacted me.

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Codon

DECEMBER 10, 2023

Einstein predicted the existence of gravitational waves in 1916, but LIGO did not detect them until 2015. This last variable could be just about anything; there are proteins that bind to other proteins (like antibodies), cut other proteins (proteases), or bind DNA (transcription factors). Synthesizing that much DNA is cost-prohibitive.

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Drug Discovery World

MAY 11, 2023

In addition, their cumbersome developmental process limits their use for fast-tracked new modalities, such as DNA-based vaccines. 2015): 1727-1737. She joined SCIEX in 2015, and had various roles focusing on biopharma, protein and oligonucleotide characterisation with accurate mass spectrometry. Collins, Ben C., 2017): 1-12.

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Drug Discovery World

MARCH 6, 2024

They also involve multiple mutations in non-coding regions of DNA – the ‘dark genome’ which makes up around 98% of our DNA. Their socioeconomic costs are measured in hundreds of billions of dollars per year.

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Clinical Trials Pharmaceutical Companies Disease Trials 162

Dark Matter Blog

APRIL 4, 2023

Prior to 2015, I had a casual relationship, at best, with targeting RNA. Targeting RNA is a Whole New World Then in 2015, I became smitten and eloped with RNA, setting out to build a company devoted to bringing to bear industrial drug discovery concepts and methods on a new problem of drugging RNA with small molecules.

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Codon

MAY 15, 2023

Ratcliff, figured this out back in 2015. 3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. Known as a "search-and-replace" gene-editing tool, prime editors can delete or replace DNA up to 10,000 bases in length, or substitute one base for another. From Davis J.R.

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Codon

MAY 15, 2023

Ratcliff, figured this out back in 2015. 3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. Known as a "search-and-replace" gene-editing tool, prime editors can delete or replace DNA up to 10,000 bases in length, or substitute one base for another. From Davis J.R.

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DNA Bioinformatics Engineering Virus 52

Codon

MARCH 19, 2024

Most cells (excluding T-cells and B cells after V(D)J recombination) in our body contain the same DNA but appear and behave in distinct ways: A neuron looks and acts very differently from a hepatocyte. While DNA is relatively stable , the epigenome is not; it has to orchestrate changes in cell state, cell type, and more.

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Drug Target Review

AUGUST 9, 2023

The specific proteins found in these aggregates can vary, but approximately 95 percent of ALS patients and 50 percent of FTD patients develop aggregates containing the TDP-43 protein (short for tar DNA binding protein 43). 14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts.

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Broad Institute

JULY 10, 2023

At the Broad, Martin is also helping lead data analysis in two large international studies that are sequencing the DNA of people from Africa and Latin America to learn about the genetics of severe mental illness. “I think our work is helping move a lot of researchers to study underrepresented populations, and I’m really proud of that.”

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Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

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Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

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DNA RNA Engineering Vaccine 52

Molecule Blog

AUGUST 13, 2021

His work focused on the cross-talk between DNA repair and mitochondrial function in aging and has been honored by a number of competitive awards. He now runs one of the largest research programmes in Europe focusing on aging.

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PLOS: DNA Science

MARCH 30, 2023

Comparing genome sequences is important because they provide a 4-letter language in the bases A, C, G, and T (for DNA) or A, C, G, and U (for RNA). The agency started tracking it in 2013, and the spread accelerated in 2015. The post The New Fungus Among Us, Candida auris appeared first on DNA Science.

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Drug Target Review

OCTOBER 4, 2023

2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads. DNA damaging agent-based antibody-drug conjugates for cancer therapy. While highly effective against proliferating tumour cells, ADCs with antimitotic payloads typically struggled against slower-growing cancer types.

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The Pharma Data

NOVEMBER 22, 2020

The two companies have been in a strategic research collaboration agreement since 2015, focused on using CRISPR Cas-9 to discover new potential treatments. Cas-9 represents the Cas9 protein, an enzyme that cuts foreign DNA. Once the DNA has been cut, the cell’s natural repair mechanisms kick in. ” Source link.

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PLOS: DNA Science

APRIL 4, 2024

It debuted in January 2024 , but the company has been around since 2015. The post How Lume Whole Body Deodorant Was Inspired by a Genetic Disease appeared first on DNA Science. As soon as I started researching Lume, my social media and even TV blew up with ads for these products, as if I have suddenly begun to stink.

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Advarra

AUGUST 10, 2023

However, recent advancements in the clinical use of recombinant DNA (rDNA) technology creates opportunities for changing this calculation and addressing a great, unmet medical need. “I The pace has since increased: 2022 and 2023 each saw three approvals issued.

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The Pharma Data

SEPTEMBER 2, 2021

Changing treatment paradigms with industry-leading PARP inhibitors and next-wave DNA damage response therapies. AstraZeneca obtained full oncology rights to monalizumab from Innate Pharma in October 2018 through a co-development and commercialisation agreement initiated in 2015. DNA damage response. Abstract #LBA49.

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